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Entry version 91 (02 Jun 2021)
Sequence version 1 (24 Mar 2009)
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Protein

Core protein precursor

Gene
N/A
Organism
Recombinant Hepatitis C virus HK6a/JFH-1
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.ARBA annotation EC:3.4.21.98

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, Ion channel, Multifunctional enzymeARBA annotation, Nucleotidyltransferase, Protease, RibonucleoproteinARBA annotation, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Serine proteaseARBA annotation, Thiol proteaseARBA annotation, Transferase, Viral ion channelARBA annotation, Viral nucleoproteinARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, ApoptosisARBA annotation, Clathrin-mediated endocytosis of virus by hostARBA annotation, Fusion of virus membrane with host endosomal membraneARBA annotation, Fusion of virus membrane with host membrane, G1/S host cell cycle checkpoint dysregulation by virusARBA annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MAVS by virusARBA annotation, Inhibition of host RLR pathway by virus, Inhibition of host STAT1 by virusARBA annotation, Inhibition of host TRAFs by virusARBA annotation, Interferon antiviral system evasionARBA annotation, Ion transport, Modulation of host cell cycle by virus, Transcription, Transcription regulationARBA annotation, Transport, Viral attachment to host cellARBA annotation, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replicationARBA annotation, Virus endocytosis by host, Virus entry into host cell
LigandATP-binding, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding, ZincARBA annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S29.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core protein precursorARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.21.98ARBA annotation, EC:3.6.1.15ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Envelope glycoprotein E1ARBA annotation
Envelope glycoprotein E2ARBA annotation
Genome polyproteinARBA annotation
Gp32ARBA annotation
HepacivirinARBA annotation
Mature core proteinARBA annotation
NS1ARBA annotation
NS3 helicaseARBA annotation
NS3 proteaseARBA annotation
NS3PARBA annotation
NS5BARBA annotation
Non-structural protein 4AARBA annotation
Non-structural protein 4BARBA annotation
Non-structural protein 5AARBA annotation
Protease NS2ARBA annotation
RNA-directed RNA polymeraseARBA annotation
Serine protease/helicase NS3ARBA annotation
Viroporin p7ARBA annotation
Viroporin p70ARBA annotation
gp35ARBA annotation
gp68ARBA annotation
gp70ARBA annotation
p21ARBA annotation
p23ARBA annotation
p27ARBA annotation
p56/58ARBA annotation
p68ARBA annotation
p8ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRecombinant Hepatitis C virus HK6a/JFH-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri595609 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaFlasuviricetesAmarilloviralesFlaviviridaeHepacivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000107090 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei265 – 288HelicalSequence analysisAdd BLAST24
Transmembranei344 – 363HelicalSequence analysisAdd BLAST20
Transmembranei724 – 747HelicalSequence analysisAdd BLAST24
Transmembranei759 – 784HelicalSequence analysisAdd BLAST26
Transmembranei791 – 809HelicalSequence analysisAdd BLAST19
Transmembranei821 – 841HelicalSequence analysisAdd BLAST21
Transmembranei1666 – 1689HelicalSequence analysisAdd BLAST24
Transmembranei1830 – 1851HelicalSequence analysisAdd BLAST22
Transmembranei1857 – 1876HelicalSequence analysisAdd BLAST20
Transmembranei1888 – 1908HelicalSequence analysisAdd BLAST21
Transmembranei3016 – 3034HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Capsid proteinARBA annotation, Host cell membraneARBA annotation, Host cytoplasmARBA annotation, Host endoplasmic reticulumARBA annotation, Host lipid dropletARBA annotation, Host membrane, Host mitochondrionARBA annotation, Host nucleusARBA annotation, Membrane, Viral envelope proteinARBA annotation, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi429 ↔ 505Combined sources
Disulfide bondi452 ↔ 626Combined sources
Disulfide bondi496 ↔ 566Combined sources
Disulfide bondi510 ↔ 554Combined sources
Disulfide bondi613 ↔ 650Combined sources

