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Protein
Submitted name:

Aspartyl aminopeptidase

Gene

DNPEP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartyl aminopeptidaseImported
Gene namesi
Name:DNPEPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000123992.18
HGNCiHGNC:2981 DNPEP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123992

PTM / Processingi

Proteomic databases

EPDiB9ZVU2
MaxQBiB9ZVU2
PeptideAtlasiB9ZVU2
PRIDEiB9ZVU2

Expressioni

Gene expression databases

BgeeiENSG00000123992 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiB9ZVU2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB9ZVU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M18 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000003164
HOGENOMiHOG000253244

Family and domain databases

Gene3Di2.30.250.10, 1 hit
InterProiView protein in InterPro
IPR001948 Peptidase_M18
IPR023358 Peptidase_M18_dom2
PANTHERiPTHR28570 PTHR28570, 1 hit
PfamiView protein in Pfam
PF02127 Peptidase_M18, 1 hit
PRINTSiPR00932 AMINO1PTASE

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

B9ZVU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGHSPTRGA MQVAMNGKAR KEAVQTAAKE LLKFVNRSPS PFHAVAECRN
60 70 80 90 100
RLLQAGFSEL KETEKWNIKP ESKYFMTRNS STIIAFAVGG QYVPGNGFSL
110 120 130 140 150
IGAHTDSPCL RVKRRSRRSQ VGFQQVGVET YGGGIWSTWF DRDLTLAGRV
160 170 180 190 200
IVKCPTSGRL EQQLVHVERP ILRIPHLAIH LQRNINENFG PNTEMHLCAL
210 220 230 240 250
LAIPPQPTSP HRVPILATAI QEELEKGTPE PGPLNAVDER HHSVLMSLLC
260 270
AHLGLSPKDI VEMELCLADT
Length:270
Mass (Da):29,865
Last modified:November 3, 2009 - v2
Checksum:iDA73760A032334A9
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9ULA0DNPEP_HUMAN
Aspartyl aminopeptidase
DNPEP ASPEP, DAP
475Annotation score:
E7ETB3E7ETB3_HUMAN
Aspartyl aminopeptidase, isoform CR...
DNPEP hCG_15581
493Annotation score:
C9JBE1C9JBE1_HUMAN
Aspartyl aminopeptidase
DNPEP
331Annotation score:
E7EMB6E7EMB6_HUMAN
Aspartyl aminopeptidase
DNPEP
410Annotation score:
C9J1E2C9J1E2_HUMAN
Aspartyl aminopeptidase
DNPEP
137Annotation score:
F8WAN0F8WAN0_HUMAN
Aspartyl aminopeptidase
DNPEP
273Annotation score:
E7EPX3E7EPX3_HUMAN
Aspartyl aminopeptidase
DNPEP
224Annotation score:
C9JRG3C9JRG3_HUMAN
Aspartyl aminopeptidase
DNPEP
117Annotation score:
A0A024R442A0A024R442_HUMAN
Aspartyl aminopeptidase, isoform CR...
DNPEP hCG_15581
471Annotation score:
E5RJ35E5RJ35_HUMAN
Aspartyl aminopeptidase
DNPEP
89Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei270Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC053503 Genomic DNA No translation available.
KF456770 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000322176; ENSP00000317252; ENSG00000123992
UCSCiuc061swx.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC053503 Genomic DNA No translation available.
KF456770 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliB9ZVU2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB9ZVU2
MaxQBiB9ZVU2
PeptideAtlasiB9ZVU2
PRIDEiB9ZVU2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322176; ENSP00000317252; ENSG00000123992
UCSCiuc061swx.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000123992.18
HGNCiHGNC:2981 DNPEP
OpenTargetsiENSG00000123992
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003164
HOGENOMiHOG000253244

Gene expression databases

BgeeiENSG00000123992 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiB9ZVU2 baseline and differential

Family and domain databases

Gene3Di2.30.250.10, 1 hit
InterProiView protein in InterPro
IPR001948 Peptidase_M18
IPR023358 Peptidase_M18_dom2
PANTHERiPTHR28570 PTHR28570, 1 hit
PfamiView protein in Pfam
PF02127 Peptidase_M18, 1 hit
PRINTSiPR00932 AMINO1PTASE
ProtoNetiSearch...

Entry informationi

Entry nameiB9ZVU2_HUMAN
AccessioniPrimary (citable) accession number: B9ZVU2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 14, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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