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UniProtKB - B9K7T2 (B9K7T2_THENN)
Protein
DNA polymerase I
Gene
polA
Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)
Status
Functioni
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
UniRule annotationCatalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)UniRule annotationARBA annotationEC:2.7.7.7UniRule annotationARBA annotation
GO - Molecular functioni
- 3'-5' exonuclease activity Source: InterPro
- DNA binding Source: UniProtKB-UniRule
- DNA-directed DNA polymerase activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA-dependent DNA replication Source: UniProtKB-UniRule
- DNA repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Hydrolase, NucleaseARBA annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repairUniRule annotation, DNA replicationUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase IUniRule annotationARBA annotation (EC:2.7.7.7UniRule annotationARBA annotation) |
Gene namesi | Name:polAUniRule annotation Ordered Locus Names:CTN_0839Imported |
Organismi | Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)Imported |
Taxonomic identifieri | 309803 [NCBI] |
Taxonomic lineagei | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 264 | 53EXOcInterPro annotationAdd BLAST | 263 | |
Domaini | 298 – 484 | 3'-5' exonucleaseInterPro annotationAdd BLAST | 187 | |
Domaini | 653 – 860 | POLAcInterPro annotationAdd BLAST | 208 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 630 – 651 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 630 – 649 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0258, Bacteria COG0749, Bacteria |
HOGENOMi | CLU_004675_0_0_0 |
OMAi | NRPPMPD |
Family and domain databases
CDDi | cd09898, H3TH_53EXO, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR020046, 5-3_exonucl_a-hlix_arch_N IPR002421, 5-3_exonuclease IPR036279, 5-3_exonuclease_C_sf IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR020045, DNA_polI_H3TH IPR018320, DNA_polymerase_1 IPR002298, DNA_polymerase_A IPR008918, HhH2 IPR029060, PIN-like_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 1 hit |
Pfami | View protein in Pfam PF01367, 5_3_exonuc, 1 hit PF02739, 5_3_exonuc_N, 1 hit PF00476, DNA_pol_A, 1 hit PF01612, DNA_pol_A_exo1, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00475, 53EXOc, 1 hit SM00279, HhH2, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF47807, SSF47807, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit SSF88723, SSF88723, 1 hit |
TIGRFAMsi | TIGR00593, pola, 1 hit |
i Sequence
Sequence statusi: Complete.
B9K7T2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARLFLFDGT ALAYRAYYAL DRSLSTSTGI PTNAVYGVAR MLVKFIKEHI
60 70 80 90 100
IPEKDYAAVA FDKKAATFRH KLLEAYKAQR PKTPDLLVQQ LPYIKRLIEA
110 120 130 140 150
LGFKVLELEG YEADDIIATL AVKGCTFFDE IFIITGDKDM LQLVNEKIKV
160 170 180 190 200
WRIVKGISDL ELYDSKKVKE RYGVEPHQIP DLLALTGDEI DNIPGVTGIG
210 220 230 240 250
EKTAVQLLGK YRNLEDILEH ARELPQRVRK ALLRDREVAI LSKKLATLVT
260 270 280 290 300
NAPVEVDWEE MKYRGYDKRK LLPILKELEF ASIMKELQLY EEAEPTGYEI
310 320 330 340 350
VKDHKTFEDL IEKLKEVPSF ALDLETSSLD PFNCEIVGIS VSFKPKTAYY
360 370 380 390 400
IPLHHRNAQN LDETLVLSKL KEILEDPSSK IVGQNLKYDY KVLMVKGISP
410 420 430 440 450
VYPHFDTMIA AYLLEPNEKK FNLEDLSLKF LGYKMTSYQE LMSFSSPLFG
460 470 480 490 500
FSFADVPVDK AANYSCEDAD ITYRLYKILS MKLHEAELEN VFYRIEMPLV
510 520 530 540 550
NVLARMELNG VYVDTEFLKK LSEEYGKKLE ELAEKIYQIA GEPFNINSPK
560 570 580 590 600
QVSKILFEKL GIKPRGKTTK TGEYSTRIEV LEEIANEHEI VPLILEYRKI
610 620 630 640 650
QKLKSTYIDT LPKLVNPKTG RIHASFHQTG TATGRLSSSD PNLQNLPTKS
660 670 680 690 700
EEGKEIRKAI VPQDPDWWIV SADYSQIELR ILAHLSGDEN LVKAFEEGID
710 720 730 740 750
VHTLTASRIY NVKPEEVNEE MRRVGKMVNF SIIYGVTPYG LSVRLGIPVK
760 770 780 790 800
EAEKMIISYF TLYPKVRSYI QQVVAEAKEK GYVRTLFGRK RDIPQLMARD
810 820 830 840 850
KNTQSEGERI AINTPIQGTA ADIIKLAMID IDEELRKRNM KSRMIIQVHD
860 870 880 890
ELVFEVPDEE KEELVDLVKN KMTNVVKLSV PLEVDISIGK SWS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000916 Genomic DNA Translation: ACM23015.1 |
RefSeqi | WP_015919332.1, NC_011978.1 |
Genome annotation databases
EnsemblBacteriai | ACM23015; ACM23015; CTN_0839 |
KEGGi | tna:CTN_0839 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000916 Genomic DNA Translation: ACM23015.1 |
RefSeqi | WP_015919332.1, NC_011978.1 |
3D structure databases
SMRi | B9K7T2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 309803.CTN_0839 |
Genome annotation databases
EnsemblBacteriai | ACM23015; ACM23015; CTN_0839 |
KEGGi | tna:CTN_0839 |
Phylogenomic databases
eggNOGi | COG0258, Bacteria COG0749, Bacteria |
HOGENOMi | CLU_004675_0_0_0 |
OMAi | NRPPMPD |
Family and domain databases
CDDi | cd09898, H3TH_53EXO, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR020046, 5-3_exonucl_a-hlix_arch_N IPR002421, 5-3_exonuclease IPR036279, 5-3_exonuclease_C_sf IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR020045, DNA_polI_H3TH IPR018320, DNA_polymerase_1 IPR002298, DNA_polymerase_A IPR008918, HhH2 IPR029060, PIN-like_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 1 hit |
Pfami | View protein in Pfam PF01367, 5_3_exonuc, 1 hit PF02739, 5_3_exonuc_N, 1 hit PF00476, DNA_pol_A, 1 hit PF01612, DNA_pol_A_exo1, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00475, 53EXOc, 1 hit SM00279, HhH2, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF47807, SSF47807, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit SSF88723, SSF88723, 1 hit |
TIGRFAMsi | TIGR00593, pola, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B9K7T2_THENN | |
Accessioni | B9K7T2Primary (citable) accession number: B9K7T2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 24, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |