UniProtKB - B9EKR1 (PTPRZ_MOUSE)
Receptor-type tyrosine-protein phosphatase zeta
Ptprz1
Functioni
Catalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphatePROSITE-ProRule annotation1 PublicationEC:3.1.3.48PROSITE-ProRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1898 | SubstrateBy similarity | 1 | |
Active sitei | 1930 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 1974 | SubstrateBy similarity | 1 | |
Sitei | 2220 | Ancestral active siteBy similarity | 1 |
GO - Molecular functioni
- fibroblast growth factor binding Source: MGI
- integrin binding Source: UniProtKB
- phosphatase activity Source: UniProtKB
- protein tyrosine phosphatase activity Source: UniProtKB
GO - Biological processi
- axonal fasciculation Source: MGI
- axonogenesis Source: MGI
- hematopoietic progenitor cell differentiation Source: MGI
- learning or memory Source: UniProtKB
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cell-substrate adhesion Source: MGI
- negative regulation of dendrite development Source: MGI
- negative regulation of neuron apoptotic process Source: UniProtKB
- oligodendrocyte differentiation Source: UniProtKB
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of dendrite development Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of neuron death Source: MGI
- positive regulation of neuron migration Source: MGI
- positive regulation of neuron projection development Source: MGI
- positive regulation of oligodendrocyte differentiation Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of Schwann cell migration Source: MGI
- protein dephosphorylation Source: MGI
- regulation of dendrite morphogenesis Source: MGI
- regulation of myelination Source: UniProtKB
- regulation of oligodendrocyte progenitor proliferation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
Reactomei | R-MMU-449836, Other interleukin signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase zeta (EC:3.1.3.481 Publication)Short name: R-PTP-zeta |
Gene namesi | Name:Ptprz1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97816, Ptprz1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Note: A secreted form is apparently generated by shedding of the extracellular domain.
Extracellular region or secreted
- extracellular matrix Source: MGI
- extracellular space Source: MGI
- perineuronal net Source: MGI
Plasma Membrane
- integral component of postsynaptic density membrane Source: MGI
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: MGI
- ruffle membrane Source: MGI
Other locations
- axon Source: MGI
- cytoplasm Source: MGI
- dendrite Source: MGI
- dendritic spine Source: MGI
- filopodium Source: MGI
- glutamatergic synapse Source: MGI
- growth cone Source: MGI
- lamellipodium Source: MGI
- membrane Source: MGI
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 1637 | ExtracellularSequence analysisAdd BLAST | 1613 | |
Transmembranei | 1638 – 1658 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1659 – 2312 | CytoplasmicSequence analysisAdd BLAST | 654 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000424882 | 25 – 2312 | Receptor-type tyrosine-protein phosphatase zetaAdd BLAST | 2288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 240 | By similarity | ||
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 133 ↔ 264 | By similarity | ||
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 572 | PhosphoserineCombined sources | 1 | |
Modified residuei | 576 | PhosphoserineCombined sources | 1 | |
Modified residuei | 645 | PhosphoserineBy similarity | 1 | |
Modified residuei | 647 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1025 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1058 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1559 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1681 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1684 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2052 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | B9EKR1 |
MaxQBi | B9EKR1 |
PaxDbi | B9EKR1 |
PeptideAtlasi | B9EKR1 |
PRIDEi | B9EKR1 |
PTM databases
GlyConnecti | 2675, 10 N-Linked glycans (3 sites) |
GlyGeni | B9EKR1, 10 sites |
iPTMneti | B9EKR1 |
PhosphoSitePlusi | B9EKR1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000068748, Expressed in vestibular membrane of cochlear duct and 267 other tissues |
ExpressionAtlasi | B9EKR1, baseline and differential |
Genevisiblei | B9EKR1, MM |
Interactioni
Subunit structurei
The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774, PubMed:21969550). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity).
Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- fibroblast growth factor binding Source: MGI
- integrin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 202509, 5 interactors |
IntActi | B9EKR1, 1 interactor |
STRINGi | 10090.ENSMUSP00000088056 |
Miscellaneous databases
RNActi | B9EKR1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 300 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 265 | |
Domaini | 314 – 413 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1714 – 1989 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 276 | |
Domaini | 2020 – 2279 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 260 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1930 – 1936 | Substrate bindingBy similarity | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 951 – 954 | Poly-Ser | 4 | |
Compositional biasi | 1225 – 1230 | Poly-Ser | 6 | |
Compositional biasi | 1426 – 1439 | Poly-AspAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000155529 |
HOGENOMi | CLU_001120_1_0_1 |
InParanoidi | B9EKR1 |
OrthoDBi | 251520at2759 |
PhylomeDBi | B9EKR1 |
TreeFami | TF351978 |
Family and domain databases
CDDi | cd03122, alpha_CARP_receptor_like, 1 hit cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.200.10, 1 hit 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR041887, Alpha_CARP_receptor-type IPR001148, CA_dom IPR036398, CA_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit PF00041, fn3, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit SM00060, FN3, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF51069, SSF51069, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit PS50853, FN3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MRILQSFLAC VQLLCLCRLD WAYGYYRQQR KLVEEIGWSY TGALNQKNWG
60 70 80 90 100
KKYPICNSPK QSPINIDEDL TQVNVNLKKL KFQGWEKASL ENTFIHNTGK
110 120 130 140 150
TVEINLTNDY YLSGGLSEKV FKASKITFHW GKCNVSSEGS EHSLEGQKFP
160 170 180 190 200
LEMQVYCFDA DRFSSFEEAV KGKGRLRALS ILFEVGVEEN LDYKAIIDGT
210 220 230 240 250
ESVSRFGKQA ALDPFVLQNL LPNSTDKYYI YNGSLTSPPC TDTVEWIVFK
260 270 280 290 300
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY
310 320 330 340 350
TGKEEIHEVV CSSEPENVQA DPENYTSLLV TWERPRVVYD AMIEKFAVLY
360 370 380 390 400
QPLAGNDQAK HEFLTDGYQD LGAILNNLLP NMSYVLQIVA VCSNGLYGKY
410 420 430 440 450
SDQLIVDMPT EDAELDLFPE LIGTEEIIKE EEYGKDNEED TGLNPGRDSV
460 470 480 490 500
TNQIRKKEPQ VSTTTHYNHM GTKYNEAKTN RSPTRGSEFS GKSDVPNTSP
510 520 530 540 550
NSTSQHVAEF ETERGISLPS QTGTNLPPHN VEGTSASLNS GSKTLFIFPQ
560 570 580 590 600
MNLSGTAESL NTVPITEYKE VSADVSEEEN FLTDFKLDTG ADDSSGSSPS
610 620 630 640 650
TSTVPFSSDN LSHGYITSSD MPEAITYDVL KPGSTRNAPE DSAPSGSEES
660 670 680 690 700
LKDPSLEGSV WFPGSTDLTT QSETGSGRES FLQVNSTDIQ IDESRETTES
710 720 730 740 750
FSPDATVSQD PSVTDMGMPH YSTFAYLPTE VTPQAFTPSS RPLDLAPTIN
760 770 780 790 800
ILHSQTTQPV YNGETPLQPS YSSEVFPLAT PLLLDNQTLN TTPAASSSDS
810 820 830 840 850
ALHATPVSPS VGVSFESILS SYDDAPLLPF SSASFSSEMF RHLHTVSQTL
860 870 880 890 900
PQVTSAAERD ELSLHASLLV ARGDLLLEPS LVQYSDVASH QATTRAASDT
910 920 930 940 950
LGFGSESAVF YKTSMVSQIE SPRSDVVMHA YSSGPEPSYT VEGSHHVPTV
960 970 980 990 1000
SYSSAMPLHG SVDVSDQGSL LINPSHISMP ESSFITPTAS LLQPPPALSG
1010 1020 1030 1040 1050
DGEWSGASSD SELLLPDADG LRTLNISSPV SVAEFTYTTS VFADGIKPLS
1060 1070 1080 1090 1100
KSEMMYGNET ELKMSSFSDM AYPSKSTVVP KMSDVVHKWS ESLKETSVSI
1110 1120 1130 1140 1150
SSMKSVFPES LVYPTTKGFE QGVSHVPEII FPVQPTHTAS QASGDTWLKP
1160 1170 1180 1190 1200
GLSANSEAAF SDTASREVVH PSTQPLLYEA ATPFNTEALL QPSFQASDVD
1210 1220 1230 1240 1250
TLLKTALPSV PSDPILAGTP QVEQSSSSVS HPMASESGSS ESMLHFTSVP
1260 1270 1280 1290 1300
ILDISPSKVH STPLQGLTVP HSSKKFSEQG LLKSKSPQQV LPSLFSNDEF
1310 1320 1330 1340 1350
FQSAHLDVSQ AYPPKGRHAF VTPVLSIDEP QNTLINKLVY SEDIFSSTEI
1360 1370 1380 1390 1400
SITDKVLTGL PTLASDVLSS TDHSVPLGSG PISLTMVSPN RDDSVTTAKL
1410 1420 1430 1440 1450
LLPSTATSKL TQSARSDADL VGGGEDGDDY DDDDYDDIDR GRFPVNKCMS
1460 1470 1480 1490 1500
CLPYRESREK VMNDSDTQES SLVDQSDPIS PLLFENTEEE NGGTGVTRVD
1510 1520 1530 1540 1550
KSPPPSMLPQ NHNDGKEDSD IQMGSAVLPH TPGSKAWAVL TSDEESGSGQ
1560 1570 1580 1590 1600
GTSDSLNDNE TSTDFSFPDV NEKDTDGVLE TDDTGIAPGS PRSSTPSVTS
1610 1620 1630 1640 1650
GHSGVSNSSE AEASNSSHES RIGLAEGLES EKKAVIPLVI VSALTFICLV
1660 1670 1680 1690 1700
VLVGILIYWR KCFQTAHFYL EDNTSPRVIS TPPTPIFPIS DDIGAIPIKH
1710 1720 1730 1740 1750
FPKHVADLHA SNGFTEEFET LKEFYQEVQS CTADLGITAD SSNHPDNKHK
1760 1770 1780 1790 1800
NRYVNIVAYD HSRVKLTQLA EKDGKLTDYI NANYVDGYNR PKAYIAAQGP
1810 1820 1830 1840 1850
LKSTAEDFWR MIWEHNVEVI VMITNLVEKG RRKCDQYWPT DGSEEYGSFL
1860 1870 1880 1890 1900
VNQKSVQVLA YYTVRNFTLR NTKLKKGSQK GRSSGRLVTQ YHYTQWPDMG
1910 1920 1930 1940 1950
VPEYSLPVLA FVRKAAQAKR HAVGPVVVHC SAGVGRTGTY IVLDSMLQQI
1960 1970 1980 1990 2000
QHEGTVNIFG FLKHIRSQRN YLVQTEEQYV FIHDTLVEAI LSKETEVPDS
2010 2020 2030 2040 2050
HIHSYVNTLL IPGPTGKTKL EKQFQLLSQS NILQSDYSTA LKQCNREKNR
2060 2070 2080 2090 2100
TSSIIPVERS RVGISSLSGE GTDYINASYI MGYYQSNEFI ITQHPLLHTI
2110 2120 2130 2140 2150
KDFWRMIWDH NAQLVVMIPD GQNMAEDEFV YWPNKDEPIN CESFKVTLMS
2160 2170 2180 2190 2200
EEHKCLSNEE KLIVQDFILE ATQDDYVLEV RHFQCPKWPN PDSPISKTFE
2210 2220 2230 2240 2250
LISIIKEEAA NRDGPMIVHD EHGGVTAGTF CALTTLMHQL EKENAMDVYQ
2260 2270 2280 2290 2300
VAKMINLMRP GVFTDIEQYQ FLYKVVLSLV STRQEENPST SLDSNGAALP
2310
DGNIAESLES LV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB2RXS8 | B2RXS8_MOUSE | Protein-tyrosine-phosphatase | Ptprz1 | 1,463 | Annotation score: | ||
A0A0J9YVD2 | A0A0J9YVD2_MOUSE | Receptor-type tyrosine-protein phos... | Ptprz1 | 1,612 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133599 Genomic DNA No translation available. AC134445 Genomic DNA No translation available. BC151071 mRNA Translation: AAI51072.1 |
CCDSi | CCDS39437.1 |
RefSeqi | NP_001074775.1, NM_001081306.1 |
Genome annotation databases
Ensembli | ENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748 |
GeneIDi | 19283 |
KEGGi | mmu:19283 |
UCSCi | uc009bba.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133599 Genomic DNA No translation available. AC134445 Genomic DNA No translation available. BC151071 mRNA Translation: AAI51072.1 |
CCDSi | CCDS39437.1 |
RefSeqi | NP_001074775.1, NM_001081306.1 |
3D structure databases
SMRi | B9EKR1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202509, 5 interactors |
IntActi | B9EKR1, 1 interactor |
STRINGi | 10090.ENSMUSP00000088056 |
PTM databases
GlyConnecti | 2675, 10 N-Linked glycans (3 sites) |
GlyGeni | B9EKR1, 10 sites |
iPTMneti | B9EKR1 |
PhosphoSitePlusi | B9EKR1 |
Proteomic databases
jPOSTi | B9EKR1 |
MaxQBi | B9EKR1 |
PaxDbi | B9EKR1 |
PeptideAtlasi | B9EKR1 |
PRIDEi | B9EKR1 |
Protocols and materials databases
Antibodypediai | 2175, 195 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000090568; ENSMUSP00000088056; ENSMUSG00000068748 |
GeneIDi | 19283 |
KEGGi | mmu:19283 |
UCSCi | uc009bba.1, mouse |
Organism-specific databases
CTDi | 5803 |
MGIi | MGI:97816, Ptprz1 |
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000155529 |
HOGENOMi | CLU_001120_1_0_1 |
InParanoidi | B9EKR1 |
OrthoDBi | 251520at2759 |
PhylomeDBi | B9EKR1 |
TreeFami | TF351978 |
Enzyme and pathway databases
Reactomei | R-MMU-449836, Other interleukin signaling |
Miscellaneous databases
BioGRID-ORCSi | 19283, 1 hit in 17 CRISPR screens |
ChiTaRSi | Ptprz1, mouse |
PROi | PR:B9EKR1 |
RNActi | B9EKR1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068748, Expressed in vestibular membrane of cochlear duct and 267 other tissues |
ExpressionAtlasi | B9EKR1, baseline and differential |
Genevisiblei | B9EKR1, MM |
Family and domain databases
CDDi | cd03122, alpha_CARP_receptor_like, 1 hit cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.200.10, 1 hit 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR041887, Alpha_CARP_receptor-type IPR001148, CA_dom IPR036398, CA_dom_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit PF00041, fn3, 1 hit PF00102, Y_phosphatase, 2 hits |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit SM00060, FN3, 1 hit SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF51069, SSF51069, 1 hit SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit PS50853, FN3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPRZ_MOUSE | |
Accessioni | B9EKR1Primary (citable) accession number: B9EKR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 22, 2014 |
Last sequence update: | March 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families