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Entry version 70 (31 Jul 2019)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Mon2 protein

Gene

Mon2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mon2 proteinImported
Submitted name:
Protein MON2 homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mon2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914324 Mon2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 184DCBInterPro annotationAdd BLAST176
Domaini211 – 384Sec7_NInterPro annotationAdd BLAST174
Domaini851 – 928DUF1981InterPro annotationAdd BLAST78
Domaini932 – 1700Mon2_CInterPro annotationAdd BLAST769

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni506 – 540DisorderedSequence analysisAdd BLAST35

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013286

Database of Orthologous Groups

More...
OrthoDBi
411011at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N

The PANTHER Classification System

More...
PANTHERi
PTHR10663:SF333 PTHR10663:SF333, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B9EKJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCTNSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA
60 70 80 90 100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS
110 120 130 140 150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC
160 170 180 190 200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDDRHRDI EPPVPIQGNS
210 220 230 240 250
NRRSVSTLRP CAKDAYMLFQ DLCQLVNADA PYWLVGMTEM TRTFGLELLE
260 270 280 290 300
SVLNDFPQVF LQHQEFSFLL KERVCPLVIK LFSPNIKFRQ GSSTSSSPAP
310 320 330 340 350
VEKPYFPICM RLLRVVSVLI KQFYSLLVTE CEIFLSLLVK FLDSDKPQWL
360 370 380 390 400
RAVAVESIHR LCVQPQLLRS FCQSYDMKQH STKVFRDIVN ALGSFIQSLF
410 420 430 440 450
LVPPTGNPAT ANQAGNNNAG GPASAPANSG VVGVGGGVTL LPAFEYRGAW
460 470 480 490 500
IPILTVTVQG SAKATYLEML DKVEPPTIPE GYAMSVAFHC LLDLVRGITT
510 520 530 540 550
MIEGELGEVE AEGPSVTEGA SSQSSERRDE QAASDPMDQE TAVSRAVWEE
560 570 580 590 600
MVSACWCGLL AALSLLLDAS TDEAATENIL KAELTMAALC GRLGLVTSRD
610 620 630 640 650
AFITAICKGS LPPHYALTVL NATTAATLSN KSYSIQGQSV MMISPSSESH
660 670 680 690 700
QQVVAVGQPL AVQPQGTVML TSKNIQCMRT LLNLAHCHGA VLGTSWQLVL
710 720 730 740 750
ATLQHLVWIL GLKPSSGGAL KPGRAVEGPS TVLTTAVMTD LPVISNILSR
760 770 780 790 800
LFESSQYLDD VSLHHLINAL CSLSLEAMDM AYGNNKEPSL FAVAKLLETG
810 820 830 840 850
LVNMHRIEIL WRPLTGHLLE VCQHPNSRMR EWGAEALTSL IRAGLTFSHE
860 870 880 890 900
PPLPQNQRLQ LLLLNPLKEM SNINHPDIRL KQLECVLQIL QSQGDSLGPG
910 920 930 940 950
WPLVLGVMGA IRNDQGESLI RTAFQCLQLV VTDFLPTMPC SCLQIVVDVA
960 970 980 990 1000
GSFGLHNQEL NISLTSIGLL WNISDYFFQR GETIEKELNK EEAAQQKQAE
1010 1020 1030 1040 1050
EKGVSLNRPF HPAPPFDCLW LCLYAKLGEL CVDPRPAVRK SAGQTLFSTI
1060 1070 1080 1090 1100
GAHGTLLQHS TWHTVIWKVL FHLLDRVRES STTADKEKIE SGGGNILIHH
1110 1120 1130 1140 1150
SRDTAEKQWA ETWVLTLAGV ARIFNTRRYL LQPLGDFSRA WDVLLDHIQS
1160 1170 1180 1190 1200
AALSKNNEVS LAALKSFQEI LQIVSPVRDS EKPEPPAVSV PVPVLLGNLS
1210 1220 1230 1240 1250
GPGLSRPFVR TDSIGEKLGR CGSETPVVTD ELEDLKLWWA AWNTWHRTGS
1260 1270 1280 1290 1300
ESTEPPSSVD ELTFIPSQPF LTALVQIFPA LYQHIKAGFS MADLQKLGVI
1310 1320 1330 1340 1350
LHSAVSVPIS SDASPFILPS YTEAVLTSLQ EAVLTALDVL QKAICVGPEN
1360 1370 1380 1390 1400
MQIMYPAIFD QLLAFVEFSC KPPQYGQLET KHIANAKYNQ AEWVALNYVP
1410 1420 1430 1440 1450
FAERSLEVVV DLYQKTACHK AVVNEKVLQN IIKTLRVPLS LKYSCPSEST
1460 1470 1480 1490 1500
WKLAVASLLK VLSIGLPVAR QHASSGKFDS MWPELASTLE DFLFTKSIPP
1510 1520 1530 1540 1550
DNLSIQEFQR NESIDVEVVQ LISAEILPYA NLIPKAFVGQ MMTMLNKGSI
1560 1570 1580 1590 1600
HSQPCSFTEA EIDIRLREEF SKMCFETLLQ FSFSNKVTTP QEGYISRMAL
1610 1620 1630 1640 1650
SVLLKRSQDV LHRYIEDERL SGKCPLPRQQ VTEIIFVLKA VSTLIDSLKK
1660 1670 1680 1690 1700
TQPENVDGNT WSQVIALYPT LVECITCSSS DVGSALKEAL APFKDFMQPP

ASRVQNGES
Length:1,709
Mass (Da):188,352
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i729895DDF5C09075
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TL7MON2_MOUSE
Protein MON2 homolog
Mon2 Kiaa1040, Sf21
1,715Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P878A0A1W2P878_MOUSE
Protein MON2 homolog
Mon2
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC153021 Genomic DNA No translation available.
AC153911 Genomic DNA No translation available.
BC150943 mRNA Translation: AAI50944.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156497.1, NM_001163025.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000170935; ENSMUSP00000131052; ENSMUSG00000034602

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67074

UCSC genome browser

More...
UCSCi
uc011xpe.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153021 Genomic DNA No translation available.
AC153911 Genomic DNA No translation available.
BC150943 mRNA Translation: AAI50944.1
RefSeqiNP_001156497.1, NM_001163025.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000170935; ENSMUSP00000131052; ENSMUSG00000034602
GeneIDi67074
UCSCiuc011xpe.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23041
MGIiMGI:1914324 Mon2

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
OrthoDBi411011at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mon2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR10663:SF333 PTHR10663:SF333, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9EKJ3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9EKJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: July 31, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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