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Entry version 59 (02 Jun 2021)
Sequence version 1 (24 Mar 2009)
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Protein

Cellobiose phosphorylase

Gene

cbpA

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorolysis of cellobiose, yielding glucose 1-phosphate and glucose. Is inactive against cellotriose and the disaccharides lactose, chitobiose and xylobiose. May be the primary enzyme for processing cellobiose in T.neapolitana.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 26.3 sec(-1).1 Publication
  1. KM=1.42 mM for cellobiose1 Publication

    pH dependencei

    Optimum pH is 4.5 to 6.0.1 Publication

    Temperature dependencei

    Optimum temperature is 85 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cellulose degradation

    This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

    Pathwayi: beta-D-glucan degradation

    This protein is involved in the pathway beta-D-glucan degradation, which is part of Glycan metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway beta-D-glucan degradation and in Glycan metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei481NucleophileBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    TNEA309803:G1GAR-778-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.20, 6332

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    B9K7M6

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00350
    UPA00696

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GH94, Glycoside Hydrolase Family 94

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cellobiose phosphorylase1 Publication (EC:2.4.1.201 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:cbpA1 Publication
    Ordered Locus Names:CTN_0783
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri309803 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000445 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004314431 – 813Cellobiose phosphorylaseAdd BLAST813

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    309803.CTN_0783

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    B9K7M6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyl hydrolase 94 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG3459, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_019054_0_0_0

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YVYAQMI

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd11754, GH94N_CBP_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.50.10.10, 1 hit
    2.70.98.40, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR008928, 6-hairpin_glycosidase_sf
    IPR012341, 6hp_glycosidase-like_sf
    IPR009342, Carb-bd_put_dom
    IPR011013, Gal_mutarotase_sf_dom
    IPR033432, GH36_catalytic
    IPR037825, GH94N_CBP
    IPR037018, Glyco_hydro_65_N_sf
    IPR010383, Glyco_hydrolase_94

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17167, Glyco_hydro_36, 1 hit
    PF06165, Glyco_transf_36, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01068, CBM_X, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48208, SSF48208, 1 hit
    SSF74650, SSF74650, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    B9K7M6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKFGYFDDKN REYVIVTPRT PYPWINYLGT EDFFSIISHM AGGYCFYKDA
    60 70 80 90 100
    RLRRITRFRY NNVPTDAGGR YFYIREEDGD FWSPTWMPVR RDLSFFEARH
    110 120 130 140 150
    GLGYTKIAGE RNGLRATITF FVPRHFTGEV HHLVLQNRTE RPRRIKLFSF
    160 170 180 190 200
    IEFCLWNALD DMTNFQRNYS TGEVEIEGSV IYHKTEYRER RNHYAFYSVN
    210 220 230 240 250
    HSIDGFDTDR ESFMGLYNGF EAPQAVVEGN PRNSVASGWA PIASHYLELE
    260 270 280 290 300
    IPPLGEKELI FILGYVENPE EEKWERPGVI NKKRAKEMIE RFKTGEDVER
    310 320 330 340 350
    ALKELKEYWD ELLGRIQVET HDEKLNRMVN IWNQYQCMVT FNIARSASYF
    360 370 380 390 400
    ESGISRGIGF RDSNQDILGF VHMIPEKARQ RILDLASIQF EDGSTYHQFQ
    410 420 430 440 450
    PLTKKGNNEI GGGFNDDPLW LILSTSAYIK ETGDWSILNE EVPFDNDPDK
    460 470 480 490 500
    KATLFEHLKR SFYFTVNNLG PHGLPLIGRA DWNDCLNLNC FSKNPDESFQ
    510 520 530 540 550
    TTVNALDGRV AESVFIAGLF VLAGKEFVEI CRRLGLEDEA KEAEKHVKKM
    560 570 580 590 600
    IETTLEYGWD GEWFLRAYDA FGRKVGSKEC EEGKIFIEPQ GMCVMAGIGV
    610 620 630 640 650
    ENGYAKKALD SVKEHLDTPY GLVLQQPAYS RYYIELGEIS SYPPGYKENA
    660 670 680 690 700
    GIFCHNNPWV AIAETVIGRG DRAFEIYRKI TPAYLEDISE IHRTEPYVYA
    710 720 730 740 750
    QMVAGKDAPR HGEAKNSWLT GTAAWSFVAI TQYILGVRPT YDGLMVDPCI
    760 770 780 790 800
    PEDWDGFKIT RRFRGATYEI TVKNPHHVSK GVKEIIVDGK KIEGQVLPVF
    810
    NDGKVHRVEV LMG
    Length:813
    Mass (Da):93,679
    Last modified:March 24, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D6AE176E4C0D659
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182Y → F in AAB95491 (PubMed:10960102).1
    Sequence conflicti197Y → F in AAB95491 (PubMed:10960102).1
    Sequence conflicti328Missing in AAB95491 (PubMed:10960102).1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF039487 Genomic DNA Translation: AAB95491.2
    CP000916 Genomic DNA Translation: ACM22959.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_015919276.1, NC_011978.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ACM22959; ACM22959; CTN_0783

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    tna:CTN_0783

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF039487 Genomic DNA Translation: AAB95491.2
    CP000916 Genomic DNA Translation: ACM22959.1
    RefSeqiWP_015919276.1, NC_011978.1

    3D structure databases

    SMRiB9K7M6
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi309803.CTN_0783

    Protein family/group databases

    CAZyiGH94, Glycoside Hydrolase Family 94

    Genome annotation databases

    EnsemblBacteriaiACM22959; ACM22959; CTN_0783
    KEGGitna:CTN_0783

    Phylogenomic databases

    eggNOGiCOG3459, Bacteria
    HOGENOMiCLU_019054_0_0_0
    OMAiYVYAQMI

    Enzyme and pathway databases

    UniPathwayiUPA00350
    UPA00696
    BioCyciTNEA309803:G1GAR-778-MONOMER
    BRENDAi2.4.1.20, 6332
    SABIO-RKiB9K7M6

    Family and domain databases

    CDDicd11754, GH94N_CBP_like, 1 hit
    Gene3Di1.50.10.10, 1 hit
    2.70.98.40, 1 hit
    InterProiView protein in InterPro
    IPR008928, 6-hairpin_glycosidase_sf
    IPR012341, 6hp_glycosidase-like_sf
    IPR009342, Carb-bd_put_dom
    IPR011013, Gal_mutarotase_sf_dom
    IPR033432, GH36_catalytic
    IPR037825, GH94N_CBP
    IPR037018, Glyco_hydro_65_N_sf
    IPR010383, Glyco_hydrolase_94
    PfamiView protein in Pfam
    PF17167, Glyco_hydro_36, 1 hit
    PF06165, Glyco_transf_36, 1 hit
    SMARTiView protein in SMART
    SM01068, CBM_X, 1 hit
    SUPFAMiSSF48208, SSF48208, 1 hit
    SSF74650, SSF74650, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPA_THENN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9K7M6
    Secondary accession number(s): O52504
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 7, 2015
    Last sequence update: March 24, 2009
    Last modified: June 2, 2021
    This is version 59 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families
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