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Entry version 66 (26 Feb 2020)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Glycoside hydrolase family 5

Gene

Athe_1859

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CBES521460:G1GUU-1877-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM3 Carbohydrate-Binding Module Family 3
GH44 Glycoside Hydrolase Family 44
GH5 Glycoside Hydrolase Family 5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glycoside hydrolase family 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Athe_1859Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri521460 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007723 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500288932439 – 1294Sequence analysisAdd BLAST1256

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
521460.Athe_1859

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B9MKT9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini355 – 508CBM3InterPro annotationAdd BLAST154
Domaini566 – 719CBM3InterPro annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni323 – 354DisorderedSequence analysisAdd BLAST32
Regioni507 – 565DisorderedSequence analysisAdd BLAST59
Regioni718 – 762DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi332 – 350Pro-richSequence analysisAdd BLAST19
Compositional biasi513 – 559Pro-richSequence analysisAdd BLAST47
Compositional biasi730 – 756Pro-richSequence analysisAdd BLAST27

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105KU2 Bacteria
COG2730 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_262883_0_0_9

KEGG Orthology (KO)

More...
KOi
K01218

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTCKELI

Database of Orthologous Groups

More...
OrthoDBi
6800at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit
2.60.40.710, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR024745 Glyco_hydro_44
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 2 hits
PF00150 Cellulase, 1 hit
PF12891 Glyco_hydro_44, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067 CBM_3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49384 SSF49384, 2 hits
SSF51445 SSF51445, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 2 hits
PS00659 GLYCOSYL_HYDROL_F5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9MKT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVKTKMGKK WLSILCTVVF LLNILFIANV TNLPKVGAAT SNDGVVKIDT
60 70 80 90 100
STLIGTNHAH CWYRDKLETA LRGIRSWGMN SVRVVLSNGY RWTKIPASEV
110 120 130 140 150
ANIISLSRSL GFRAIVLEVH DTTGYGEDGA ACSLAQAVEY WKEIKSVLEG
160 170 180 190 200
NEDFVIINIG NEPYGNNNYQ NWINDTKNAI KALRDAGFKH TIMVDAPNWG
210 220 230 240 250
QDWSNTMRDN AQSIMEADPL RNLVFSIHMY GVYNTASKVE EYIKSFVEKG
260 270 280 290 300
LPLVIGEFGH QHTDGDPDEE AIVRYAKQYK IGLFSWSWCG NSSYVGYLDM
310 320 330 340 350
VNNWDPNNPT PWGQWYKTNA IGASSVPTST PTPTPTATPT ATPTPTPTPS
360 370 380 390 400
STPVAGGQIK VLYANKETNS TTNTIRPWLK VVNTGSSSID LSRVTIRYWY
410 420 430 440 450
TVDGDKAQSA ISDWAQIGAS NVTFKFVKLS SSVSGADYYL EIGFKSGAGQ
460 470 480 490 500
LQAGKDTGEI QIRFNKSDWS NYNQGNDWSW MQSMTSYGEN VKVTAYIDGV
510 520 530 540 550
LVWGQEPSGA TPTPTATPAP TVTPTATPAP TPTPTPTPTA TPTPTPTPTP
560 570 580 590 600
TPTATPTPTP SSTPVAGGQI KVLYANKETN STTNTIRPWL KVVNTGSSSI
610 620 630 640 650
DLSRVTIRYW YTVDGDKAQS AISDWAQIGA SNVTFKFVKL SSSVSGADYY
660 670 680 690 700
LEIGFKSGAG QLQAGKDTGE IQIRFNKSDW SNYNQGNDWS WMQSMTSYGE
710 720 730 740 750
NVKVTAYIDG VLVWGQEPSG ATPTPTATPA PTSTSTPTPT VTPTPTPTPT
760 770 780 790 800
ATPTPTATSI PLPTVSPSSA VIEIAINTNK DRSPISPYIY GANQDIGGVV
810 820 830 840 850
HPARRLGGNR LTGYNWENNF SNAGNDWYHS SDDYLCWSMG ISGEDAKVPA
860 870 880 890 900
AVVSKFHEYS LKNNAYSAIT LQMAGYVSKD NYGTVSENET APSNRWAEVK
910 920 930 940 950
FKKDAPLSLN PDLNDNFVYM DEFINYLINK YGMASSPTGI KGYILDNEPD
960 970 980 990 1000
LWVSTHPRIH PNKVTCKELI DKSVELAKVI KTLDPSAEVF GYASYGFMGY
1010 1020 1030 1040 1050
YSLQDAPDWN QVKGDHRWFI SWYLEQMKKA SDSYGKRLLD VLDLHWYPEA
1060 1070 1080 1090 1100
RGGNIRVCFD GENDTSKEVA IARMQAPRTL WDPTYKTSVK GQITAGENSW
1110 1120 1130 1140 1150
INQWFSDYLP IIPNIKADIE KYYPGTKLAI SEFDYGGRNH ISGGIALADV
1160 1170 1180 1190 1200
LGIFGKYGVY FAARWGDSGS YAAAAYNIYL NYDGKGSKYG NTNVGANTND
1210 1220 1230 1240 1250
VENMPVYASI NGQDDSELHI ILINRNYDRK LPAKISITSS KNYTKAEIYG
1260 1270 1280 1290
FDSNSPTVRK MGSVDNIENN VLTLEVPNLT VFHIVLYSTS VQTK
Length:1,294
Mass (Da):142,178
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD108905CC514BD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001393 Genomic DNA Translation: ACM60947.1

NCBI Reference Sequences

More...
RefSeqi
WP_015908242.1, NC_012034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACM60947; ACM60947; Athe_1859

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31773211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ate:Athe_1859

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001393 Genomic DNA Translation: ACM60947.1
RefSeqiWP_015908242.1, NC_012034.1

3D structure databases

SMRiB9MKT9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi521460.Athe_1859

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
GH44 Glycoside Hydrolase Family 44
GH5 Glycoside Hydrolase Family 5

Genome annotation databases

EnsemblBacteriaiACM60947; ACM60947; Athe_1859
GeneIDi31773211
KEGGiate:Athe_1859

Phylogenomic databases

eggNOGiENOG4105KU2 Bacteria
COG2730 LUCA
HOGENOMiCLU_262883_0_0_9
KOiK01218
OMAiVTCKELI
OrthoDBi6800at2

Enzyme and pathway databases

BioCyciCBES521460:G1GUU-1877-MONOMER

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
2.60.40.710, 2 hits
InterProiView protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR024745 Glyco_hydro_44
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00942 CBM_3, 2 hits
PF00150 Cellulase, 1 hit
PF12891 Glyco_hydro_44, 1 hit
SMARTiView protein in SMART
SM01067 CBM_3, 2 hits
SUPFAMiSSF49384 SSF49384, 2 hits
SSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS51172 CBM3, 2 hits
PS00659 GLYCOSYL_HYDROL_F5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9MKT9_CALBD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9MKT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: February 26, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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