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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184PROSITE-ProRule annotation1
Active sitei394PROSITE-ProRule annotation1
Active sitei452PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CD36_70870
OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Taxonomic identifieri573826 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000002605 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000171205 Cd36_70870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 543LumenalSequence analysisAdd BLAST524
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 686CytoplasmicSequence analysisAdd BLAST122

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041190920 – 686Pheromone-processing carboxypeptidase KEX1Add BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiB9WJJ7

Interactioni

Protein-protein interaction databases

STRINGi573826.XP_002421307.1

Structurei

3D structure databases

SMRiB9WJJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi522 – 530Poly-Ser9

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B9WJJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLLPTFII FIYTLLVSAL PTKEGSDPKA AKKYLVSDLP GLHDNITPDD
60 70 80 90 100
SIPLMFAGQL EIYPESNTHY FFWKFSDSNQ ETITNRTIFW LNGGPGCSSM
110 120 130 140 150
DGALLETGPF RINSQQQVIS NNGSWHKSGD IIYVDQPAGT GFSYSDTYIT
160 170 180 190 200
DLDQVANYFL KFMEAYYELF PQEINNEIYF AGESYAGQYI PYIANAILQR
210 220 230 240 250
NKKLHEGEQK YDLRGVLIGN GWVSPNEQSL SYLPFFKDHG LIDIHHPKWA
260 270 280 290 300
TLLAKHEQCQ KIVNKIDSTF DDGTVHYYEV SSSTCEAILT DLLEYTQDTA
310 320 330 340 350
NDKNQQCINM YDYTLRDSYP SCGMNWPNEL VNVGPFLRQE KVMHQLNLIN
360 370 380 390 400
LKKWNECNGK VGRTFQARHS IPSVHLLPEL AKEIPVMLFN GANDIICNSQ
410 420 430 440 450
GVLSYLQKLQ WNGETGFINK DNQISWVYDN KEVGYMLWER NISFINIYNS
460 470 480 490 500
SHMVPYDLPD VSRALIDLIT GEYDEKDVDG KKSFVTYPLG SRKENDESKN
510 520 530 540 550
PVESPSQTID PIISSSSSSV ESSLSSSSAS ATDSDSTSSK FTRLIQLAVI
560 570 580 590 600
LVIFWGVYVL YASYKSRPSS IIKKPTNNTS NITRSSTGKK KNVQWADQLN
610 620 630 640 650
QFEDDERNQE SNQGIIAKAI GKITGSKDTR GRYAPVHREN DNEYIDDIEL
660 670 680
GEGISDPNVD EFIIGSDDDD EEEQPRSDPA THKSVS
Length:686
Mass (Da):77,574
Last modified:March 24, 2009 - v1
Checksum:iD6525FC9603CA262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992694 Genomic DNA Translation: CAX40641.1
RefSeqiXP_002421307.1, XM_002421262.1

Genome annotation databases

EnsemblFungiiCAX40641; CAX40641; CD36_70870
GeneIDi8049274
KEGGicdu:CD36_70870

Similar proteinsi

Entry informationi

Entry nameiKEX1_CANDC
AccessioniPrimary (citable) accession number: B9WJJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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