Keywords - PTMi

AcetylationARBA annotation, Disulfide bondARBA annotation, GlycoproteinARBA annotation, Lipoprotein, PalmitateARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B9V0E2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini909 – 1032Peptidase C18InterPro annotationAdd BLAST124
Domaini1033 – 1214Peptidase S29InterPro annotationAdd BLAST182
Domaini1223 – 1375Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini1367 – 1544Helicase C-terminalInterPro annotationAdd BLAST178
Domaini2658 – 2776RdRp catalyticInterPro annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 76DisorderedSequence analysisAdd BLAST76
Regioni1483 – 1503DisorderedSequence analysisAdd BLAST21
Regioni2194 – 2215DisorderedSequence analysisAdd BLAST22
Regioni2302 – 2335DisorderedSequence analysisAdd BLAST34
Regioni2354 – 2434DisorderedSequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 61Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2201 – 2215Polar residuesSequence analysisAdd BLAST15
Compositional biasi2354 – 2373Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hepacivirus polyprotein family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit
2.40.10.10, 1 hit
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR002521, HCV_core_C
IPR002522, HCV_core_N
IPR002519, HCV_env
IPR002531, HCV_NS1
IPR002518, HCV_NS2
IPR042205, HCV_NS2_C
IPR042209, HCV_NS2_N
IPR000745, HCV_NS4a
IPR001490, HCV_NS4b
IPR002868, HCV_NS5a
IPR013193, HCV_NS5a_1B_dom
IPR038568, HCV_NS5A_1B_sf
IPR024350, HCV_NS5a_C
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR013192, NS5A_1a
IPR038170, NS5A_1a_sf
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR004109, Peptidase_S29_NS3
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF01543, HCV_capsid, 1 hit
PF01542, HCV_core, 1 hit
PF01539, HCV_env, 1 hit
PF01560, HCV_NS1, 1 hit
PF01538, HCV_NS2, 1 hit
PF01006, HCV_NS4a, 1 hit
PF01001, HCV_NS4b, 1 hit
PF01506, HCV_NS5a, 1 hit
PF08300, HCV_NS5a_1a, 1 hit
PF08301, HCV_NS5a_1b, 1 hit
PF12941, HCV_NS5a_C, 1 hit
PF02907, Peptidase_S29, 1 hit
PF00998, RdRP_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51693, HCV_NS2_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51822, HV_PV_NS3_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9V0E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLPKPQRK TKRNTNRRPM DVKFPGGGQI VGGVYLLPRR GPRLGVRATR
60 70 80 90 100
KTSERSQPRG RRQPIPKARQ PQGRHWAQPG YPWPLYGNEG CGWAGWLLSP
110 120 130 140 150
RGSRPHWGPN DPRRRSRNLG KVIDTLTCGF ADLMGYIPVV GAPLGGVAAA
160 170 180 190 200
LAHGVRAIED GINYATGNLP GCSFSIFLLA LLSCLTTPAS ALTYGNSSGL
210 220 230 240 250
YHLTNDCPNS SIVLEADAMI LHLPGCLPCV RVNNNQSICW HAVSPTLAIP
260 270 280 290 300
NASTPATGFR RHVDLLAGAA VVCSSLYIGD LCGSLFLAGQ LFTFQPRRHW
310 320 330 340 350
TVQDCNCSIY TGHVTGHRMA WDMMMNWSPT TTLVLSSILR VPEICASVIF
360 370 380 390 400
GGHWGILLAV AYFGMAGNWL KVLAVLFLFA GVEATTTIGH QVGRTTGGLA
410 420 430 440 450
SLFSIGPRQN LQLINTNGSW HINRTALNCN DSLQTGFITS LFYAKNVNSS
460 470 480 490 500
GCPERMAACK PLADFRQGWG QITYKVNISG PSDDRPYCWH YAPRPCDVVS
510 520 530 540 550
ARTVCGPVYC FTPSPVVVGT TDKLGIPTYN WGENETDVFM LESLRPPTGG
560 570 580 590 600
WFGCTWMNST GFTKTCGAPP CQIVPGDYNS SANELLCPTD CFRKHPEATY
610 620 630 640 650
QRCGSGPWIT PRCLVDYPYR LWHYPCTVNF TLHKVRMFVG GIEHRFDAAC
660 670 680 690 700
NWTRGERCDL HDRDRIEMSP LLFSTTQLAI LPCSFSTMPA LSTGLIHLHQ
710 720 730 740 750
NIVDVQYLYG VSSSVTSWVV KWEYIVLVFL VLADARICTC LWLMLLITNV
760 770 780 790 800
EAAVERLVVL NAASAAGTAG WWWAVLFLCC AWYVKGRLVP ACTYMALGMW
810 820 830 840 850
PLLLTILALP RRAYAMDNEQ AASLGAVGLL VLTIFTITPM YKKLLTCSIW
860 870 880 890 900
WNQYFLARAE AMIHEWVPDL RVRGGRDSII LLTCLLHPQL GFEVTKILLA
910 920 930 940 950
ILAPLYILQY SLLKVPYFVR AHVLLRACLL VRRLAGGKYV QACLLRLGAW
960 970 980 990 1000
TGTFVYDHLA PLSDWASDGL RDLAVAIEPV IFSPMEKKII TWGADTAACG
1010 1020 1030 1040 1050
DILSGLPVSA RLGNLVLLGP ADDMQRGGWK LLAPITAYAQ QTRGLLGAIV
