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Protein

GREB1-like protein

Gene

Greb1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in early metanephros and genital development.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
GREB1-like protein
Gene namesi
Name:Greb1l
Synonyms:Kiaa4095
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3576497 Greb1l

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1832 – 1852HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal at the homozygous state. At 13.5 dpc, all homozygous embryos are significantly smaller compared to wild-type and heterozygous littermates and present with exencephaly. Male and female embryos lack kidney and show absence of Wolffian and Muellerian ducts, respectively. However, mesonephric tubules are consistently observed. Some potential remnants of ureteric bud are present in most mutant embryos. In male mutant embryos, the gonads are severely affected, being small and with poorly organized sex-cords compared to wild-type littermates. Mutant embryos also show cardiac morphogenesis defects with superimposed ventricles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161271 – 1913GREB1-like proteinAdd BLAST1913

Proteomic databases

PaxDbiB9EJV3
PRIDEiB9EJV3

PTM databases

iPTMnetiB9EJV3
PhosphoSitePlusiB9EJV3

Expressioni

Developmental stagei

At 15.5 dpc, expressed in kidney, ureter and bladder (PubMed:29100090). At 16.0 dpc, strong expression in the liver, thymus, intestine, kidney, and brain. In the brain, high levels in the ventricular zone and in the neopallial cortex. In the kidney, highest levels in the nephrogenic zone located in the cortical region of the kidney. Also observed in epithelial cells of the differentiating renal tubules. At P0, strong expression in the nephrogenic zone (PubMed:29100091).2 Publications

Gene expression databases

BgeeiENSMUSG00000042942 Expressed in 186 organ(s), highest expression level in presomitic mesoderm
ExpressionAtlasiB9EJV3 baseline and differential
GenevisibleiB9EJV3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049003

Structurei

3D structure databases

SMRiB9EJV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1120 – 1200Ser-richAdd BLAST81

Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9T Eukaryota
ENOG410Z1PN LUCA
GeneTreeiENSGT00390000008041
HOGENOMiHOG000090251
HOVERGENiHBG107963
InParanoidiB9EJV3
OMAiAHNAFHH
OrthoDBiEOG091G009I
PhylomeDBiB9EJV3
TreeFamiTF329531

