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UniProtKB - B9EKR1 (PRPTZ_MOUSE)

Protein

Receptor-type tyrosine-protein phosphatase zeta

Gene

Ptprz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1898SubstrateBy similarity1
Active sitei1930Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1974SubstrateBy similarity1
Sitei2220Ancestral active siteBy similarity1

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI
  • phosphatase activity Source: MGI
  • protein tyrosine phosphatase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase zeta (EC:3.1.3.481 Publication)
Short name:
R-PTP-zeta
Gene namesi
Name:Ptprz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97816 Ptprz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1637ExtracellularSequence analysisAdd BLAST1613
Transmembranei1638 – 1658HelicalSequence analysisAdd BLAST21
Topological domaini1659 – 2312CytoplasmicSequence analysisAdd BLAST654

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian rate, are viable and fertile (PubMed:11003666). Embryonic mutant mice show increased levels of oligodendrocyte precursor cells in the spinal cord, combined with impaired differentiation of the precursor cells into mature, fully myelinating oligodendrocytes (PubMed:21969550). Mutant mice show slightly increased susceptibility to experimental autoimmune encephalomyelitis (EAE) and strongly reduced recovery. Contrary to wild-type, mutant mice remain paralyzed and display increased levels of apoptotic oligodendrocytes in the spinal cord (PubMed:12355066). Besides, mutant mice display impaired contextual fear memory, probably due to impaired dephosphorylation of proteins that are part of important signaling cascades (PubMed:16513268).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000042488225 – 2312Receptor-type tyrosine-protein phosphatase zetaAdd BLAST2288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 240By similarity
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 264By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei572PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei645PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1058N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1559N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1681PhosphothreonineCombined sources1
Modified residuei1684PhosphothreonineCombined sources1
Modified residuei2052PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiB9EKR1
PaxDbiB9EKR1
PeptideAtlasiB9EKR1
PRIDEiB9EKR1

PTM databases

iPTMnetiB9EKR1
PhosphoSitePlusiB9EKR1

Expressioni

Tissue specificityi

Detected in neurons and astrocytes in the central nervous system (CNS). Detected in the hippocampus and in brain cortex.2 Publications

Gene expression databases

BgeeiENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiB9EKR1 baseline and differential
GenevisibleiB9EKR1 MM

Interactioni

Subunit structurei

The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774, PubMed:21969550). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi202509, 1 interactor
IntActiB9EKR1, 1 interactor
STRINGi10090.ENSMUSP00000088056

Structurei

3D structure databases

ProteinModelPortaliB9EKR1
SMRiB9EKR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 300Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST265
Domaini314 – 413Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini1714 – 1989Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST276
Domaini2020 – 2279Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1930 – 1936Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi951 – 954Poly-Ser4
Compositional biasi1225 – 1230Poly-Ser6
Compositional biasi1426 – 1439Poly-AspAdd BLAST14

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000090262
HOVERGENiHBG053760
InParanoidiB9EKR1
KOiK08114
OrthoDBiEOG091G018S
PhylomeDBiB9EKR1
TreeFamiTF351978

