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Protein

Histidinol dehydrogenase, chloroplastic

Gene

POPTR_001G465300v3

Organism
Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (POPTR_004G090500v3), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (POPTR_017G124800v3), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (POPTR_017G124800v3)
  5. Imidazole glycerol phosphate synthase hisHF (POPTR_001G267400v3), Imidazole glycerol phosphate synthase hisHF (POPTR_001G267400v3), Imidazole glycerol phosphate synthase hisHF (POPTR_009G061700v3), Imidazole glycerol phosphate synthase hisHF (POPTR_001G267400v3), Imidazole glycerol phosphate synthase hisHF (POPTR_009G061700v3)
  6. Imidazoleglycerol-phosphate dehydratase (POPTR_010G087600v3), Imidazoleglycerol-phosphate dehydratase (POPTR_010G087600v3), Imidazoleglycerol-phosphate dehydratase (POPTR_010G087600v3)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase, chloroplastic (POPTR_011G163400v3), Histidinol dehydrogenase, chloroplastic (POPTR_001G465300v3)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127NADUniRule annotation1
Binding sitei189NADUniRule annotation1
Binding sitei212NADUniRule annotation1
Binding sitei238SubstrateUniRule annotation1
Metal bindingi260ZincUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Metal bindingi263ZincUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei328Proton acceptorUniRule annotation1
Active sitei329Proton acceptorUniRule annotation1
Binding sitei329SubstrateUniRule annotation1
Metal bindingi362ZincUniRule annotation1
Binding sitei362SubstrateUniRule annotation1
Binding sitei416SubstrateUniRule annotation1
Metal bindingi421ZincUniRule annotation1
Binding sitei421SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplasticUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
ORF Names:POPTR_001G465300v3Imported
OrganismiPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)Imported
Taxonomic identifieri3694 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus
Proteomesi
  • UP000006729 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChloroplastUniRule annotation, Plastid

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00013

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

B9GH07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAMKSYRLS ELNNSEVESL KARPRIDFSS IFGIVNPIVD DVRQRGDAAV
60 70 80 90 100
KDYTSRFDKV KLDKIVENVS ELPDPELDAT VKEAFDVAYN NIYAFHLAQK
110 120 130 140 150
SVEKSVETMK GVRCKRVARS ISSVGLYVPG GTAVLPSTAL MLAIPAQIAG
160 170 180 190 200
CKTVVLATPP AQDGSICKEV LYCAKKAGVT HILKAGGAQA ISAMAWGTES
210 220 230 240 250
CPKAEKIFGP GNQYVTAAKM ILQNSEAMIS IDMPAGPSEV LVIADRYASP
260 270 280 290 300
VHIAADLLSQ AEHGPDSQVV LVVAGDGVDM KAIEEEISKQ CQSLPRGEYA
310 320 330 340 350
SKALSHSFTV FARDMVEAVS FSNLYAPEHL IINVKEAEKW ESFIENAGSV
360 370 380 390 400
FLGPWTPESV GDYASGTNHV LPTYGYARMY GGVSLDSFQK YMTVQSLTEE
410 420 430 440
GLRKLGPYVA TMAEVEGLDA HKRAVTLRLQ DIEARQVSNT R
Length:441
Mass (Da):47,768
Last modified:March 24, 2009 - v1
Checksum:iE10AFE0C50A7EAF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM009290 Genomic DNA Translation: PNT60305.1
RefSeqiXP_002300563.1, XM_002300527.2

Genome annotation databases

EnsemblPlantsiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960
GeneIDi7480422
GrameneiPOPTR_0001s46960.1; POPTR_0001s46960.1; POPTR_0001s46960
KEGGipop:7480422

Similar proteinsi

Entry informationi

Entry nameiB9GH07_POPTR
AccessioniPrimary (citable) accession number: B9GH07
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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