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Entry version 66 (12 Aug 2020)
Sequence version 1 (24 Mar 2009)
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Protein

Lon protease homolog 2, peroxisomal

Gene

CD36_85340

Organism
Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1099UniRule annotation1
Active sitei1142UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi721 – 728ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lon protease homolog 2, peroxisomalUniRule annotation (EC:3.4.21.53UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CD36_85340
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573826 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002605 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000160445, Cd36_85340

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003957921 – 1247Lon protease homolog 2, peroxisomalAdd BLAST1247

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B9WEC4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
42374.XP_002419441.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 400Lon N-terminalPROSITE-ProRule annotationAdd BLAST379
Domaini989 – 1230Lon proteolyticPROSITE-ProRule annotationAdd BLAST242

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2004, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004109_4_0_1

KEGG Orthology (KO)

More...
KOi
K01338

Database of Orthologous Groups

More...
OrthoDBi
528132at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.230.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03121, lonp2_euk, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR008269, Lon_proteolytic
IPR027065, Lon_Prtase
IPR003111, Lon_substr-bd
IPR027501, Lonp2_euk
IPR027417, P-loop_NTPase
IPR008268, Peptidase_S16_AS
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR10046, PTHR10046, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF05362, Lon_C, 1 hit
PF02190, LON_substr_bdg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF54211, SSF54211, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51787, LON_N, 1 hit
PS51786, LON_PROTEOLYTIC, 1 hit
PS01046, LON_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9WEC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKYNNNNYA NKATNLKQQV VLPTYTLDSN LVLLPGIMYN VTFSRFKAAA
60 70 80 90 100
LLYRYKNFIS QVSIINNLLS EYDFNSGNSN EEERSETEQK IEQSSLGQPE
110 120 130 140 150
TYHEINPSVI STEAVEGIKE FFQYETNMKT GRGGKGEKEA KSTNDGIKEF
160 170 180 190 200
DWLTLAIIPN LDKIKDPETN YSIGDAAKLT NVVTVARIIG IVDDSTNIKL
210 220 230 240 250
TLQAITRGVQ ITDDSKMNQH KNGLKTNEQV IGIDWNHNVS DLKGKFNALQ
260 270 280 290 300
KNYQQLFQSI DKFLIDYREA LDYNKNNSNN KNGNLSLIKG NATINNNKNS
310 320 330 340 350
DDKSNQDIKS QNLLTLNPLA NALYMQLVGS KDFNKAFHRL EKLFSQVSKN
360 370 380 390 400
DEYKIDNETY LRLVDLTCGI LPFPNFQKLA LLNKYKLDDR SVLINEMILQ
410 420 430 440 450
LIQIFENLQT NNSFVNNWFH SEATNIQKAN VVANQLKSIR NLLEGMTKNR
460 470 480 490 500
PIKSNKRNPG PASSSGPSFS NGKSSPGRAN ARPKSNHQDG FNGNDGDYND
510 520 530 540 550
VDDDDDGDED LKAIFNFIKH KLPTISTLSA DSKRLILKDF KRVKASANSP
560 570 580 590 600
GGGGNSDFHV LRNYLEIVMD IPWDNYVTKF KSNKDIDLKL AKKQLDDDHY
610 620 630 640 650
GLEHVKKRLI QYLVVLKLLG INAEKDQSDK SQPIKDNSKD SPNSSSKALT
660 670 680 690 700
KSPTSSLSRK TISSIVIANK DETYLAKQQA KTTNQKSITE AKTNPSTTMI
710 720 730 740 750
TSNESIHVSK NNKSPIIMLA GPPGTGKTSL AKSIASALGR NFQRISLGGI
760 770 780 790 800
KDESEIRGHR RTYVGAMPGL LIQALRKSRC MNPVILLDEI DKVIGGNNSG
810 820 830 840 850
GVNKFNGDPS AALLEVLDPE QNNTFIDHYL GFPIDLSQVI FICTANDPWN
860 870 880 890 900
MTRPLLDRLE TIEIGAYDYN EKLIIGKKYL LPRQIKRNGF PVVDTKKMTT
910 920 930 940 950
VVAGSSNQDE FIRINDATMK KVILDYTRGE AGVRNFERRL GTLCRFKAVE
960 970 980 990 1000
YCEWLNKDIK NYNPIIDEND LPIYLGVPYS SGDVTTEGTV GVGVVHGLSY
1010 1020 1030 1040 1050
NSDGSGSVLV FESIGFDRRI SNKEHNGGNG ATLNMTGRLG EVLMESGKIG
1060 1070 1080 1090 1100
LVFIKSMIYK NILKFDNNNN NKHLLLDKYN NLDIHMHVPM GSVSKDGPSA
1110 1120 1130 1140 1150
GVTMALSFLS VLLDKPVPSD IAMTGEITLR GIILPIGGVK EKLMGAHLNS
1160 1170 1180 1190 1200
NIKRMIVPRE NRKDLIKEYS RSIEEAGEVL DHHLINDLIK DNEDKEFKLT
1210 1220 1230 1240
QVEEYYQNKY GISLFYAKEF YDIIKIVWNE DEVLLKQDNS RLLEYHI
Length:1,247
Mass (Da):139,848
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FD55A67A54E534C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FM992690 Genomic DNA Translation: CAX43035.1

NCBI Reference Sequences

More...
RefSeqi
XP_002419441.1, XM_002419396.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAX43035; CAX43035; CD36_85340

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8047097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cdu:CD36_85340

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM992690 Genomic DNA Translation: CAX43035.1
RefSeqiXP_002419441.1, XM_002419396.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi42374.XP_002419441.1

Proteomic databases

PRIDEiB9WEC4

Genome annotation databases

EnsemblFungiiCAX43035; CAX43035; CD36_85340
GeneIDi8047097
KEGGicdu:CD36_85340

Organism-specific databases

CGDiCAL0000160445, Cd36_85340

Phylogenomic databases

eggNOGiKOG2004, Eukaryota
HOGENOMiCLU_004109_4_0_1
KOiK01338
OrthoDBi528132at2759

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_03121, lonp2_euk, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR008269, Lon_proteolytic
IPR027065, Lon_Prtase
IPR003111, Lon_substr-bd
IPR027501, Lonp2_euk
IPR027417, P-loop_NTPase
IPR008268, Peptidase_S16_AS
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046, PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF05362, Lon_C, 1 hit
PF02190, LON_substr_bdg, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF54211, SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS51787, LON_N, 1 hit
PS51786, LON_PROTEOLYTIC, 1 hit
PS01046, LON_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLONP2_CANDC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9WEC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 24, 2009
Last modified: August 12, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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