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Protein

Receptor-type tyrosine-protein phosphatase zeta

Gene

Ptprz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1898SubstrateBy similarity1
Active sitei1930Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1974SubstrateBy similarity1
Sitei2220Ancestral active siteBy similarity1

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI
  • phosphatase activity Source: MGI
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase zeta (EC:3.1.3.481 Publication)
Short name:
R-PTP-zeta
Gene namesi
Name:Ptprz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97816 Ptprz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1637ExtracellularSequence analysisAdd BLAST1613
Transmembranei1638 – 1658HelicalSequence analysisAdd BLAST21
Topological domaini1659 – 2312CytoplasmicSequence analysisAdd BLAST654

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian rate, are viable and fertile (PubMed:11003666). Embryonic mutant mice show increased levels of oligodendrocyte precursor cells in the spinal cord, combined with impaired differentiation of the precursor cells into mature, fully myelinating oligodendrocytes (PubMed:21969550). Mutant mice show slightly increased susceptibility to experimental autoimmune encephalomyelitis (EAE) and strongly reduced recovery. Contrary to wild-type, mutant mice remain paralyzed and display increased levels of apoptotic oligodendrocytes in the spinal cord (PubMed:12355066). Besides, mutant mice display impaired contextual fear memory, probably due to impaired dephosphorylation of proteins that are part of important signaling cascades (PubMed:16513268).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000042488225 – 2312Receptor-type tyrosine-protein phosphatase zetaAdd BLAST2288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 240By similarity
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 264By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei572PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei645PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1058N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1559N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1681PhosphothreonineCombined sources1
Modified residuei1684PhosphothreonineCombined sources1
Modified residuei2052PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiB9EKR1
PaxDbiB9EKR1
PeptideAtlasiB9EKR1
PRIDEiB9EKR1

PTM databases

iPTMnetiB9EKR1
PhosphoSitePlusiB9EKR1

Expressioni

Tissue specificityi

Detected in neurons and astrocytes in the central nervous system (CNS). Detected in the hippocampus and in brain cortex.2 Publications

Gene expression databases

BgeeiENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiB9EKR1 baseline and differential
GenevisibleiB9EKR1 MM

Interactioni

Subunit structurei

The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774, PubMed:21969550). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202509, 1 interactor
IntActiB9EKR1, 1 interactor
STRINGi10090.ENSMUSP00000088056

Structurei

3D structure databases

ProteinModelPortaliB9EKR1
SMRiB9EKR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 300Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST265
Domaini314 – 413Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini1714 – 1989Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST276
Domaini2020 – 2279Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1930 – 1936Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi951 – 954Poly-Ser4
Compositional biasi1225 – 1230Poly-Ser6
Compositional biasi1426 – 1439Poly-AspAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000090262
HOVERGENiHBG053760
InParanoidiB9EKR1
KOiK08114
OrthoDBiEOG091G018S
PhylomeDBiB9EKR1
TreeFamiTF351978