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B9EKR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRILQSFLAC VQLLCLCRLD WAYGYYRQQR KLVEEIGWSY TGALNQKNWG 
        60         70         80         90        100
KKYPICNSPK QSPINIDEDL TQVNVNLKKL KFQGWEKASL ENTFIHNTGK 
       110        120        130        140        150
TVEINLTNDY YLSGGLSEKV FKASKITFHW GKCNVSSEGS EHSLEGQKFP 
       160        170        180        190        200
LEMQVYCFDA DRFSSFEEAV KGKGRLRALS ILFEVGVEEN LDYKAIIDGT 
       210        220        230        240        250
ESVSRFGKQA ALDPFVLQNL LPNSTDKYYI YNGSLTSPPC TDTVEWIVFK 
       260        270        280        290        300
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY 
       310        320        330        340        350
TGKEEIHEVV CSSEPENVQA DPENYTSLLV TWERPRVVYD AMIEKFAVLY 
       360        370        380        390        400
QPLAGNDQAK HEFLTDGYQD LGAILNNLLP NMSYVLQIVA VCSNGLYGKY 
       410        420        430        440        450
SDQLIVDMPT EDAELDLFPE LIGTEEIIKE EEYGKDNEED TGLNPGRDSV 
       460        470        480        490        500
TNQIRKKEPQ VSTTTHYNHM GTKYNEAKTN RSPTRGSEFS GKSDVPNTSP 
       510        520        530        540        550
NSTSQHVAEF ETERGISLPS QTGTNLPPHN VEGTSASLNS GSKTLFIFPQ 
       560        570        580        590        600
MNLSGTAESL NTVPITEYKE VSADVSEEEN FLTDFKLDTG ADDSSGSSPS 
       610        620        630        640        650
TSTVPFSSDN LSHGYITSSD MPEAITYDVL KPGSTRNAPE DSAPSGSEES 
       660        670        680        690        700
LKDPSLEGSV WFPGSTDLTT QSETGSGRES FLQVNSTDIQ IDESRETTES 
       710        720        730        740        750
FSPDATVSQD PSVTDMGMPH YSTFAYLPTE VTPQAFTPSS RPLDLAPTIN 
       760        770        780        790        800
ILHSQTTQPV YNGETPLQPS YSSEVFPLAT PLLLDNQTLN TTPAASSSDS 
       810        820        830        840        850
ALHATPVSPS VGVSFESILS SYDDAPLLPF SSASFSSEMF RHLHTVSQTL 
       860        870        880        890        900
PQVTSAAERD ELSLHASLLV ARGDLLLEPS LVQYSDVASH QATTRAASDT 
       910        920        930        940        950
LGFGSESAVF YKTSMVSQIE SPRSDVVMHA YSSGPEPSYT VEGSHHVPTV 
       960        970        980        990       1000
SYSSAMPLHG SVDVSDQGSL LINPSHISMP ESSFITPTAS LLQPPPALSG 
      1010       1020       1030       1040       1050
DGEWSGASSD SELLLPDADG LRTLNISSPV SVAEFTYTTS VFADGIKPLS 
      1060       1070       1080       1090       1100
KSEMMYGNET ELKMSSFSDM AYPSKSTVVP KMSDVVHKWS ESLKETSVSI 
      1110       1120       1130       1140       1150
SSMKSVFPES LVYPTTKGFE QGVSHVPEII FPVQPTHTAS QASGDTWLKP 
      1160       1170       1180       1190       1200
GLSANSEAAF SDTASREVVH PSTQPLLYEA ATPFNTEALL QPSFQASDVD 
      1210       1220       1230       1240       1250
TLLKTALPSV PSDPILAGTP QVEQSSSSVS HPMASESGSS ESMLHFTSVP 
      1260       1270       1280       1290       1300
ILDISPSKVH STPLQGLTVP HSSKKFSEQG LLKSKSPQQV LPSLFSNDEF 
      1310       1320       1330       1340       1350
FQSAHLDVSQ AYPPKGRHAF VTPVLSIDEP QNTLINKLVY SEDIFSSTEI 
      1360       1370       1380       1390       1400
SITDKVLTGL PTLASDVLSS TDHSVPLGSG PISLTMVSPN RDDSVTTAKL 
      1410       1420       1430       1440       1450
LLPSTATSKL TQSARSDADL VGGGEDGDDY DDDDYDDIDR GRFPVNKCMS 
      1460       1470       1480       1490       1500
CLPYRESREK VMNDSDTQES SLVDQSDPIS PLLFENTEEE NGGTGVTRVD 
      1510       1520       1530       1540       1550
KSPPPSMLPQ NHNDGKEDSD IQMGSAVLPH TPGSKAWAVL TSDEESGSGQ 
      1560       1570       1580       1590       1600
GTSDSLNDNE TSTDFSFPDV NEKDTDGVLE TDDTGIAPGS PRSSTPSVTS 
      1610       1620       1630       1640       1650
GHSGVSNSSE AEASNSSHES RIGLAEGLES EKKAVIPLVI VSALTFICLV 
      1660       1670       1680       1690       1700
VLVGILIYWR KCFQTAHFYL EDNTSPRVIS TPPTPIFPIS DDIGAIPIKH 
      1710       1720       1730       1740       1750
FPKHVADLHA SNGFTEEFET LKEFYQEVQS CTADLGITAD SSNHPDNKHK 
      1760       1770       1780       1790       1800
NRYVNIVAYD HSRVKLTQLA EKDGKLTDYI NANYVDGYNR PKAYIAAQGP 
      1810       1820       1830       1840       1850
LKSTAEDFWR MIWEHNVEVI VMITNLVEKG RRKCDQYWPT DGSEEYGSFL 
      1860       1870       1880       1890       1900
VNQKSVQVLA YYTVRNFTLR NTKLKKGSQK GRSSGRLVTQ YHYTQWPDMG 
      1910       1920       1930       1940       1950
VPEYSLPVLA FVRKAAQAKR HAVGPVVVHC SAGVGRTGTY IVLDSMLQQI 
      1960       1970       1980       1990       2000
QHEGTVNIFG FLKHIRSQRN YLVQTEEQYV FIHDTLVEAI LSKETEVPDS 
      2010       2020       2030       2040       2050
HIHSYVNTLL IPGPTGKTKL EKQFQLLSQS NILQSDYSTA LKQCNREKNR 
      2060       2070       2080       2090       2100
TSSIIPVERS RVGISSLSGE GTDYINASYI MGYYQSNEFI ITQHPLLHTI 
      2110       2120       2130       2140       2150
KDFWRMIWDH NAQLVVMIPD GQNMAEDEFV YWPNKDEPIN CESFKVTLMS 
      2160       2170       2180       2190       2200
EEHKCLSNEE KLIVQDFILE ATQDDYVLEV RHFQCPKWPN PDSPISKTFE 
      2210       2220       2230       2240       2250
LISIIKEEAA NRDGPMIVHD EHGGVTAGTF CALTTLMHQL EKENAMDVYQ 
      2260       2270       2280       2290       2300
VAKMINLMRP GVFTDIEQYQ FLYKVVLSLV STRQEENPST SLDSNGAALP 
      2310 
DGNIAESLES LV
Length:2,312
Mass (Da):254,405
Last modified:March 24, 2009 - v1
Checksum:i91C5D58F74BA999C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RXS8B2RXS8_MOUSE
Ptprz1 protein
Ptprz1
1,463Annotation score:
A0A0J9YVD2A0A0J9YVD2_MOUSE
Receptor-type tyrosine-protein phos...
Ptprz1
1,612Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.
BC151071 mRNA Translation: AAI51072.1
CCDSiCCDS39437.1
RefSeqiNP_001074775.1, NM_001081306.1
UniGeneiMm.41639