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
IPR024840 GREB1-like
PANTHERiPTHR15720 PTHR15720, 1 hit
PTHR15720:SF12 PTHR15720:SF12, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B9EJV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSYAGQLK SARFEEALHN SIEASLRCST AVPRPIFSQL YLDPDQHPFS
60 70 80 90 100
TADVKPKVED LDKDLVHPYT QNGSVDFSHN VAMNEMEDDE DEEEMSDSNS
110 120 130 140 150
PPIPYSQKPA PEGSCTTDGF CQAGKDLRLV SLCMEQIDIP AGFLLVGAKS
160 170 180 190 200
PNLPEHILVC AVDKRFLPDD HGKNALLGFS GNCIGCGERG FRYFTEFSNH
210 220 230 240 250
INLKLTTQPK KQKHLKYYLV RTSQGVLSKG PLICWKECRS RQSSALCHST
260 270 280 290 300
KPISSVSSAV APENGTANGY KAGFTVTEAA NGTSGHGGKS SSCSSTPSRP
310 320 330 340 350
GNYSLSPRPT FTSVDQANMF ISGPPKKRHR GWYPGSPVSQ SALVVPAPTV
360 370 380 390 400
RPLSRTEPLL STPVPQTPLT GILQPRPVLA GETVIVPENL LSNSGVRPVI
410 420 430 440 450
LIGYGTLPYF YGNVGDIVVS PLLVNCYKIP QLENKDLEQL GLTSTHLLSV
460 470 480 490 500
ENMILLTIQY LVRLGPDQIP LREEFEQIML TAMQEFSVRE RALPLGAPCA
510 520 530 540 550
PMSPAQLPWL ARLAASVSQD LVHVIVTQNS LAEGISETLR LLSEMKHYQR
560 570 580 590 600
LPDYVVAICA SKIRGNEFCV VVLGQHQSRA LAESMLTTSE FLKEISYELI
610 620 630 640 650
TGKVSFLASH FKTTSLGDDL DKLLEKMQQR RGDSVVTPFN GDLDECVSPQ
660 670 680 690 700
EAAAMIPTQN LDVDNETFQI YQPQLTVARR LLSQVCAIAD SGSQSLDLGH
710 720 730 740 750
FSKVDFIIIV PRSEVLVQQT LQRVRQSGVL VDLGLEESGL AHQRAERYVV
760 770 780 790 800
RLDNEIQSKF EVFMRRVKQN PYTLFVLVHD NSHVELTSVI SGSLSHGEPT
810 820 830 840 850
HGLADRVINC REVLEAFNLL VLQVSSFPYT LQTQQSRISS SNEVHWIQLD
860 870 880 890 900
TMEDAGCEKL YFGLDEYSKS LQWGITSPLL RCDETFEKMV STLLERYPRL
910 920 930 940 950
HSMVVRCYLL IQQYSEALMA LTTMASLRDH STPETLSIMD DLITSPGKNK
960 970 980 990 1000
SGKGHMLVIR VPSVQLAMLA KERLQEVRDK LGLQYRFEII LGSPASELTV
1010 1020 1030 1040 1050
ETHFVTRLKT WRGNDQDEWI PRTYQDLEGL PCIVILTGKD PLGETFPRSL
1060 1070 1080 1090 1100
KYCDLRLIDS SYLTRTALEQ EVGLACCYVS KEVIRGPAAA LDLSAKEAER
1110 1120 1130 1140 1150
VPASENDSEE LLIDLERPQS NSSAVTGTSG SIMENGVSSS STAGKPQQQL
1160 1170 1180 1190 1200
LTPTSSIRLD EGVSASTAVV GEILKQECDS LDPPMASSTT SKPSSSSSSS
1210 1220 1230 1240 1250
AQALAWSRQP RGLHTALPPV IILSKAAYSL LGSQKGGRLP SSSSLLPHAD
1260 1270 1280 1290 1300
VAWVSSLRPG LHKDMSSEEQ SLYYRQWTSA RQHHADYSNQ PDPISGARTL
1310 1320 1330 1340 1350
HPRRLLLTGP PQVGKTGSYL QFLRILFRML IRLLEVDVYN EEEINTDHSD
1360 1370 1380 1390 1400
DSELSQSEGE PWPDIETFSK MPFDVSVHDP KYRLMSLVYS EKLAGIKQEV
1410 1420 1430 1440 1450
IKEYKVEEPR QRETMSMMLT QYAAYNTFHH CEQCQQYMAF TPASQMSDST
1460 1470 1480 1490 1500
LHAFTFSSSM LGEEVQLYFI IPKSKESHFV FSKQGRHLES MRLPLVSDKN
1510 1520 1530 1540 1550
LNAVKSPIFT PSSGRHEHGL LNLFHAMEGI SHLHLLVVKE YEMPLYRKYW
1560 1570 1580 1590 1600
PNHIMLVLPG MFNNAGVGAA RFLIKELSYH NLELERNRLE ELGVKRQCVW
1610 1620 1630 1640 1650
PFIVVMDDSC VLWNIHSVQE QTSQPTEAGI SSKNVSLKSV LQHIEATPKI
1660 1670 1680 1690 1700
IHYAILGIQK WNSKLTSQSL KAPFSRCHVH DFILLNIDLT QNVQYDFNRY
1710 1720 1730 1740 1750
FCEDVDFNLR TNSSGLLICR FNNFSLMKKH VQVGGQRDFI IKPKLMVSEN
1760 1770 1780 1790 1800
VVPILPLQYV CAPDSEHTLL AAPAQFLLEK FLQHASYKLF PKAIHNFKSP
1810 1820 1830 1840 1850
VLAIDCYLNI GQEVAICYVS SRPHSSNVNC EGVFFSGLLL YLCDSFVGAD
1860 1870 1880 1890 1900
LLKKFKFLKG ATLCVICQDR SSLRQTIVRL ELEDEWQFRL RDEFQTANSS
1910
DDKPLYFLTG RHV
Length:1,913
Mass (Da):213,628
Last modified:March 24, 2009 - v1
Checksum:i531E8AF95AD9ECFC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYH8G3UYH8_MOUSE
GREB1-like protein
Greb1l
991Annotation score:
G3UZ23G3UZ23_MOUSE
GREB1-like protein
Greb1l
129Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102441 Genomic DNA No translation available.
AC124740 Genomic DNA No translation available.
BC147570 mRNA Translation: AAI47571.1
AK220484 mRNA Translation: BAD90285.1
CCDSiCCDS37736.1
RefSeqiNP_001077097.1, NM_001083628.1
UniGeneiMm.261535

Genome annotation databases

EnsembliENSMUST00000048977; ENSMUSP00000049003; ENSMUSG00000042942
GeneIDi381157
KEGGimmu:381157
UCSCiuc008eat.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102441 Genomic DNA No translation available.
AC124740 Genomic DNA No translation available.
BC147570 mRNA Translation: AAI47571.1
AK220484 mRNA Translation: BAD90285.1
CCDSiCCDS37736.1
RefSeqiNP_001077097.1, NM_001083628.1
UniGeneiMm.261535

3D structure databases

SMRiB9EJV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049003

PTM databases

iPTMnetiB9EJV3
PhosphoSitePlusiB9EJV3

Proteomic databases

PaxDbiB9EJV3
PRIDEiB9EJV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048977; ENSMUSP00000049003; ENSMUSG00000042942
GeneIDi381157
KEGGimmu:381157
UCSCiuc008eat.1 mouse

Organism-specific databases

CTDi80000
MGIiMGI:3576497 Greb1l
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IF9T Eukaryota
ENOG410Z1PN LUCA
GeneTreeiENSGT00390000008041
HOGENOMiHOG000090251
HOVERGENiHBG107963
InParanoidiB9EJV3
OMAiAHNAFHH
OrthoDBiEOG091G009I
PhylomeDBiB9EJV3
TreeFamiTF329531

Miscellaneous databases

PROiPR:B9EJV3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042942 Expressed in 186 organ(s), highest expression level in presomitic mesoderm
ExpressionAtlasiB9EJV3 baseline and differential
GenevisibleiB9EJV3 MM

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
IPR024840 GREB1-like
PANTHERiPTHR15720 PTHR15720, 1 hit
PTHR15720:SF12 PTHR15720:SF12, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGRB1L_MOUSE
AccessioniPrimary (citable) accession number: B9EJV3
Secondary accession number(s): Q5DTN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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