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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei603For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:Arad_2357Imported
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)Imported
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000001600 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi311403.Arad_2357

Structurei

3D structure databases

ProteinModelPortaliB9JF81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2InterPro annotationAdd BLAST216
Domaini283 – 422SISInterPro annotationAdd BLAST140
Domaini456 – 598SISInterPro annotationAdd BLAST143

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B9JF81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGIVGT KPVAGRLVDA LRRLEYRGYD SAGVATIHDG VMDRRRAEGK
60 70 80 90 100
LFNLEKRLDA EPLPGVTGIA HTRWATHGVP NETNAHPHFV EGVAVVHNGI
110 120 130 140 150
IENFSELREE LKAEGKVFTT QTDTEVVAHL LAKYVGEGLD PRAAMLKMLN
160 170 180 190 200
RVTGAYALAI MFQSDPDTLM AARSGPPLAV GFGNGEMFLG SDAIALSPFT
210 220 230 240 250
NEITYLVDGD CAIITRNSAT ILDFNGQEVS RPRQISQATA YVVDKGNHRH
260 270 280 290 300
FMEKEIYEQP EVISHALSQY VDFVGHRLRP NASAIDFKGV SGLAISACGT
310 320 330 340 350
AYLAGLIGKY WFERYARLPV EIDVASEFRY REMPLSPSQA ALFISQSGET
360 370 380 390 400
ADTLASLRYC KDNGLKIGAI VNVKESTIAR ESDAVFPIMA GPEIGVASTK
410 420 430 440 450
AFTCQLAVLA SLAIGAGVAR GTVSAEDENA MVRHLVEMPR IMARVLNIIQ
460 470 480 490 500
PQMETLAREI SKFKDVLYLG RGTSFPLAME GALKLKEISY IHAEGYAAGE
510 520 530 540 550
LKHGPIALID ENMPVIVIAP YDRFFDKTVS NMQEVAARGG RIIFITDEAG
560 570 580 590 600
AAASTLPTMA TIVLPVVDEI IAPMIFSLPI QLLAYHTAVF MGTDVDQPRN

LAKSVTVE
Length:608
Mass (Da):65,925
Last modified:March 24, 2009 - v1
Checksum:iAC2C0E8C397B671A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA Translation: ACM26571.1
RefSeqiWP_012651445.1, NC_011985.1

Genome annotation databases

EnsemblBacteriaiACM26571; ACM26571; Arad_2357
KEGGiara:Arad_2357

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000628 Genomic DNA Translation: ACM26571.1
RefSeqiWP_012651445.1, NC_011985.1

3D structure databases

ProteinModelPortaliB9JF81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi311403.Arad_2357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM26571; ACM26571; Arad_2357
KEGGiara:Arad_2357

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB9JF81_AGRRK
AccessioniPrimary (citable) accession number: B9JF81
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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