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Protein

TATA element modulatory factor

Gene

Tmf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
TATA element modulatory factor
Short name:
TMF
Alternative name(s):
Androgen receptor coactivator 160 kDa protein
Androgen receptor-associated protein of 160 kDa
Gene namesi
Name:Tmf1
Synonyms:Ara160, Gm153
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2684999 Tmf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003767971 – 1091TATA element modulatory factorAdd BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei324PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei340PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei540PhosphoserineBy similarity1
Modified residuei923PhosphoserineBy similarity1
Modified residuei926PhosphoserineCombined sources1
Modified residuei927PhosphothreonineCombined sources1
Modified residuei931PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by FER.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB9EKI3
MaxQBiB9EKI3
PaxDbiB9EKI3
PeptideAtlasiB9EKI3
PRIDEiB9EKI3

PTM databases

iPTMnetiB9EKI3
PhosphoSitePlusiB9EKI3

Expressioni

Gene expression databases

BgeeiENSMUSG00000030059 Expressed in 232 organ(s), highest expression level in testis
ExpressionAtlasiB9EKI3 baseline and differential

Interactioni

Subunit structurei

Component of the SNF/SWI transcription factor complexes (By similarity). Interacts with RAB6A. Interacts with TCEB1 (By similarity). Interacts with STAT3 and FER. Interacts with TRNP1; may regulate TRNP1 proteasomal degradation.By similarity2 Publications

Protein-protein interaction databases

BioGridi231235, 4 interactors
IntActiB9EKI3, 1 interactor
STRINGi10090.ENSMUSP00000093325

Structurei

3D structure databases

SMRiB9EKI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni329 – 338Interaction with Elongin BC complexBy similarity10

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili443 – 767Sequence analysisAdd BLAST325
Coiled coili824 – 894Sequence analysisAdd BLAST71
Coiled coili984 – 1090Sequence analysisAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 340Ser-richAdd BLAST106
Compositional biasi374 – 377Poly-Glu4

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGA0 Eukaryota
ENOG410YE9Z LUCA
GeneTreeiENSGT00390000010697
HOGENOMiHOG000154639
InParanoidiB9EKI3
KOiK20286
OMAiGEISHLQ
OrthoDBiEOG091G01F7
TreeFamiTF329420

Family and domain databases

InterProiView protein in InterPro
IPR022092 TMF_DNA-bd
IPR022091 TMF_TATA-bd
PfamiView protein in Pfam
PF12329 TMF_DNA_bd, 1 hit
PF12325 TMF_TATA_bd, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B9EKI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSAWAE AIPYGEPGIS
60 70 80 90 100
PPVSGGWDTS TWGLNSTSSE PQSPPTASQA ITKPVRRTVV DESENFFSAF
110 120 130 140 150
LSPSDAHTIQ KSPVVSKPPS KSQRPEEEVK SSLQESSSPG QSRVSETAEV
160 170 180 190 200
RDSVCVSGET SAVGTPSPVP EDKHEETAGE ESEVKVPTVR LKASENVVNV
210 220 230 240 250
NTTEDVSTTS TQSLTAETKD MALEPKEQKH EDRQSNTPSP PVSSFSSGTS
260 270 280 290 300
TTSDIEVLDH ESVISESSAS SRQETSDAKS SLHLMQTSFQ LLSASACPEY
310 320 330 340 350
SRLDDFQKLN ESCCSSDAFE RIDSFSVQSL DSRSVSEINS DDELPGKGYA
360 370 380 390 400
LVPIIVSPST PKTKVVESTE ENAEEEEGNE TLVAPSEEAE LEESGRSATP
410 420 430 440 450
VNCDQPDILA SPTAGSGGHS ASGPATEQCE AVENQPKAPP EKEDVCKTVE
460 470 480 490 500
FLNEKLEKRE TQLLSLSKEK ALLEEAYDNL KDEMFRVKEE SSSISSLKDE
510 520 530 540 550
FTQRIAEAEK KVQLACKERD AAKKEMKTIK EELATRLNSS QTADLLKEKD
560 570 580 590 600
EQIQGLMEEG EKLSKQQLHN SNIIKKLRAK DKDNENVIAK LNRKAKELEE
610 620 630 640 650
ELQHLRQVLD GKEEVEKQHR ENIKKLNSVV ERQEKDLGRL QVDMDELEEK
660 670 680 690 700
SRSTQAALDS AYRELTDLHK ANAAKDSEVQ EAALRREMKA KEELSGALEK
710 720 730 740 750
AQEEARQQQE ALVLQVGDLR LALQRAEQAA ARKEDYLRHE ISELQQRLQE
760 770 780 790 800
AENRNQELSQ SVSSTARPLL RQIENLQATL GSQTSSWETL EKSLSDRLGE
810 820 830 840 850
SQTLLAAAVE RERAATEELL ANKIQMSSVE SQNTLLRQEN SRLQAQLESE
860 870 880 890 900
KNKLRKLEDE NSRYQVELEN LKDEYVRTLE ESRKEKTLLS SQLEMERMKV
910 920 930 940 950
EQERKKTIFT QEALKEKDHK LFSVCSTPTM SRSSSISGVD AAGLQASFLS
960 970 980 990 1000
QDESHDHSFG PMSTSASGSN LYEAVRMGAG SSIIENLQSQ LKLREGEISH
1010 1020 1030 1040 1050
LQLEISNLEK TRSIMSEELV KLTNQNDELE EKVKEIPKLR VQLRDLDQRY
1060 1070 1080 1090
NTILQMYGEK AEEAEELRLD LEDVKNMYKT QIDELLRQRL S
Length:1,091
Mass (Da):121,803
Last modified:July 27, 2011 - v2
Checksum:iD208A815FF740CF1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJK7D6RJK7_MOUSE
TATA element modulatory factor
Tmf1
784Annotation score:

