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Protein

Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

apgM

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (CTN_0477)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
aPGAMUniRule annotation
Gene namesi
Name:apgMUniRule annotation
Ordered Locus Names:CTN_0964
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000000445 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001845751 – 401Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi309803.CTN_0964

Structurei

3D structure databases

ProteinModelPortaliB9K857
SMRiB9K857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E3H Bacteria
COG3635 LUCA
HOGENOMiHOG000004785
KOiK15635
OMAiGDIAFRC
OrthoDBiPOG091H0Q39

Family and domain databases

CDDicd16011 iPGM_like, 1 hit
Gene3Di3.40.720.10, 2 hits
HAMAPiMF_01402_B ApgM_B, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR023665 ApgAM_prokaryotes
IPR006124 Metalloenzyme
IPR004456 Pglycerate_mutase_ApgM
PANTHERiPTHR31209 PTHR31209, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PF10143 PhosphMutase, 1 hit
PIRSFiPIRSF006392 IPGAM_arch, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
TIGRFAMsiTIGR00306 apgM, 1 hit

Sequencei

Sequence statusi: Complete.

B9K857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDKQKFVSK LVTTNDTKIV LLVMDGLGDI PVNGKTPLQA ASTPNLDSLA
60 70 80 90 100
KESDLGQTVP VLPGITPGSG PGHLSLFGYD PIKYQIGRGI LEALGIGVEV
110 120 130 140 150
GEKDVVARAN FATWDGNVVL DRRAGRPATE ESAKVVQLLS EKIKKIEDVE
160 170 180 190 200
ITFYPGKEHR FVVKFTGEGL GDRVTDADPQ KEGHPMVWAE GLDEPSKKTA
210 220 230 240 250
RIANELIRKI AEVLKDNPKI NFALIRGFSK YPDLPKFPEI YKLRAGAIAT
260 270 280 290 300
YPMYRGLAKL VGMEIIETGQ TVEDEINTLK EKWNDFDFFY VHVKKTDSYG
310 320 330 340 350
EDGKFDEKVK VIEEVDRVIP EILALKPDVL VITGDHSTPV PLKAHSWHPV
360 370 380 390 400
PLLIWSRYTR RGLSQAFNEF ECARGTLGTI HASDVMTLAL AYAGRLEKFG

A
Length:401
Mass (Da):44,338
Last modified:March 24, 2009 - v1
Checksum:iF7AE56316305A861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA Translation: ACM23140.1
RefSeqiWP_015919457.1, NC_011978.1

Genome annotation databases

EnsemblBacteriaiACM23140; ACM23140; CTN_0964
KEGGitna:CTN_0964

Entry informationi

Entry nameiAPGM_THENN
AccessioniPrimary (citable) accession number: B9K857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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