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Entry version 61 (12 Aug 2020)
Sequence version 1 (24 Mar 2009)
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Protein

Trehalase

Gene

NTC1

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotationImportedARBA annotation, Hydrolase

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH37, Glycoside Hydrolase Family 37

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TrehalaseUniRule annotation (EC:3.2.1.28UniRule annotation)
Alternative name(s):
Alpha-trehalose glucohydrolaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTC1Imported
Ordered Locus Names:Cd36_25660Imported
ORF Names:CD36_25660Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573826 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002605 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome R

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000160032, Cd36_25660

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
42374.XP_002421663.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 263Trehalase_Ca-biInterPro annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni39 – 176DisorderedSequence analysisAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 105PolarSequence analysisAdd BLAST43
Compositional biasi119 – 139PolyampholyteSequence analysisAdd BLAST21
Compositional biasi140 – 158PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0602, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006451_1_1_1

KEGG Orthology (KO)

More...
KOi
K01194

Database of Orthologous Groups

More...
OrthoDBi
417479at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR012341, 6hp_glycosidase-like_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR008162, Pyrophosphatase
IPR011120, Trehalase_Ca-bd

The PANTHER Classification System

More...
PANTHERi
PTHR23403, PTHR23403, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00744, GLHYDRLASE37

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208, SSF48208, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00387, PPASE, 1 hit
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9WKQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTKNHRRMS STSSDDDPFD VAEKYYGEER KKKLNRVRTF SAFESTKFGA
60 70 80 90 100
GPISPLRSTY EPPPSIKETS EPLSSSSSSS PPTLTPQSSQ VQFNLGVGKT
110 120 130 140 150
KNGSAIHSDS ESEEGEEVDP VSSATKGERN EKDPFDTTDS KLENNNSTEH
160 170 180 190 200
SSTSREIIPH PTGFHGSPEE SAPRRKPSII PIYHDNISRD SVIRNANTPT
210 220 230 240 250
TYNREKFHLR RGSLDESTYV RPKKYYINDV QGTLKELLAN EDTDNNCQIT
260 270 280 290 300
IEDTGPKVLR LGTANSLGIN QSTIRGTYRL SNLLQELTIA SRFGRHQIVL
310 320 330 340 350
DEARLSENPV DRMKRLISTS FWNNLTRVIT KENIVEMAKD TKIKESWIDE
360 370 380 390 400
QGELHENQES HRIYVPYNRK DQYDFFQLIK SHRTDVQLDV QYLPKKIDAD
410 420 430 440 450
YIKSINKKPG LLSIATRPDP ETPGNLISWP YVVPGGRFNE LYGWDSYMET
460 470 480 490 500
LGLLTDVKID PSGNPCNIKH LELARGMAEN FIYEIHHYGK ILNANRSYYL
510 520 530 540 550
GRSQPPFLTD MALRIFNKTI EVAPESMDDA IDFLKRATLA AIKEYETIWC
560 570 580 590 600
AHPRLDDKTG LSCYHPEGKG VPPETEPTHF NAVLKPYLAK YGGIDQLDFI
610 620 630 640 650
EKYNSGEIQE PELDEYFLHD RAVRESGHDT SYRLEGKCAY LATVDLNSLL
660 670 680 690 700
YKYENDIAFI LQSFFNDNLQ DPFANDKTHS SKIWLERSHQ RKLNVDKYLW
710 720 730 740 750
NEQDCIYYDY NVELQQQTNY ESATTFWPLY AKLASPEQAA KLIDQSLHKF
760 770 780 790 800
EEHGGLVAGT LKSRGEVGLT RPSRQWDYPF GWAPQQILAW IGLVNYGYDG
810 820 830 840 850
IARRLAYRWL FMMTKSFVDY NGVIVEKYNV TKGAVPHRVD AEYGNQGLDF
860 870 880 890 900
KGVATEGFGW VNASYLFGLT FLNLYAQRAL GSLTPPEIFL RNMHPEQRKQ

YK
Length:902
Mass (Da):103,173
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F531B1EAF6A69B6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FM992695 Genomic DNA Translation: CAX39601.1

NCBI Reference Sequences

More...
RefSeqi
XP_002421663.1, XM_002421618.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAX39601; CAX39601; CD36_25660

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8050071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cdu:CD36_25660

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992695 Genomic DNA Translation: CAX39601.1
RefSeqiXP_002421663.1, XM_002421618.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi42374.XP_002421663.1

Protein family/group databases

CAZyiGH37, Glycoside Hydrolase Family 37

Genome annotation databases

EnsemblFungiiCAX39601; CAX39601; CD36_25660
GeneIDi8050071
KEGGicdu:CD36_25660

Organism-specific databases

CGDiCAL0000160032, Cd36_25660

Phylogenomic databases

eggNOGiKOG0602, Eukaryota
HOGENOMiCLU_006451_1_1_1
KOiK01194
OrthoDBi417479at2759

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928, 6-hairpin_glycosidase_sf
IPR012341, 6hp_glycosidase-like_sf
IPR001661, Glyco_hydro_37
IPR018232, Glyco_hydro_37_CS
IPR008162, Pyrophosphatase
IPR011120, Trehalase_Ca-bd
PANTHERiPTHR23403, PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204, Trehalase, 1 hit
PF07492, Trehalase_Ca-bi, 1 hit
PRINTSiPR00744, GLHYDRLASE37
SUPFAMiSSF48208, SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00387, PPASE, 1 hit
PS00927, TREHALASE_1, 1 hit
PS00928, TREHALASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9WKQ2_CANDC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9WKQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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