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Entry version 68 (12 Aug 2020)
Sequence version 1 (24 Mar 2009)
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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi901ZincUniRule annotation1
Metal bindingi903ZincUniRule annotation1
Metal bindingi912ZincUniRule annotation1
Metal bindingi913ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi102 – 109ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AEBR535289:G1GUT-759-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:Dtpsy_0759
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri535289 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10001842261 – 917Protein translocase subunit SecAAdd BLAST917

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B9MDY4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
535289.Dtpsy_0759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B9MDY4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0653, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005314_3_0_4

KEGG Orthology (KO)

More...
KOi
K03070

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVHYDVQ

Database of Orthologous Groups

More...
OrthoDBi
212453at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01382, SecA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR004027, SEC_C_motif
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30612, PTHR30612, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02810, SEC-C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00906, SECA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00963, secA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9MDY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNFLTKIF GSRNDRLLKQ YRKTVARINA MEPDYEKLSD EALRGKTQEF
60 70 80 90 100
KDRIAQGESL DALLPEAFAV VREGSKRIMK MRHFDVQLVG GMALHYGKIA
110 120 130 140 150
EMRTGEGKTL TATLPVYLNA LSGQGVHVVT VNDYLAGRDA QWMGRLYNFL
160 170 180 190 200
GLTVGINLPQ MPREEKQAAY QADITYGTNN EYGFDYLRDN MVYDARERVQ
210 220 230 240 250
RGLNYAIVDE VDSILIDEAR TPLIISGQAE DHTALYVAMN KVVPLLVRQE
260 270 280 290 300
GEADPRTGEG VTKPGDFTLD EKTHQVFLTE QGHENAERIL ASQGLIPEGA
310 320 330 340 350
SLYDPANITL VHHLYAALRA NHLYHRDQHY VVQNGEIVIV DEFTGRLMAG
360 370 380 390 400
RRWSEGLHQA VEAKEGVNIQ AENQTLASIT FQNYFRLYNK LSGMTGTADT
410 420 430 440 450
EAYEFQEIYG LETVVIPPNR PSKRDDQLDR VYKTTREKYE AAIADIRECH
460 470 480 490 500
ERGQPVLVGT TSIENSEIID ELLNKAGLPH QVLNAKQHAR EADIVAQAGR
510 520 530 540 550
PGMITIATNM AGRGTDIVLG GNVEKAIAAL EADESLSEAE RAARVQELRA
560 570 580 590 600
QWKLDHEKVT ALGGLRIIAT ERHESRRIDN QLRGRSGRQG DPGSSRFYLS
610 620 630 640 650
LDDQLMRIFA GDRVKAIMDR LKMPDGEAIE AGIVTRSIES AQRKVEARNF
660 670 680 690 700
DIRKQLLEYD DVANDQRKVI YQQRNEILDA PDLGVLIDAM RDDCLADVVR
710 720 730 740 750
QYVPAESVEE QWDLAGLEKA LANDWQVSLA LQKEVEGSDA ITDEEILEKV
760 770 780 790 800
QQAAREAFLA KVGQVGAENF TQFERMVLLQ SFDTNWRDHL SALDYLRQGI
810 820 830 840 850
HLRGYAQKQP KQEYKREAFE LFRQLIDQVK NEVTRLMMTV QVQSSAQLDE
860 870 880 890 900
ATQAMEDRGE GISNVTYSSP TETGEVETVA DAATAAQPAA AGVRVGRNDP
910
CPCGSGKKYK QCHGKLA
Length:917
Mass (Da):102,701
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7E6974BA169B131
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM32238.1

NCBI Reference Sequences

More...
RefSeqi
WP_012655743.1, NC_011992.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACM32238; ACM32238; Dtpsy_0759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dia:Dtpsy_0759

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM32238.1
RefSeqiWP_012655743.1, NC_011992.1

3D structure databases

SMRiB9MDY4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi535289.Dtpsy_0759

Proteomic databases

PRIDEiB9MDY4

Genome annotation databases

EnsemblBacteriaiACM32238; ACM32238; Dtpsy_0759
KEGGidia:Dtpsy_0759

Phylogenomic databases

eggNOGiCOG0653, Bacteria
HOGENOMiCLU_005314_3_0_4
KOiK03070
OMAiMVHYDVQ
OrthoDBi212453at2

Enzyme and pathway databases

BioCyciAEBR535289:G1GUT-759-MONOMER

Family and domain databases

HAMAPiMF_01382, SecA, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR004027, SEC_C_motif
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf
PANTHERiPTHR30612, PTHR30612, 1 hit
PfamiView protein in Pfam
PF02810, SEC-C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit
PRINTSiPR00906, SECA
SMARTiView protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit
TIGRFAMsiTIGR00963, secA, 1 hit
PROSITEiView protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECA_ACIET
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9MDY4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: August 12, 2020
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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