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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciAEBR535289:G1GUT-1575-MONOMER
UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:Dtpsy_1552
OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Taxonomic identifieri535289 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000000450 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001177981 – 2623-deoxy-manno-octulosonate cytidylyltransferaseAdd BLAST262

Interactioni

Protein-protein interaction databases

STRINGi535289.Dtpsy_1552

Structurei

3D structure databases

ProteinModelPortaliB9MI81
SMRiB9MI81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OMAiNSGTERC
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

B9MI81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAAPFTVL IPARLASTRL PNKPLADIAG LPMVVHVARR ASQSGAQRCV
60 70 80 90 100
VAADDARIVQ ACQAHGVQAL LTRADHASGS DRLAEACELL GLAGEDIVVN
110 120 130 140 150
VQGDEPLIDP RLIDAVAALL HARGDASMGT AAHAIDSAED FANPNVVKVV
160 170 180 190 200
LDAQGLAHYF SRAPIPHARD HGPGSLWWQP GQTGVPVGFA PLRHIGIYSY
210 220 230 240 250
RAGFLRRFPQ LPAAPTEQLE ALEQLRALWH GHRIAVHVTG SAPGAGVDTP
260
ADLERVRTLL GG
Length:262
Mass (Da):27,666
Last modified:March 24, 2009 - v1
Checksum:iBCCEDE7610C8ADE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM33013.1
RefSeqiWP_015913122.1, NC_011992.1

Genome annotation databases

EnsemblBacteriaiACM33013; ACM33013; Dtpsy_1552
KEGGidia:Dtpsy_1552

Similar proteinsi

Entry informationi

Entry nameiKDSB_ACIET
AccessioniPrimary (citable) accession number: B9MI81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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