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Entry version 52 (29 Sep 2021)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Diphthamide biosynthesis protein

Gene

BN1205_070480

Organism
Toxoplasma gondii (strain ATCC 50861 / VEG)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Diphthamide biosynthesis proteinImported
Submitted name:
Diphthamide biosynthesis protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BN1205_070480Imported, TGVEG_219460Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50861 / VEG)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri432359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGVEG_219460

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B9QLS6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5811.TGME49_019460

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 96DisorderedSequence analysisAdd BLAST32
Regioni201 – 220DisorderedSequence analysisAdd BLAST20
Regioni329 – 349DisorderedSequence analysisAdd BLAST21
Regioni437 – 486DisorderedSequence analysisAdd BLAST50
Regioni503 – 529DisorderedSequence analysisAdd BLAST27
Regioni655 – 675DisorderedSequence analysisAdd BLAST21
Regioni934 – 993DisorderedSequence analysisAdd BLAST60
Regioni1170 – 1201DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi466 – 486Polar residuesSequence analysisAdd BLAST21
Compositional biasi505 – 523Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2648, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_259255_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B9QLS6

Identification of Orthologs from Complete Genome Data

More...
OMAi
RERGDIC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11840, 1 hit
3.40.50.11860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010014, DHP2
IPR016435, DPH1/DPH2
IPR042263, DPH1/DPH2_1
IPR042265, DPH1/DPH2_3

The PANTHER Classification System

More...
PANTHERi
PTHR10762, PTHR10762, 2 hits
PTHR10762:SF2, PTHR10762:SF2, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01866, Diphthamide_syn, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00032, Radical_SAM_3-amino-3-carboxyp, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00322, diphth2_R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9QLS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREASASPA LGALLLSGGS VETLLRRKSL GGGVRLPCPL CSSVACSSCA
60 70 80 90 100
CVALPQPCSS SPAASARRPS ACGGHQEESP EAALQSSKDL AGGREPTDDF
110 120 130 140 150
FEVDDLVSVF VRNASWRRVA VQLPSEMLRE APWLSSRLRG ACKSGVSLKP
160 170 180 190 200
HSLAEHPDAG THEATLAPEA AETLGAPGSE APGGAKGRAD DQLRKRIKMG
210 220 230 240 250
MHADPAKQTR ETGDKEVGEG DGHEFAKAAA VENVEMTRNM LASTTFFLLG
260 270 280 290 300
DTVHSSCCAD QIAASHIEPH ALVHYGYSCL SWPVTGPAYP LLYRYTSLPL
310 320 330 340 350
NVSHFSCSLC RHLKVYREQQ LAAYREASLR RPVSPQGRPG RGADLSPAGR
360 370 380 390 400
GPLSLVSSGV LGDGLSLSAA LQSCVALRGR LALQLPPSTF RLVSTLGMLC
410 420 430 440 450
ETHSSPLVLV YDVRYHYALP CMLQHIAPLF LAPSPPSSIS TTPPLSSPAS
460 470 480 490 500
ATPPLHARGA HQSVESSEGG ACSGASSPSV EAAHSSTSLQ AAADALAAAA
510 520 530 540 550
AWREDASVRG DRGRTRDTSP QRGDSEFGGD ACLRVECAGS RMAVVGNAVR
560 570 580 590 600
ASGVREVSPS RDNAEGRLFA PLASSGPACA TTPGDWQPTS LCVALAPSAC
610 620 630 640 650
LPSTGFDLRA LEPSVARATA PAPRNEEEVE LDPADLQRRH FASLVISFAA
660 670 680 690 700
AESQASSGES PEASDKASLS SSSSPPPTWF FSLPLSWTPR LVFLGPQLQP
710 720 730 740 750
AQRLVQQQAG GKRSEGISVR ASGASLRISL SAYTAVAGRF VFQAFYRVFD
760 770 780 790 800
RAIGLAPVIP LSASLRMPVG LKAPSPTGPE FVPIEEALGC GWGEAGVVGR
810 820 830 840 850
ERGDICLLYV GPTVDASPSE EQPGQTAGAV PRFTYQSNSH PEAYAFATAF
860 870 880 890 900
ATSGKPGEAR VFEGNETLAG WQAYRELRGK LAPPPLLHRL LLRYGGVDRV
910 920 930 940 950
QVLSYDPTFF TGPPNQEHLV QQFQKLQVCE QQRDEEDAEL ALSPDTTADE
960 970 980 990 1000
AEDLPEEGSR RRSVSRMHQG STVRRGGCPS AASRQEEELT ALEGVGEDEK
1010 1020 1030 1040 1050
EYFRASLCIL DETDRASTAL QKQFSRVTPL AETTRCTALL LLGPQVYGQP
1060 1070 1080 1090 1100
GVLAYVQRQL QKRSEAEARH VVRIAMGEVT PAKLLNFEEV DSACLFGCPE
1110 1120 1130 1140 1150
LCLRVQQEQK ARGLSQLLVL PIDALAATDE AFEWKPSRQP IEADELWQQI
1160 1170 1180 1190 1200
TSQLRCGAVE IEARAAVAAD GKREDDAAGA SEERQGAGDA HPEKDKAAEE
1210 1220 1230 1240 1250
KAGNWKVALR GGSDVLQCVL GQDVLSRTAE RHFKGVSFGE QGHEETGTHL
1260 1270 1280
PPAYQILQGL SGVASEYEKE RHIAHDDSEK TCK
Length:1,283
Mass (Da):136,497
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB62E220D1671296E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN714502 Genomic DNA Translation: CEL78100.1
AAYL02000326 Genomic DNA Translation: ESS28914.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ESS28914; ESS28914; TGVEG_219460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN714502 Genomic DNA Translation: CEL78100.1
AAYL02000326 Genomic DNA Translation: ESS28914.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5811.TGME49_019460

PTM databases

SwissPalmiB9QLS6

Genome annotation databases

EnsemblProtistsiESS28914; ESS28914; TGVEG_219460

Organism-specific databases

VEuPathDBiToxoDB:TGVEG_219460

Phylogenomic databases

eggNOGiKOG2648, Eukaryota
HOGENOMiCLU_259255_0_0_1
InParanoidiB9QLS6
OMAiRERGDIC

Enzyme and pathway databases

UniPathwayiUPA00559

Family and domain databases

Gene3Di3.40.50.11840, 1 hit
3.40.50.11860, 1 hit
InterProiView protein in InterPro
IPR010014, DHP2
IPR016435, DPH1/DPH2
IPR042263, DPH1/DPH2_1
IPR042265, DPH1/DPH2_3
PANTHERiPTHR10762, PTHR10762, 2 hits
PTHR10762:SF2, PTHR10762:SF2, 2 hits
PfamiView protein in Pfam
PF01866, Diphthamide_syn, 1 hit
SFLDiSFLDS00032, Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322, diphth2_R, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9QLS6_TOXGV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9QLS6
Secondary accession number(s): A0A0F7VDV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 29, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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