1060 1070 1080 1090 1100
VSMTGRDRTE QAGEVQILST VSQSFLGTTI SGVLWTVYHG AGNKTLAGLR
1110 1120 1130 1140 1150
GPVTQMYSSA EGDLVGWPSP PGTKSLEPCK CGAVDLYLVT RNADVIPARR
1160 1170 1180 1190 1200
RGDKRGALLS PRPISTLKGS SGGPVLCPRG HVVGLFRAAV CSRGVAKSID
1210 1220 1230 1240 1250
FIPVETLDVV TRSPTFSDNS TPPAVPQTYQ VGYLHAPTGS GKSTKVPVAY
1260 1270 1280 1290 1300
AAQGYKVLVL NPSVAATLGF GAYLSKAHGI NPNIRTGVRT VMTGEAITYS
1310 1320 1330 1340 1350
TYGKFLADGG CASGAYDIII CDECHAVDAT SILGIGTVLD QAETAGVRLT
1360 1370 1380 1390 1400
VLATATPPGS VTTPHPDIEE VGLGREGEIP FYGRAIPLSC IKGGRHLIFC
1410 1420 1430 1440 1450
HSKKKCDELA AALRGMGLNA VAYYRGLDVS IIPAQGDVVV VATDALMTGY
1460 1470 1480 1490 1500
TGDFDSVIDC NVAVTQAVDF SLDPTFTITT QTVPQDAVSR SQRRGRTGRG
1510 1520 1530 1540 1550
RQGTYRYVST GERASGMFDS VVLCECYDAG AAWYDLTPAE TTVRLRAYFN
1560 1570 1580 1590 1600
TPGLPVCQDH LEFWEAVFTG LTHIDAHFLS QTKQAGENFA YLVAYQATVC
1610 1620 1630 1640 1650
ARAKAPPPSW DAMWKCLARL KPTLAGPTPL LYRLGPITNE VTLTHPGTKY
1660 1670 1680 1690 1700
IATCMQADLE VMTSTWVLAG GVLAAVAAYC LATGCVSIIG RLHVNQRVVV
1710 1720 1730 1740 1750
APDKEVLYEA FDEMEECASR AALIEEGQRI AEMLKSKIQG LLQQASKQAQ
1760 1770 1780 1790 1800
DIQPAMQASW PKVEQFWARH MWNFISGIQY LAGLSTLPGN PAVASMMAFS
1810 1820 1830 1840 1850
AALTSPLSTS TTILLNIMGG WLASQIAPPA GATGFVVSGL VGAAVGSIGL
1860 1870 1880 1890 1900
GKVLVDILAG YGAGISGALV AFKIMSGEKP SMEDVINLLP GILSPGALVV
1910 1920 1930 1940 1950
GVICAAILRR HVGPGEGAVQ WMNRLIAFAS RGNHVAPTHY VTESDASQRV
1960 1970 1980 1990 2000
TQLLGSLTIT SLLRRLHNWI TEDCPIPCSG SWLRDVWDWV CTILTDFKNW
2010 2020 2030 2040 2050
LTSKLFPKLP GLPFISCQKG YKGVWAGTGI MTTRCPCGAN ISGNVRLGSM
2060 2070 2080 2090 2100
RITGPKTCMN TWQGTFPINC YTEGQCAPKP PTNYKTAIWR VAASEYAEVT
2110 2120 2130 2140 2150
QHGSYSYVTG LTTDNLKIPC QLPSPEFFSW VDGVQIHRFA PTPKPFFRDE
2160 2170 2180 2190 2200
VSFCVGLNSY AVGSQLPCEP EPDADVLRSM LTDPPHITAE TAARRLARGS
2210 2220 2230 2240 2250
PPSEASSSVS QLSAPSLRAT CTTHSNTYDV DMVDANLLME GGVAQTEPES
2260 2270 2280 2290 2300
RVPVLDFLEP MAEEESDLEP SIPSECMLPR SGFPRALPAW ARPDYNPPLV
2310 2320 2330 2340 2350
ESWRRPDYQP PTVAGCALPP PKKAPTPPPR RRRTVGLSES TISEALQQLA
2360 2370 2380 2390 2400
IKTFGQPPSS GDAGSSTGAG AAESGGPTSP GEPAPSETGS ASSMPPLEGE
2410 2420 2430 2440 2450
PGDPDLESDQ VELQPPPQGG GVAPGSGSGS WSTCSEEDDT TVCCSMSYSW
2460 2470 2480 2490 2500
TGALITPCSP EEEKLPINPL SNSLLRYHNK VYCTTSKSAS QRAKKVTFDR
2510 2520 2530 2540 2550
TQVLDAHYDS VLKDIKLAAS KVSARLLTLE EACQLTPPHS ARSKYGFGAK
2560 2570 2580 2590 2600
EVRSLSGRAV NHIKSVWKDL LEDPQTPIPT TIMAKNEVFC VDPAKGGKKP
2610 2620 2630 2640 2650
ARLIVYPDLG VRVCEKMALY DITQKLPQAV MGASYGFQYS PAQRVEYLLK
2660 2670 2680 2690 2700
AWAEKKDPMG FSYDTRCFDS TVTERDIRTE ESIYQACSLP EEARTAIHSL
2710 2720 2730 2740 2750
TERLYVGGPM FNSKGQTCGY RRCRASGVLT TSMGNTITCY VKALAACKAA
2760 2770 2780 2790 2800
GIVAPTMLVC GDDLVVISES QGTEEDERNL RAFTEAMTRY SAPPGDPPRP
2810 2820 2830 2840 2850
EYDLELITSC SSNVSVALGP RGRRRYYLTR DPTTPLARAA WETVRHSPIN
2860 2870 2880 2890 2900
SWLGNIIQYA PTIWVRMVLM THFFSILMVQ DTLDQNLNFE MYGSVYSVNP
2910 2920 2930 2940 2950
LDLPAIIERL HGLDAFSMHT YSHHELTRVA SALRKLGAPP LRVWKSRARA
2960 2970 2980 2990 3000
VRASLISRGG KAAVCGRYLF NWAVKTKLKL TPLPEARLLD LSSWFTVGAG
3010 3020 3030
GGDIFHSVSR ARPRSLLFGL LLLFVGVGLF LLPAR
Length:3,035
Mass (Da):329,148
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AB0A436A187EE7C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ230883 Other RNA Translation: ACM69040.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ230883 Other RNA Translation: ACM69040.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BKBX-ray2.80E412-459[»]
E488-570[»]
E604-651[»]
6BKCX-ray2.60E412-459[»]
E488-570[»]
E604-651[»]
6BKDX-ray3.25E412-459[»]
E488-570[»]
E604-651[»]
6UYFX-ray2.06E412-651[»]
6UYGX-ray3.38E412-651[»]
6WO3X-ray2.38E412-651[»]
6WO4X-ray2.35E412-651[»]
SMRiB9V0E2
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