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B9EKR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILQSFLAC VQLLCLCRLD WAYGYYRQQR KLVEEIGWSY TGALNQKNWG
60 70 80 90 100
KKYPICNSPK QSPINIDEDL TQVNVNLKKL KFQGWEKASL ENTFIHNTGK
110 120 130 140 150
TVEINLTNDY YLSGGLSEKV FKASKITFHW GKCNVSSEGS EHSLEGQKFP
160 170 180 190 200
LEMQVYCFDA DRFSSFEEAV KGKGRLRALS ILFEVGVEEN LDYKAIIDGT
210 220 230 240 250
ESVSRFGKQA ALDPFVLQNL LPNSTDKYYI YNGSLTSPPC TDTVEWIVFK
260 270 280 290 300
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY
310 320 330 340 350
TGKEEIHEVV CSSEPENVQA DPENYTSLLV TWERPRVVYD AMIEKFAVLY
360 370 380 390 400
QPLAGNDQAK HEFLTDGYQD LGAILNNLLP NMSYVLQIVA VCSNGLYGKY
410 420 430 440 450
SDQLIVDMPT EDAELDLFPE LIGTEEIIKE EEYGKDNEED TGLNPGRDSV
460 470 480 490 500
TNQIRKKEPQ VSTTTHYNHM GTKYNEAKTN RSPTRGSEFS GKSDVPNTSP
510 520 530 540 550
NSTSQHVAEF ETERGISLPS QTGTNLPPHN VEGTSASLNS GSKTLFIFPQ
560 570 580 590 600
MNLSGTAESL NTVPITEYKE VSADVSEEEN FLTDFKLDTG ADDSSGSSPS
610 620 630 640 650
TSTVPFSSDN LSHGYITSSD MPEAITYDVL KPGSTRNAPE DSAPSGSEES
660 670 680 690 700
LKDPSLEGSV WFPGSTDLTT QSETGSGRES FLQVNSTDIQ IDESRETTES
710 720 730 740 750
FSPDATVSQD PSVTDMGMPH YSTFAYLPTE VTPQAFTPSS RPLDLAPTIN
760 770 780 790 800
ILHSQTTQPV YNGETPLQPS YSSEVFPLAT PLLLDNQTLN TTPAASSSDS
810 820 830 840 850
ALHATPVSPS VGVSFESILS SYDDAPLLPF SSASFSSEMF RHLHTVSQTL
860 870 880 890 900
PQVTSAAERD ELSLHASLLV ARGDLLLEPS LVQYSDVASH QATTRAASDT
910 920 930 940 950
LGFGSESAVF YKTSMVSQIE SPRSDVVMHA YSSGPEPSYT VEGSHHVPTV
960 970 980 990 1000
SYSSAMPLHG SVDVSDQGSL LINPSHISMP ESSFITPTAS LLQPPPALSG
1010 1020 1030 1040 1050
DGEWSGASSD SELLLPDADG LRTLNISSPV SVAEFTYTTS VFADGIKPLS
1060 1070 1080 1090 1100
KSEMMYGNET ELKMSSFSDM AYPSKSTVVP KMSDVVHKWS ESLKETSVSI
1110 1120 1130 1140 1150
SSMKSVFPES LVYPTTKGFE QGVSHVPEII FPVQPTHTAS QASGDTWLKP
1160 1170 1180 1190 1200
GLSANSEAAF SDTASREVVH PSTQPLLYEA ATPFNTEALL QPSFQASDVD
1210 1220 1230 1240 1250
TLLKTALPSV PSDPILAGTP QVEQSSSSVS HPMASESGSS ESMLHFTSVP
1260 1270 1280 1290 1300
ILDISPSKVH STPLQGLTVP HSSKKFSEQG LLKSKSPQQV LPSLFSNDEF
1310 1320 1330 1340 1350
FQSAHLDVSQ AYPPKGRHAF VTPVLSIDEP QNTLINKLVY SEDIFSSTEI
1360 1370 1380 1390 1400
SITDKVLTGL PTLASDVLSS TDHSVPLGSG PISLTMVSPN RDDSVTTAKL
1410 1420 1430 1440 1450
LLPSTATSKL TQSARSDADL VGGGEDGDDY DDDDYDDIDR GRFPVNKCMS
1460 1470 1480 1490 1500
CLPYRESREK VMNDSDTQES SLVDQSDPIS PLLFENTEEE NGGTGVTRVD
1510 1520 1530 1540 1550
KSPPPSMLPQ NHNDGKEDSD IQMGSAVLPH TPGSKAWAVL TSDEESGSGQ
1560 1570 1580 1590 1600
GTSDSLNDNE TSTDFSFPDV NEKDTDGVLE TDDTGIAPGS PRSSTPSVTS
1610 1620 1630 1640 1650
GHSGVSNSSE AEASNSSHES RIGLAEGLES EKKAVIPLVI VSALTFICLV
1660 1670 1680 1690 1700
VLVGILIYWR KCFQTAHFYL EDNTSPRVIS TPPTPIFPIS DDIGAIPIKH
1710 1720 1730 1740 1750
FPKHVADLHA SNGFTEEFET LKEFYQEVQS CTADLGITAD SSNHPDNKHK
1760 1770 1780 1790 1800
NRYVNIVAYD HSRVKLTQLA EKDGKLTDYI NANYVDGYNR PKAYIAAQGP
1810 1820 1830 1840 1850
LKSTAEDFWR MIWEHNVEVI VMITNLVEKG RRKCDQYWPT DGSEEYGSFL
1860 1870 1880 1890 1900
VNQKSVQVLA YYTVRNFTLR NTKLKKGSQK GRSSGRLVTQ YHYTQWPDMG
1910 1920 1930 1940 1950
VPEYSLPVLA FVRKAAQAKR HAVGPVVVHC SAGVGRTGTY IVLDSMLQQI
1960 1970 1980 1990 2000
QHEGTVNIFG FLKHIRSQRN YLVQTEEQYV FIHDTLVEAI LSKETEVPDS
2010 2020 2030 2040 2050
HIHSYVNTLL IPGPTGKTKL EKQFQLLSQS NILQSDYSTA LKQCNREKNR
2060 2070 2080 2090 2100
TSSIIPVERS RVGISSLSGE GTDYINASYI MGYYQSNEFI ITQHPLLHTI
2110 2120 2130 2140 2150
KDFWRMIWDH NAQLVVMIPD GQNMAEDEFV YWPNKDEPIN CESFKVTLMS
2160 2170 2180 2190 2200
EEHKCLSNEE KLIVQDFILE ATQDDYVLEV RHFQCPKWPN PDSPISKTFE
2210 2220 2230 2240 2250
LISIIKEEAA NRDGPMIVHD EHGGVTAGTF CALTTLMHQL EKENAMDVYQ
2260 2270 2280 2290 2300
VAKMINLMRP GVFTDIEQYQ FLYKVVLSLV STRQEENPST SLDSNGAALP
2310
DGNIAESLES LV
Length:2,312
Mass (Da):254,405
Last modified:March 24, 2009 - v1
Checksum:i91C5D58F74BA999C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RXS8B2RXS8_MOUSE
Ptprz1 protein
Ptprz1
1,463Annotation score:
A0A0J9YVD2A0A0J9YVD2_MOUSE
Receptor-type tyrosine-protein phos...
Ptprz1
1,612Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.
BC151071 mRNA Translation: AAI51072.1
CCDSiCCDS39437.1
RefSeqiNP_001074775.1, NM_001081306.1
UniGeneiMm.41639

