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Entry version 64 (29 Sep 2021)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Peptidase family M3 domain containing protein

Gene

BN1205_020200

Organism
Toxoplasma gondii (strain ATCC 50861 / VEG)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotationARBA annotation, Protease
LigandMetal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peptidase family M3 domain containing proteinImported
Submitted name:
Peptidase family M3 proteinImported (EC:3.4.24.59Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BN1205_020200Imported, TGVEG_272670Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50861 / VEG)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri432359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGVEG_272670

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B9Q3Z6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5811.TGME49_072670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini978 – 993CRIBInterPro annotationAdd BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 92DisorderedSequence analysisAdd BLAST26
Regioni198 – 234DisorderedSequence analysisAdd BLAST37
Regioni317 – 386DisorderedSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi67 – 83Polar residuesSequence analysisAdd BLAST17
Compositional biasi198 – 233Polar residuesSequence analysisAdd BLAST36
Compositional biasi317 – 363Polar residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M3 family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2090, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B9Q3Z6

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRCSKNM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1370.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000095, CRIB_dom
IPR024077, Neurolysin/TOP_dom2
IPR001567, Pept_M3A_M3B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01432, Peptidase_M3, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50108, CRIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9Q3Z6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHARSGLLLR GVQAAGGRVH HQRSDSLPSV LVMRSRRSLP PRNSLSASVS
60 70 80 90 100
SPPVFFLPRS LCRNNSSGTR SSHSSSLTFH RVPPASSTLE RRTLRRPFAS
110 120 130 140 150
LSRLSHSGQS EWRRQPHGLC SSPPCFSSTF PTPSPPRKPG LFSFLSGLTQ
160 170 180 190 200
ISSRGSRAAG SDELRPGLLQ LPGVHTPEQL VRLGRQAVAD CEAFLATGGA
210 220 230 240 250
PTSSSSGSRE EGKLSSPSSC PSSASSGEAS DVSSSWKEAR RAVQALDAVS
260 270 280 290 300
NTLCKVADGS ELLRQVHPDP RWKQAGAEVV AHVQDFMSRV NVNNKVYDKL
310 320 330 340 350
HRLTEALGDS LSREAQAPSC LSLPSPSTSA SSSPSTSYPS SSPPSSLSSS
360 370 380 390 400
LSASPSSASS EDEGNMAEGD EGVGVSSAQT ENAEKHRLTT EEILVLRSMR
410 420 430 440 450
DAMEQQGVFL EPQVKDRYLR LLTEEATLAA GIAERQETPQ STEGFLVSTD
460 470 480 490 500
VLLASGVPAS LLAQLQGEKR SFFSPRRRPF CRRGGDQVLV AAHSELAHVI
510 520 530 540 550
LRQSADSGLR REVYELQRLP GKDDKETEKQ LLRLLHLRQE LAKLRGYPTW
560 570 580 590 600
TAYAQRDGIL KTPDKINAFL SRLLDALRPG VESDLKTLSV FGASSGLLRD
610 620 630 640 650
AKGLDPWDLP FLLRAYSVRT PDGSTGARSI SIRDLLEGMQ SVVERLLGLR
660 670 680 690 700
FVRAPTAKGE TWHWSVLRYE LHEAPSSRAS RLFSFSPSSS ASPPSSSLDA
710 720 730 740 750
SSSSLRGVLY LDLWARPSKT RLLAQFTVRG SKRLSYAHGQ GWRLGGPLWL
760 770 780 790 800
SAVQRLSREG AASEDEASAT ATVAVEEELR QIPCAALVCS LPPPPEVDMT
810 820 830 840 850
QPTGPDVDRL LEATSLSASL TRSLLHECGH VLHSLLSETE LQHLSGTRGA
860 870 880 890 900
VDFAEFPSNL FEHFSAPLLD GYLASPTGRA RPALGSDGRG KACNFAHLGA
910 920 930 940 950
LQLLLHACVD QAFYSFVPGV SELPPCSGDA LAPSPPPEAV DAQLAALRGC
960 970 980 990 1000
LDTAFSRHHW LAGDPRPGVT EQPICDVVGR PQMARFEHLV HYGGSYFCYL
1010 1020 1030 1040 1050
LCRVMSSFAW QHAFAKDPFD RETGKRLHAI LRRGSIDCSL RPILELAGPG
1060 1070 1080 1090
VLSETQKEQL LNNPHLLPVE PFLEELHADD ASAAAELPFP
Length:1,090
Mass (Da):117,892
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB741D171F333EEED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN714498 Genomic DNA Translation: CEL75156.1
AAYL02000016 Genomic DNA Translation: ESS35952.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ESS35952; ESS35952; TGVEG_272670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN714498 Genomic DNA Translation: CEL75156.1
AAYL02000016 Genomic DNA Translation: ESS35952.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5811.TGME49_072670

PTM databases

SwissPalmiB9Q3Z6

Genome annotation databases

EnsemblProtistsiESS35952; ESS35952; TGVEG_272670

Organism-specific databases

VEuPathDBiToxoDB:TGVEG_272670

Phylogenomic databases

eggNOGiKOG2090, Eukaryota
InParanoidiB9Q3Z6
OMAiVRCSKNM

Family and domain databases

Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR000095, CRIB_dom
IPR024077, Neurolysin/TOP_dom2
IPR001567, Pept_M3A_M3B
PfamiView protein in Pfam
PF01432, Peptidase_M3, 3 hits
PROSITEiView protein in PROSITE
PS50108, CRIB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9Q3Z6_TOXGV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9Q3Z6
Secondary accession number(s): A0A0F7V4U8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 29, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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