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Entry version 51 (08 May 2019)
Sequence version 1 (14 Apr 2009)
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Protein

Nonribosomal peptide synthetase 13

Gene

NRPS13

Organism
Neosartorya fumigata (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the condensation of L-tryptophan and L-proline to produce brevianamide F, the first step of verruculogen biosynthesis pathway. Brevianamide F is the precursor of a variety of fungal prenylated alkaloids with biological activity, including fumitremorgins A, B and C and tryprostatin B. Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Alkaloid biosynthesis

This protein is involved in Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in Alkaloid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase
Biological processAlkaloid metabolism, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-18761

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase 13 (EC:6.3.3.-)
Alternative name(s):
Brevianamide F synthase
Fumitremorgin biosynthesis protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS13
Synonyms:ftmA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri746128 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004241091 – 2211Nonribosomal peptide synthetase 13Add BLAST2211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei631O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1714O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B9WZX0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B9WZX0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini594 – 671Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini1677 – 1756Carrier 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 475Adenylation 1By similarityAdd BLAST400
Regioni710 – 975Condensation 1By similarityAdd BLAST266
Regioni1169 – 1563Adenylation 2By similarityAdd BLAST395
Regioni1814 – 2069Condensation 2By similarityAdd BLAST256

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS13 has the following architecture: A-T-C-A-T-C.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217313

