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Entry version 66 (08 May 2019)
Sequence version 1 (24 Mar 2009)
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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotationSAAS annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation
Biological processProtein transportUniRule annotationSAAS annotation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AEBR535289:G1GUT-3591-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotationSAAS annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:Dtpsy_3542Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri535289 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 24HelicalUniRule annotationAdd BLAST18
Transmembranei377 – 397HelicalUniRule annotationAdd BLAST21
Transmembranei440 – 463HelicalUniRule annotationAdd BLAST24
Transmembranei516 – 540HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
535289.Dtpsy_3542

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 366YidC_periplasInterPro annotationAdd BLAST279

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105DHW Bacteria
COG0706 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000101822

KEGG Orthology (KO)

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KOi
K03217

Identification of Orthologs from Complete Genome Data

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OMAi
INPVAGC

Database of Orthologous Groups

More...
OrthoDBi
524437at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.70.98.90, 1 hit

HAMAP database of protein families

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HAMAPi
MF_01810 YidC_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019998 Membr_insert_YidC
IPR028055 Membr_insert_YidC/Oxa1_C
IPR028053 Membr_insert_YidC_N
IPR001708 YidC/ALB3/OXA1/COX18
IPR038210 YidC_periplasmic
IPR038221 YidC_periplasmic_sf

The PANTHER Classification System

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PANTHERi
PTHR12428 PTHR12428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02096 60KD_IMP, 1 hit
PF14849 YidC_periplas, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00701 60KDINNERMP
PR01900 YIDCPROTEIN

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03593 yidC_nterm, 1 hit
TIGR03592 yidC_oxa1_cterm, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9MIZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDIRRTILW VIFGFSMVLL WDKWQIHNGN KATFFPTPPA QTASTPAVAA
60 70 80 90 100
SGAGAADVPV AAASATPGAA PQPPAGASVP PAAIPRERVT VSTDVLRLSF
110 120 130 140 150
DSEGGSLVHG ELLQYPEMED KTKPFLLLDE SASRVYVAQT GLIGNGAGGA
160 170 180 190 200
FPTHKTPMAV VPGPRELQDG QNELTVRFES ADMGGVKLVK TWTLKRGAYD
210 220 230 240 250
VAVKHEVVNT GTAPVSPQLY LQLARDGNKP AGESSFYSTF TGPAVYTEAK
260 270 280 290 300
KYHKVEFKDI ENGKAEIDKS SSNGYVAMVQ HYFATAWLLG DGVQRDNFVR
310 320 330 340 350
KVDTNLYSVG MITPLGEIAP GQSKAVDARL FAGPQIETLL EKLAPGLELV
360 370 380 390 400
KDYGWLTILA KPLYWLLDQL HKVLGNWGWS IVALVFLLKI AFYWLNAKAY
410 420 430 440 450
ASMAKMKAIN PRIMEMRERL KDKPQQMQQE MMRIYREEKV NPMGGCLPIM
460 470 480 490 500
IQIPVFIALY WVLLSSVEMR NAPWIGWIKD LSSPDPFFIL PLLMTLSSLL
510 520 530 540 550
QTALNPAPPD PMQAKMMWLM PLMFSVMFFF FPAGLVLYWL TNNILSIAQQ
560
WIINTRMGVP PQFNLPKFR
Length:569
Mass (Da):63,055
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i754AC4D979A85ADB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM34965.1

NCBI Reference Sequences

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RefSeqi
WP_015914744.1, NC_011992.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACM34965; ACM34965; Dtpsy_3542

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dia:Dtpsy_3542

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM34965.1
RefSeqiWP_015914744.1, NC_011992.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi535289.Dtpsy_3542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM34965; ACM34965; Dtpsy_3542
KEGGidia:Dtpsy_3542

Phylogenomic databases

eggNOGiENOG4105DHW Bacteria
COG0706 LUCA
HOGENOMiHOG000101822
KOiK03217
OMAiINPVAGC
OrthoDBi524437at2

Enzyme and pathway databases

BioCyciAEBR535289:G1GUT-3591-MONOMER

Family and domain databases

Gene3Di2.70.98.90, 1 hit
HAMAPiMF_01810 YidC_type1, 1 hit
InterProiView protein in InterPro
IPR019998 Membr_insert_YidC
IPR028055 Membr_insert_YidC/Oxa1_C
IPR028053 Membr_insert_YidC_N
IPR001708 YidC/ALB3/OXA1/COX18
IPR038210 YidC_periplasmic
IPR038221 YidC_periplasmic_sf
PANTHERiPTHR12428 PTHR12428, 1 hit
PfamiView protein in Pfam
PF02096 60KD_IMP, 1 hit
PF14849 YidC_periplas, 1 hit
PRINTSiPR00701 60KDINNERMP
PR01900 YIDCPROTEIN
TIGRFAMsiTIGR03593 yidC_nterm, 1 hit
TIGR03592 yidC_oxa1_cterm, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9MIZ9_ACIET
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9MIZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 8, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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