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Protein

Biotin carboxylase

Gene

accC

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.UniRule annotation
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (accC), Biotin carboxylase (accC)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingPROSITE-ProRule annotation, BiotinUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylaseUniRule annotation (EC:6.3.4.14UniRule annotation, EC:6.4.1.2UniRule annotation)
Gene namesi
Name:accCImported
Ordered Locus Names:Avi_7655Imported
Encoded oniPlasmid pAtS4eImported
OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))Imported
Taxonomic identifieri311402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
Proteomesi
  • UP000001596 Componenti: Plasmid pAtS4e

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB9K5U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 452Biotin carboxylationInterPro annotationAdd BLAST445
Domaini127 – 324ATP-graspInterPro annotationAdd BLAST198

Phylogenomic databases

HOGENOMiHOG000008988
KOiK01961
OMAiVWLGHRD
OrthoDBiPOG091H02XZ

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR004549 Acetyl_CoA_COase_biotin_COase
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00514 accC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9K5U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSDTKRPFD TVLIANRGEI ALRIQRACRE LGLRTVMICS EADRDAPYGA
60 70 80 90 100
TGDEFICIGP SAPGRSYFNQ SAILLAMRAS GAGAVHPGYG FLSENADFAE
110 120 130 140 150
AVEQAGLTFI GPPASAIRIM GDKIAAKRAM IEAGVPCVPG PDTALGEDMA
160 170 180 190 200
DIAEIAAKIG YPVIIKAAGG GGGRGMRIVR DAAALADAVS ITREEARRAF
210 220 230 240 250
GNPELYMEKF LEKPRHVEIQ VLCDNFGNAV WLGHRDCSMQ RRHQKVVEEA
260 270 280 290 300
PSPGIPADVA ATVGARCVAA CQRIGYRGVG TFEFLYENGE FYFIEMNTRL
310 320 330 340 350
QVEHPVTEMT SGLDIVCEQL RVALGLPMML TQADIQTNGH SFECRINAED
360 370 380 390 400
PYTFAGSPGK ITALQLPSGE GVRVDTHVVE GYTVPAHYDS LIAKLIVHAP
410 420 430 440 450
TRDEAIVRMR AALDALKIDG ITTNIALHKA IFEDAGFCAG GADIHHLEKW

LSKRSAA
Length:457
Mass (Da):49,142
Last modified:March 24, 2009 - v1
Checksum:iFD6FD5CCA34719BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000638 Genomic DNA Translation: ACM40239.1
RefSeqiWP_015918681.1, NC_011981.1

Genome annotation databases

EnsemblBacteriaiACM40239; ACM40239; Avi_7655
GeneIDi31499193
KEGGiavi:Avi_7655

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000638 Genomic DNA Translation: ACM40239.1
RefSeqiWP_015918681.1, NC_011981.1

3D structure databases

ProteinModelPortaliB9K5U1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM40239; ACM40239; Avi_7655
GeneIDi31499193
KEGGiavi:Avi_7655

Phylogenomic databases

HOGENOMiHOG000008988
KOiK01961
OMAiVWLGHRD
OrthoDBiPOG091H02XZ

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR004549 Acetyl_CoA_COase_biotin_COase
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00514 accC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB9K5U1_AGRVS
AccessioniPrimary (citable) accession number: B9K5U1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, PlasmidImported, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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