Genome annotation databases

EnsembliENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748
GeneIDi19283
KEGGimmu:19283
UCSCiuc009bba.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.
BC151071 mRNA Translation: AAI51072.1
CCDSiCCDS39437.1
RefSeqiNP_001074775.1, NM_001081306.1
UniGeneiMm.41639

3D structure databases

ProteinModelPortaliB9EKR1
SMRiB9EKR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202509, 1 interactor
IntActiB9EKR1, 1 interactor
STRINGi10090.ENSMUSP00000088056

PTM databases

iPTMnetiB9EKR1
PhosphoSitePlusiB9EKR1

Proteomic databases

MaxQBiB9EKR1
PaxDbiB9EKR1
PeptideAtlasiB9EKR1
PRIDEiB9EKR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748
GeneIDi19283
KEGGimmu:19283
UCSCiuc009bba.1 mouse

Organism-specific databases

CTDi5803
MGIiMGI:97816 Ptprz1

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000090262
HOVERGENiHBG053760
InParanoidiB9EKR1
KOiK08114
OrthoDBiEOG091G018S
PhylomeDBiB9EKR1
TreeFamiTF351978

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Miscellaneous databases

ChiTaRSiPtprz1 mouse
PROiPR:B9EKR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiB9EKR1 baseline and differential
GenevisibleiB9EKR1 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRPTZ_MOUSE
AccessioniPrimary (citable) accession number: B9EKR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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