UniProtKB - B9VQL5 (B9VQL5_DANRE)
Protein
Submitted name:
Neuregulin 2b
Gene
nrg2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
GO - Biological processi
- animal organ development Source: GO_Central
- intracellular signal transduction Source: GO_Central
- nervous system development Source: InterPro
Keywordsi
Molecular function | Growth factorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Neuregulin 2bImported |
Gene namesi | Name:nrg2bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-090205-2, nrg2b |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 203 – 224 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 148 ↔ 165 | PROSITE-ProRule annotation | ||
Disulfide bondi | 167 ↔ 176 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationInteractioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 122 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 136 – 177 | EGF-likeInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 286 – 318 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 484 – 599 | DisorderedSequence analysisAdd BLAST | 116 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 36 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 286 – 306 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 545 – 592 | PolarSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the neuregulin family.ARBA annotation
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 313400at2759 |
PhylomeDBi | B9VQL5 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C |
PANTHERi | PTHR11100, PTHR11100, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
B9VQL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREISYRNCG RMRERTTDRR RKDGLREGKK RASAPKVKPM DSQWLQEGKK
60 70 80 90 100
LTLKCEAVGN PSPSFNWYKD GSQLRQKKTV KIKTNKKNSK LHISKVRLED
110 120 130 140 150
SGNYTCVVEN SLGRENATSF VSVQSITTTL SPGSSHARKC NETEKTYCIN
160 170 180 190 200
GGDCYFIHGI NQLSCKCPND YTGERCQTSV MAGFYKHLGI EIMEAEELYQ
210 220 230 240 250
KRVLTITGIC VALLVVGIVC VVAYRKTKKQ RKKMHNHLHQ NMCAEHPNRM
260 270 280 290 300
LANGPNHPGP GPEEIPMVDY ISKNVPATER VVRHGTETSG NFSGSRMSSR
310 320 330 340 350
SHHTSTASHT SSHRHEERTW SMEWTDSIHS DCQSGALSSS VGTSKCSSSA
360 370 380 390 400
CMEARARRVA YCGYPDATQC SLQYGDSYDS LRDSPHSDRY VSALTTPARL
410 420 430 440 450
SPVDFHSSLP PQVPTFQITT PNASHALSLP PAASAIAMAA YSPDDDQPLL
460 470 480 490 500
YRYRRSRRPY YAAESTGSLP SSPYRFVDDE DYETTQEYMS SREQPKKSSG
510 520 530 540 550
SRRWRRRLRI NGHTPGPRNY SSQSCLSDSE WEDEEVGDLG HGESTPFLSM
560 570 580 590
QNMNATEPAT IYRPNDTRTF SNTGRSGSRP NVQANKLTQS RFRPDNAPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ593494 mRNA Translation: ACM45588.1 |
RefSeqi | NP_001138563.1, NM_001145091.2 |
Genome annotation databases
GeneIDi | 100270726 |
KEGGi | dre:100270726 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ593494 mRNA Translation: ACM45588.1 |
RefSeqi | NP_001138563.1, NM_001145091.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 100270726 |
KEGGi | dre:100270726 |
Organism-specific databases
CTDi | 100270726 |
ZFINi | ZDB-GENE-090205-2, nrg2b |
Phylogenomic databases
OrthoDBi | 313400at2759 |
PhylomeDBi | B9VQL5 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR040180, Neuregulin IPR002154, Neuregulin_C |
PANTHERi | PTHR11100, PTHR11100, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02158, Neuregulin, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B9VQL5_DANRE | |
Accessioni | B9VQL5Primary (citable) accession number: B9VQL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 24, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |