LF - Lactotransferrin - Bos taurus (Bovine)

Functionⁱ

The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.ARBA annotation

Transferrins are iron binding transport proteins which can bind two Fe³⁺ ions in association with the binding of an anion, usually bicarbonate.ARBA annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	92	UniRule annotation		1
Active siteⁱ	278	NucleophileUniRule annotation		1

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity Source: Ensembl
heparin binding Source: Ensembl
iron ion binding Source: Ensembl
lipopolysaccharide binding Source: Ensembl
protein serine/threonine kinase activator activity Source: Ensembl
serine-type endopeptidase activity Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

antibacterial humoral response Source: Ensembl
antifungal humoral response Source: Ensembl
antimicrobial humoral immune response mediated by antimicrobial peptide Source: Ensembl
bone morphogenesis Source: Ensembl
defense response to Gram-negative bacterium Source: Ensembl
innate immune response in mucosa Source: Ensembl
killing of cells of other organism Source: Ensembl
membrane disruption in other organism Source: Ensembl
negative regulation by host of viral process Source: Ensembl
negative regulation of ATPase activity Source: Ensembl
negative regulation of cysteine-type endopeptidase activity Source: Ensembl
negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
negative regulation of single-species biofilm formation in or on host organism Source: Ensembl
negative regulation of viral genome replication Source: Ensembl
ossification Source: UniProtKB-KW
positive regulation of chondrocyte proliferation Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of osteoblast proliferation Source: Ensembl
positive regulation of toll-like receptor 4 signaling pathway Source: Ensembl
regulation of tumor necrosis factor production Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine proteaseARBA annotation
Biological process	ImmunityARBA annotation, OsteogenesisARBA annotation, TransportARBA annotation
Ligand	Metal-bindingARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: LactotransferrinARBA annotation
Gene namesⁱ	Name:LFImported
Organismⁱ	Bos taurus (Bovine)Imported
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Pathology & Biotechⁱ

Protein family/group databases

Allergomeⁱ	1065, Bos d LF

Allergomeⁱ

1065, Bos d LF

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_5009949412	20 – 708	LactotransferrinSequence analysisAdd BLAST		689

Keywords - PTMⁱ

Disulfide bondARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000001292, Expressed in spermatocyte and 17 other tissues
ExpressionAtlasⁱ	B9VPZ5, baseline

Structureⁱ

3D structure databases

SMRⁱ	B9VPZ5
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 352	Transferrin-likeInterPro annotationAdd BLAST		328
Domainⁱ	364 – 693	Transferrin-likeInterPro annotationAdd BLAST		330

Sequence similaritiesⁱ

Belongs to the transferrin family.UniRule annotation

Keywords - Domainⁱ

RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

HOGENOMⁱ	CLU_011309_1_0_1
OMAⁱ	KSVRWCT
Database of Orthologous Groups More...OrthoDBⁱ	232859at2759

Family and domain databases

InterProⁱ	View protein in InterPro IPR030684, Lactotransferrin IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00405, Transferrin, 2 hits
PIRSFⁱ	PIRSF500683, Lactotransferrin, 1 hit PIRSF002549, Transferrin, 1 hit
PRINTSⁱ	PR00422, TRANSFERRIN
SMARTⁱ	View protein in SMART SM00094, TR_FER, 2 hits
PROSITEⁱ	View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 2 hits PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 2 hits PS51408, TRANSFERRIN_LIKE_4, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