Genome annotation databases

EnsembliENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748
GeneIDi19283
KEGGimmu:19283
UCSCiuc009bba.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133599 Genomic DNA No translation available.
AC134445 Genomic DNA No translation available.
BC151071 mRNA Translation: AAI51072.1
CCDSiCCDS39437.1
RefSeqiNP_001074775.1, NM_001081306.1
UniGeneiMm.41639

3D structure databases

ProteinModelPortaliB9EKR1
SMRiB9EKR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202509, 1 interactor
IntActiB9EKR1, 1 interactor
STRINGi10090.ENSMUSP00000088056

PTM databases

iPTMnetiB9EKR1
PhosphoSitePlusiB9EKR1

Proteomic databases

MaxQBiB9EKR1
PaxDbiB9EKR1
PeptideAtlasiB9EKR1
PRIDEiB9EKR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748
GeneIDi19283
KEGGimmu:19283
UCSCiuc009bba.1 mouse

Organism-specific databases

CTDi5803
MGIiMGI:97816 Ptprz1

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000090262
HOVERGENiHBG053760
InParanoidiB9EKR1
KOiK08114
OrthoDBiEOG091G018S
PhylomeDBiB9EKR1
TreeFamiTF351978

Enzyme and pathway databases

ReactomeiR-MMU-449836 Other interleukin signaling

Miscellaneous databases

ChiTaRSiPtprz1 mouse
PROiPR:B9EKR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068748 Expressed in 249 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiB9EKR1 baseline and differential
GenevisibleiB9EKR1 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPRPTZ_MOUSE
AccessioniPrimary (citable) accession number: B9EKR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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