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Entry version 55 (29 Sep 2021)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Putative aminopeptidase N

Gene

TGVEG_224350

Organism
Toxoplasma gondii (strain ATCC 50861 / VEG)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidaseImported, Hydrolase, MetalloproteaseARBA annotation, Protease
LigandMetal-bindingARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative aminopeptidase NImported (EC:3.4.11.2Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TGVEG_224350Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50861 / VEG)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri432359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGVEG_224350

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei321 – 340HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B9Q7I4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5811.TGME49_024350

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini763 – 977Peptidase_M1InterPro annotationAdd BLAST215
Domaini982 – 1078DUF3458InterPro annotationAdd BLAST97
Domaini1082 – 1411DUF3458_CInterPro annotationAdd BLAST330

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni83 – 111DisorderedSequence analysisAdd BLAST29
Regioni474 – 509DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 33Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1046, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B9Q7I4

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKRWYSQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.10, 1 hit
1.25.50.10, 1 hit
2.60.40.1730, 1 hit
2.60.40.1840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR038438, PepN_Ig-like_sf
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom
IPR012779, Peptidase_M1_pepN
IPR024601, Peptidase_M1_pepN_C
IPR037144, Peptidase_M1_pepN_C_sf
IPR035414, Peptidase_M1_pepN_Ig-like
IPR027268, Peptidase_M4/M1_CTD_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46322, PTHR46322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11940, DUF3458, 1 hit
PF17432, DUF3458_C, 1 hit
PF01433, Peptidase_M1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00756, ALADIPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63737, SSF63737, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02414, pepN_proteo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9Q7I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWRRTKAKG WRPSAGVERK KSTAGRDTRG RHLVRSGASS LGGRAACELW
60 70 80 90 100
RGKTDREAEE RRIEPYALQK SDKSCVQTLL RAGASVKKEK TRPNHGEGDT
110 120 130 140 150
SPTASGSACV RAQRGVQAAS SRLAHQESAG SLPLISFFSS GAAKATASTS
160 170 180 190 200
LWQRETPETA LETPPFLLSA ASRGCPRFGC MDTSQVCQRG LDLRPSCTSK
210 220 230 240 250
KVDFRRFAPA FCGQNATAEL FSSEGKCEKL NRVPPRPPQA AADASAHRLA
260 270 280 290 300
SVHVPFSRVS SPCLQQLFPF DASASSPSRF ASLLAATAST ELPSASPALG
310 320 330 340 350
EATVPKRRSP FAPSLSRHSS VFLLSPTVTL LALLFCLLAF CAFSRGLSLS
360 370 380 390 400
PAETSPLAPP ATRMRPSTSQ LCLRSALPPS LRGKDWCSHA QQRRLDPLAF
410 420 430 440 450
DEKPLAAVSY VSSYPRFCLP AAAPQRKLFS SLTSSSLLPP IPWIAAAIGS
460 470 480 490 500
VSRLSPSPLC AAFASAATVA ASTPQSLGSK MTNATPAEAA PVGASGSVTA
510 520 530 540 550
TETQQQLEGS HVVLKPTKQP VEKHRLDYKP TDFLIDFVDL DFDLYDDRTK
560 570 580 590 600
VTSTLTMHRR EQTPPTDLVL DGEDLELESV ELDGNALSMH STETQKAGDK
610 620 630 640 650
RVYSLDVDGR LVIAADLLPQ EAEKKFKVKT VVYVRPKENL QLMGLYKSGA
660 670 680 690 700
LLVTQCEAEG FRRITYFLDR PDVMSLFKVR LAADEKACPV LLSNGNMVES
710 720 730 740 750
GKVEGEKGRH FAVFEDPFQK PCYLFALVAG DLKSISQSFT TMSGRNVKVS
760 770 780 790 800
IFSEPEDSSK LTWALESVLK SMKWDEERFG REYDLDVFNV VCAKDFNMGA
810 820 830 840 850
MENKGLNIFN AALLLADPST TTDAEYQRIL NVVGHEYFHN WTGNRVTCRD
860 870 880 890 900
WFQLTLKEGL TVFRDQLFTA DMCSAAVKRI EDVVFLRSRQ FAEDSGPMAH
910 920 930 940 950
PIRPETYIAM DNFYTATVYD KGAEVIRMYH TLLGEAGFRK GMDLYFKRHD
960 970 980 990 1000
GKAVTCDDFR AAMADANGRD LGQFERWYLQ AGTPEVTVSE AVFQPERKKF
1010 1020 1030 1040 1050
KLTLKQRTPP TPGQVEKHPF HIPIKVGLIG KTSKRDILSP PTKVLELTEA
1060 1070 1080 1090 1100
EQTFELDAAE DCVLSFLRDF SAPVKVKHEQ TDEDIAFLMA HDSDDFAKWQ
1110 1120 1130 1140 1150
AAHTLASGLL KHRAEQWREK QGEDVEFARL PKIYVEAFKQ TLLEQGRDRS
1160 1170 1180 1190 1200
IQAYTLRLPD RDGVAQEMEP IDPLALKEAT ESVRREVGQL LKSDLLKVYA
1210 1220 1230 1240 1250
SLSAPESEAE ESRDQSEVSR RRLRNVILYF LTGERDKEAA ALAMNHFKSA
1260 1270 1280 1290 1300
KGMTEKYAAL SILCDIEGPE RTAALEQFYR DAKGDPLVLD KWFAVQALSD
1310 1320 1330 1340 1350
VRNVTETVKE LQKHADFTAK NPNRLRALIF SFTRNPQFHN KDGAGYALLA
1360 1370 1380 1390 1400
DSVLAVDRFN PQIAARGAGA FLQWKKYDET RQREMLKQLR RIANAPGLSV
1410
DTLEIVQKAL AGAPEEATA
Length:1,419
Mass (Da):156,885
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED01F72B5CF03882
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAYL02000134 Genomic DNA Translation: ESS32425.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ESS32425; ESS32425; TGVEG_224350

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAYL02000134 Genomic DNA Translation: ESS32425.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5811.TGME49_024350

PTM databases

SwissPalmiB9Q7I4

Genome annotation databases

EnsemblProtistsiESS32425; ESS32425; TGVEG_224350

Organism-specific databases

VEuPathDBiToxoDB:TGVEG_224350

Phylogenomic databases

eggNOGiKOG1046, Eukaryota
InParanoidiB9Q7I4
OMAiFKRWYSQ

Family and domain databases

Gene3Di1.10.390.10, 1 hit
1.25.50.10, 1 hit
2.60.40.1730, 1 hit
2.60.40.1840, 1 hit
InterProiView protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR038438, PepN_Ig-like_sf
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom
IPR012779, Peptidase_M1_pepN
IPR024601, Peptidase_M1_pepN_C
IPR037144, Peptidase_M1_pepN_C_sf
IPR035414, Peptidase_M1_pepN_Ig-like
IPR027268, Peptidase_M4/M1_CTD_sf
PANTHERiPTHR46322, PTHR46322, 1 hit
PfamiView protein in Pfam
PF11940, DUF3458, 1 hit
PF17432, DUF3458_C, 1 hit
PF01433, Peptidase_M1, 1 hit
PRINTSiPR00756, ALADIPTASE
SUPFAMiSSF63737, SSF63737, 1 hit
TIGRFAMsiTIGR02414, pepN_proteo, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9Q7I4_TOXGV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9Q7I4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 29, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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