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Entry version 64 (07 Oct 2020)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

TANC1 protein

Gene

TANC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TANC1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TANC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670838

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B9EK39

PRoteomics IDEntifications database

More...
PRIDEi
B9EK39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B9EK39, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini888 – 1262ANK_REP_REGIONInterPro annotationAdd BLAST375
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati959 – 991ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1070 – 1102ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1103 – 1135ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1136 – 1168ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1169 – 1201ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1202 – 1234ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1281 – 1361TPR_REGIONInterPro annotationAdd BLAST81
Repeati1281 – 1314TPRPROSITE-ProRule annotationAdd BLAST34
Repeati1328 – 1361TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni63 – 99DisorderedSequence analysisAdd BLAST37
Regioni256 – 310DisorderedSequence analysisAdd BLAST55
Regioni431 – 478DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21PolyampholyteSequence analysisAdd BLAST21
Compositional biasi33 – 47PolarSequence analysisAdd BLAST15
Compositional biasi63 – 81PolarSequence analysisAdd BLAST19
Compositional biasi272 – 286PolarSequence analysisAdd BLAST15
Compositional biasi295 – 310PolarSequence analysisAdd BLAST16
Compositional biasi431 – 477PolarSequence analysisAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 10 hits
SM00028, TPR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9EK39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKAVLKKSR EGGKGGKKEA GSDFGPETSS VLHLDHSADS PVSSLPTAED
60 70 80 90 100
TYRVSLAKGV SMSLPSSPLL PRQSHLVQSR VNKKSPGPVR KPKYVESPRV
110 120 130 140 150
PGDAVIMPFR EVAKPTEPDE HAKADNEPSC SPAAQELLTR LGFLLGEGIP
160 170 180 190 200
SATHITIEDK NETMCTALSQ GISPCSTLTS STASPSTDSP CSTLNSCVSK
210 220 230 240 250
TAANKSPCET ISSPSSTLES KDSGIIATIT SSSENDDRSG SSLEWNKDGS
260 270 280 290 300
LRLGVQKGVL HDRRADNCSP VAEEETTGSA ESTLPKAESS AGDGPVPYSQ
310 320 330 340 350
GSSSLIMPRP NSVAATSSTK LEDLSYLDGQ RNAPLRTSIR LPWHNTAGAR
360 370 380 390 400
FAPYKPQDIL LKPLLFEVPS ITTDSVFVGR DWLFHQIEEN LRNTELAENR
410 420 430 440 450
GAVVVGNVGF GKTAIISKLV ALSCHGSRMR QIASNSPGSS PKTSDPTQDL
460 470 480 490 500
HFTPLLSPSS STSASSTAKT PLGSISAENQ RPREDAVKYL ASKVVAYHYC
510 520 530 540 550
QADNTYTCLV PEFVHSIAAL LCRSHQLAAY RDLLIKEPQL QSMLSLRSCV
560 570 580 590 600
QDPVAAFKRG VLEPLTNLRN EQKIPEEEYI ILIDGLNEAE FHKPDYGDTL
610 620 630 640 650
SSFITKIISK FPAWLKLIVT VRANFQEIIS ALPFVKLSLD DFPDNKDIHS
660 670 680 690 700
DLHAYVQHRV HSSQDILSNI SLNGKADATL IGKVSSHLVL RSLGSYLYLK
710 720 730 740 750
LTLDLFQRGH LVIKSASYKV VPVSLSELYL LQCNMKFMTQ SAFERALPIL
760 770 780 790 800
NVALASLHPM TDEQIFQAIN AGHIQGEQGW EDFQQRMDAL SCFLIKRRDK
810 820 830 840 850
TRMFCHPSFR EWLVWRADGE NTAFLCEPRN GHALLAFMFS RQEGKLNRQQ
860 870 880 890 900
TMELGHHILK AHIFKGLSKK TGISSSHLQA LWIGYSTEGL SAALASLRNL
910 920 930 940 950
YTPNVKVSRL LILGGANVNY RTEVLNNAPI LCVQSHLGHE EVVTLLLEFG
960 970 980 990 1000
ACLDGTSENG MTALCYAAAA GHMKLVCLLT KKGVRVDHLD KKGQCALVHS
1010 1020 1030 1040 1050
ALRGHGDILQ YLLTCEWSPG PPQPGTLRKS HALQQALTAA ASMGHSSVVQ
1060 1070 1080 1090 1100
CLLGMEKEHE VEVNGTDTLW GETALTAAAG RGKLEVCELL LGHGAAVSRT
1110 1120 1130 1140 1150
NRRGVPPLFC AARQGHWQIV RLLLERGCDV NLSDKQGRTP LMVAACEGHL
1160 1170 1180 1190 1200
STVEFLLSKG AALSSLDKEG LSALSWACLK GHRAVVQYLV EEGAAIDQTD
1210 1220 1230 1240 1250
KNGRTPLDLA AFYGDAETVL YLVEKGAVIE HVDHSGMRPL DRAIGCRNTS
1260 1270 1280 1290 1300
VVVALLRKGA KLGNAAWAMA TSKPDILIIL LQKLMEEGNV MYKKGKMKEA
1310 1320 1330 1340 1350
AQRYQYALRK FPREGFGEDM RPFNELRVSL YLNLSRCRRK TNDFGMAEEF
1360 1370 1380 1390
ASKALELKPK SYEAFYARAR AKRNSRYRNS WQLWLTCKRL
Length:1,390
Mass (Da):152,147
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D7DC5CC8A78B9C1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC150597 mRNA Translation: AAI50598.1

NCBI Reference Sequences

More...
RefSeqi
NP_001139381.1, NM_001145909.1
NP_203752.2, NM_033394.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85461

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85461

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150597 mRNA Translation: AAI50598.1
RefSeqiNP_001139381.1, NM_001145909.1
NP_203752.2, NM_033394.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB9EK39
PRIDEiB9EK39

Genome annotation databases

GeneIDi85461
KEGGihsa:85461

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85461
PharmGKBiPA142670838

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
85461, 2 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TANC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85461

Gene expression databases

GenevisibleiB9EK39, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF12796, Ank_2, 3 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 10 hits
SM00028, TPR, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 6 hits
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9EK39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9EK39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: October 7, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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