MEROPSiS29.001

Family and domain databases

Gene3Di1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit
2.40.10.10, 1 hit
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR002521, HCV_core_C
IPR002522, HCV_core_N
IPR002519, HCV_env
IPR002531, HCV_NS1
IPR002518, HCV_NS2
IPR042205, HCV_NS2_C
IPR042209, HCV_NS2_N
IPR000745, HCV_NS4a
IPR001490, HCV_NS4b
IPR002868, HCV_NS5a
IPR013193, HCV_NS5a_1B_dom
IPR038568, HCV_NS5A_1B_sf
IPR024350, HCV_NS5a_C
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR013192, NS5A_1a
IPR038170, NS5A_1a_sf
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR004109, Peptidase_S29_NS3
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV
PfamiView protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF01543, HCV_capsid, 1 hit
PF01542, HCV_core, 1 hit
PF01539, HCV_env, 1 hit
PF01560, HCV_NS1, 1 hit
PF01538, HCV_NS2, 1 hit
PF01006, HCV_NS4a, 1 hit
PF01001, HCV_NS4b, 1 hit
PF01506, HCV_NS5a, 1 hit
PF08300, HCV_NS5a_1a, 1 hit
PF08301, HCV_NS5a_1b, 1 hit
PF12941, HCV_NS5a_C, 1 hit
PF02907, Peptidase_S29, 1 hit
PF00998, RdRP_3, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51693, HCV_NS2_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51822, HV_PV_NS3_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9V0E2_9HEPC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9V0E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 2, 2021
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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