B9VPZ5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLFVPALLS LGALGLCLAA PRKNVRWCTI SQPEWFKCRR WQWRMKKLGA 
        60         70         80         90        100
PSITCVRRAF ALECIRAIAE KKADAVTLDG GMVFEAGRDP YKLRPVAAEI 
       110        120        130        140        150
YGTKESPQTH YYAVAVVKKG SNFQLDQLQG RKSCHTGLGR SAGWIIPMGI 
       160        170        180        190        200
LRPYLSWTES LEPLQGAVAK FFSASCVPCI DRQAYPNLCQ LCKGEGENQC 
       210        220        230        240        250
ACSSREPYFG YSGAFKCLQD GAGDVAFVKE TTVFENLPEK ADRDQYELLC 
       260        270        280        290        300
LNNSRAPVDA FKECHLAQVP SHAVVARSVD GKEDLIWKLL SKAQEKFGKN 
       310        320        330        340        350
KSRSFQLFGS PPGQRDLLFK DSALGFLRIP SKVDSALYLG SRYLTTLKNL 
       360        370        380        390        400
RETAEEVKAR YTRVVWCAVG PEEQKKCQQW SQQSGQNVTC ATASTTDDCI 
       410        420        430        440        450
VLVLKGEADA LNLDGGYIYT AGKCGLVPVL AENRKSSKHS SLDCVLRPTE 
       460        470        480        490        500
GYLAVAVVKK ANEGLTWNSL KDKKSCHTAV DRTAGWNIPM GLIVNQTGSC 
       510        520        530        540        550
AFDEFFSQSC APGADPKSRL CALCAGDDQG LDKCVPNSKE KYYGYTGAFR 
       560        570        580        590        600
CLAEDVGDVA FVKNDTVWEN TNGESTADWA KNLNREDFRL LCLDGTRKPV 
       610        620        630        640        650
TEAQSCHLAV APNHAVVSRS DRAAHVKQVL LHQQALFGKN GKNCPDKFCL 
       660        670        680        690        700
FKSETKNLLF NDNTECLAKL GGRPTYEEYL GTEYVTAIAN LKKCSTSPLL 

EACAFLTR

Length:708

Mass (Da):78,056

Last modified:March 24, 2009 - v1

Checksum:ⁱC6FD7FC15D68E93F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ589071 mRNA Translation: ACM24792.1
NCBI Reference Sequences More...RefSeqⁱ	NP_851341.1, NM_180998.2 XP_015315141.1, XM_015459655.1

Genome annotation databases

GeneIDⁱ	280846
KEGGⁱ	bta:280846

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B9VPZ5	Lactotransferrin	)	BOVIN		708	UniRef100_P24627
Lactotransferrin		BOBOX		708
+1

Protein	Similar proteins		Species	Score	Length	Source
B9VPZ5	Lactotransferrin	)	BOVIN		708	UniRef90_P24627
Lactotransferrin	)	BUBBU		708
Lactotransferrin		BOBOX		708
Lactotransferrin		wild yak		730
Lactoferrin (Fragment)		BOSIN		58
+73

Protein	Similar proteins		Species	Score	Length	Source
B9VPZ5	Lactotransferrin	)	HUMAN		710	UniRef50_P02788
Lactotransferrin		MOUSE		707
Lactotransferrin	)	CAMDR		708
Lactotransferrin (Fragment)	)	HORSE		695
Lactotransferrin	)	BUBBU		708
+495

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ589071 mRNA Translation: ACM24792.1
RefSeqⁱ	NP_851341.1, NM_180998.2 XP_015315141.1, XM_015459655.1

3D structure databases

SMRⁱ	B9VPZ5
ModBaseⁱ	Search...

Protein family/group databases

Allergomeⁱ	1065, Bos d LF

Allergomeⁱ

1065, Bos d LF

Genome annotation databases

GeneIDⁱ	280846
KEGGⁱ	bta:280846

Organism-specific databases

CTDⁱ	4057

CTDⁱ

4057

Phylogenomic databases

HOGENOMⁱ	CLU_011309_1_0_1
OMAⁱ	KSVRWCT
OrthoDBⁱ	232859at2759

Gene expression databases

Bgeeⁱ	ENSBTAG00000001292, Expressed in spermatocyte and 17 other tissues
ExpressionAtlasⁱ	B9VPZ5, baseline

Family and domain databases

InterProⁱ	View protein in InterPro IPR030684, Lactotransferrin IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS
Pfamⁱ	View protein in Pfam PF00405, Transferrin, 2 hits
PIRSFⁱ	PIRSF500683, Lactotransferrin, 1 hit PIRSF002549, Transferrin, 1 hit
PRINTSⁱ	PR00422, TRANSFERRIN
SMARTⁱ	View protein in SMART SM00094, TR_FER, 2 hits
PROSITEⁱ	View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 2 hits PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 2 hits PS51408, TRANSFERRIN_LIKE_4, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B9VPZ5_BOVIN
Accessionⁱ	B9VPZ5Primary (citable) accession number: B9VPZ5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 24, 2009
	Last sequence update:	March 24, 2009
	Last modified:	December 2, 2020
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - B9VPZ5 (B9VPZ5_BOVIN)

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Lactotransferrin

LF

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