Sequence cautioni

The sequence BAE26035 differs from that shown. Reason: Frameshift at position 44.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106A → V in AAI50932 (PubMed:15489334).Curated1
Sequence conflicti144V → A in AAI50932 (PubMed:15489334).Curated1
Sequence conflicti161S → P in AAI50932 (PubMed:15489334).Curated1
Sequence conflicti203T → S in AAI50932 (PubMed:15489334).Curated1
Sequence conflicti439P → L in AAI50932 (PubMed:15489334).Curated1
Sequence conflicti871L → I in AAI50932 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155724 Genomic DNA No translation available.
BC150931 mRNA Translation: AAI50932.1
AK144898 mRNA Translation: BAE26120.1
AK144729 mRNA Translation: BAE26035.1 Frameshift.
CCDSiCCDS39575.1
RefSeqiNP_001074580.1, NM_001081111.2
UniGeneiMm.30893

Genome annotation databases

EnsembliENSMUST00000095664; ENSMUSP00000093325; ENSMUSG00000030059
GeneIDi232286
KEGGimmu:232286
UCSCiuc009dak.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155724 Genomic DNA No translation available.
BC150931 mRNA Translation: AAI50932.1
AK144898 mRNA Translation: BAE26120.1
AK144729 mRNA Translation: BAE26035.1 Frameshift.
CCDSiCCDS39575.1
RefSeqiNP_001074580.1, NM_001081111.2
UniGeneiMm.30893

3D structure databases

SMRiB9EKI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231235, 4 interactors
IntActiB9EKI3, 1 interactor
STRINGi10090.ENSMUSP00000093325

PTM databases

iPTMnetiB9EKI3
PhosphoSitePlusiB9EKI3

Proteomic databases

EPDiB9EKI3
MaxQBiB9EKI3
PaxDbiB9EKI3
PeptideAtlasiB9EKI3
PRIDEiB9EKI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095664; ENSMUSP00000093325; ENSMUSG00000030059
GeneIDi232286
KEGGimmu:232286
UCSCiuc009dak.2 mouse

Organism-specific databases

CTDi7110
MGIiMGI:2684999 Tmf1

Phylogenomic databases

eggNOGiENOG410IGA0 Eukaryota
ENOG410YE9Z LUCA
GeneTreeiENSGT00390000010697
HOGENOMiHOG000154639
InParanoidiB9EKI3
KOiK20286
OMAiGEISHLQ
OrthoDBiEOG091G01F7
TreeFamiTF329420

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

PROiPR:B9EKI3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030059 Expressed in 232 organ(s), highest expression level in testis
ExpressionAtlasiB9EKI3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR022092 TMF_DNA-bd
IPR022091 TMF_TATA-bd
PfamiView protein in Pfam
PF12329 TMF_DNA_bd, 1 hit
PF12325 TMF_TATA_bd, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMF1_MOUSE
AccessioniPrimary (citable) accession number: B9EKI3
Secondary accession number(s): E9QPJ3, Q3UMH8, Q3UMR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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