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 2 hits
PF00668 Condensation, 2 hits
PF00550 PP-binding, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 2 hits
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9WZX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMALAVGAP SEQRGNLPYN TLKDGPTVDS MKATTDGKNG QGESAFWDTC
60 70 80 90 100
VHTVFREHCQ RAPNSPAVNA WDGSFTYAEL DSLSDAIASV LILSGVGPES
110 120 130 140 150
IIPIYMQKSR WTTVAILGVL KSGGAFTLLD PSHPRSRVEE ISKEIQARFI
160 170 180 190 200
LTSEKLSKQC LEMFSVLVVE HLSRACLPSP GQAGHTRSRP ENAAYIAFTS
210 220 230 240 250
GSTGKPKGIV IEHRSYCSGA RSHLKVFGID STSRVLQFAS YAFDVSIMET
260 270 280 290 300
LSTLMAGGCL CVMSESERSD PNLFVVSYKN LRISHCFMTP SFARTVPWTE
310 320 330 340 350
CCNPPPTLIV GGELMRPSDA RAYKEMGIRC MNAYGPAECS VNVSVQSRVE
360 370 380 390 400
AAVDPRNIGY TTGATAWIIS PENPEELMPT GTVGELLVEG PIVGRGYLND
410 420 430 440 450
PKATRQAFID TPAWLRRHRK GTSYQHRVYR TGDLASLDSI TGALLLHGRK
460 470 480 490 500
DAQVKIRGQR VELPDIEHHL QLTLPNDNAE VIVEKVTFSD DGSEKLIAFV
510 520 530 540 550
LVRPSNTDSV IGNTGDRLFL APQSQIMEQF AISKKHLQTH LPSYMVPDIF
560 570 580 590 600
IPISTLPQTA SGKTDRKALR TRAAALSRRD VQCFLLSPAG GKRPPSTPKE
610 620 630 640 650
ATIRSLYSNV LNLPIDLIGM DDTFLRLGGD SLQAIRLVAA ARAAGLILHA
660 670 680 690 700
KDILSSQSTL AEQSKRAGLI QTIDRTWESS PPFALLHGPT RHAIVDLAQK
710 720 730 740 750
QCRVPSNLIE DIYPCTALQE GMFITSLKHP GMYTGQIIFD IPDRMELPRL
760 770 780 790 800
KAAWLSVVSE NAALRTRIIE THEGLMQAVI VDDFVWEEET DEMLLSSDGE
810 820 830 840 850
ALEITKIGVP LVRFRYRPRH RQLMMTIHHS IWDGWSLRLV HEQLQRAYIG
860 870 880 890 900
RDLLPSTSYR SFIQYTQELP GADEFWASEL AGVNAPIFPT LPSGNYRPRV
910 920 930 940 950
NASHRHVVRN LASTGKEEHT AATYIHLAWS LLVAHYTDAD ETVYGVTVNG
960 970 980 990 1000
RSADVPGIEN IVGPTIATVP TRIRVNEEDT VEMALDHVQD ALARMIPYEQ
1010 1020 1030 1040 1050
AGLQRISRCS RDASEACRFQ NLLIIEAPTD SDVDCEKNEA GNFSIIGGTT
1060 1070 1080 1090 1100
QTGMDYTAFS SYAMMLVFRT SANKSAISFD ITYDAQVIGH DEVERMAHQF
1110 1120 1130 1140 1150
EHVLRHIYTL ATGRIGDISF IGPRDIEQVQ QWNSSMPPAD NRFLQELIFA
1160 1170 1180 1190 1200
QCSRRPQASA IISWDGSWTY RELWAHSSFF ARQLQRYGVT RGTPVAVCLD
1210 1220 1230 1240 1250
RSRWSIAVIL GVLLARGTCV LIDLLAPRQR VRDILQIAGT GILVHSHATA
1260 1270 1280 1290 1300
TLTSGLCPTV INVSFLAAQS DSSQPEFPFT LETWGGTPED LAFIIFTSGS
1310 1320 1330 1340 1350
TGHPKGIEMP HRTLSTSISH HSAGMRVTSS SRVLHFSSYA FDVSIYEIFT
1360 1370 1380 1390 1400
TLAAGGTICV PSEFDRMNNL AGFIQDTQVN WAFLTPSTAR SLNPADVPLL
1410 1420 1430 1440 1450
TTLVLGGEAV THESVEVWAK GRSLINGYGP AEATICGVGN IPEAGWKSGV
1460 1470 1480 1490 1500
VGRIIGGLGW VTVPSDPNRL AAVGAVGELL LEGPFLARGY LNLPEVTKAA
1510 1520 1530 1540 1550
FIDPPSWRTR IPAPSPYSFL YRTGDLVRYQ PDGSIQYVGR KDSRVKLRGQ
1560 1570 1580 1590 1600
LVDLGAVEAS VMRVYPAAGQ VVADVLVSEN TARLIAMVKL GPSVTENHDG
1610 1620 1630 1640 1650
PMFAAPDLVF NEAAASIQAR LRAIVPAYMV PSMFIPLRHI PRTLTGKTDR
1660 1670 1680 1690 1700
RRLRDKILSL SHSDLQRYMM SSSTKTPMSD DNERRLQEIW AEVLQLPCEA
1710 1720 1730 1740 1750
IGREDSFLSL GGESLATMKM VALARRVGFM FAVTDVMNNT SLSTLARSRH
1760 1770 1780 1790 1800
LITEQAILTS SPSLSLPTIE GESLQEILRP LLNAGHIQGG NDIAAIHPVT
1810 1820 1830 1840 1850
AAQAFLVQRY PWSHFQFDLS GAVSPSKLQT ACTALMARFT ILRTVFVEHA
1860 1870 1880 1890 1900
GCLLQLVLRE VPNRVHEITT NEPLDDFCNS VCQQQQDVCV VNSTTLPTLF
1910 1920 1930 1940 1950
TLVSNRQLNR HRLLLRLAHA QYDLTTIPLI VQSLADEYNR TLRSGFSADF
1960 1970 1980 1990 2000
GYYLSHHKRQ NNDDRSHNFW KRYLSGSSMM STNQTADPTT VQERVFHVTG
2010 2020 2030 2040 2050
SCIIIPTSHP PDITIATAVK AAVCLVLAAR TGCTDIVIGQ TVDARCSSAD
2060 2070 2080 2090 2100
STLDQIVGPC TNYIPYRLSV CCSKTALEYL RSAQAQHTTC LRYSSLDLDQ
2110 2120 2130 2140 2150
IVAKCTSWPS STQFGYIVQH QDTGAELALT LGGDTTSLPM TSYGRVFPQG
2160 2170 2180 2190 2200
EVWIGSTPCS TGLRIDVIAL SAVLSQKDAQ TMAEEVGAAL EKLLGCGYRR
2210
LSHLIGNTFA T
Length:2,211
Mass (Da):242,786
Last modified:April 14, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E275CDC515B5618
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB436628 Genomic DNA Translation: BAH23995.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB436628 Genomic DNA Translation: BAH23995.1

3D structure databases

SMRiB9WZX0
ModBaseiSearch...

Proteomic databases

PRIDEiB9WZX0

Phylogenomic databases

HOGENOMiHOG000217313

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18761

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 2 hits
PF00668 Condensation, 2 hits
PF00550 PP-binding, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 2 hits
PS50075 CARRIER, 2 hits
PS00012 PHOSPHOPANTETHEINE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTMA_ASPFM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9WZX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: April 14, 2009
Last modified: May 8, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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