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UniProtKB - B9EJG8 (T150C_HUMAN)

Entry version 73 (13 Feb 2019)
Sequence version 1 (24 Mar 2009)
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Protein

Transmembrane protein 150C

Gene

TMEM150C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.By similarity

Miscellaneous

Tentonin comes from the Greek "tentono" meaning to stretch.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cellular response to mechanical stimulus Source: UniProtKB
  • proprioception Source: UniProtKB
  • regulation of autophagy Source: GO_Central
View the complete GO annotation on QuickGO ...

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.113.1.1 the tentonin or tmem150 (tmem150) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 150C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM150C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000249242.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:37263 TMEM150C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_B9EJG8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicCurated9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 64ExtracellularCuratedAdd BLAST34
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 97CytoplasmicCuratedAdd BLAST12
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 130ExtracellularCuratedAdd BLAST12
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 168CytoplasmicCuratedAdd BLAST17
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 192ExtracellularCurated3
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 249CytoplasmicBy similarityAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000249242

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165664735

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM150C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003950321 – 249Transmembrane protein 150CAdd BLAST249

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		B9EJG8

PRoteomics IDEntifications database

More...PRIDEi		B9EJG8

ProteomicsDB human proteome resource

More...ProteomicsDBi		7533
7534 [B9EJG8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		B9EJG8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		B9EJG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000249242 Expressed in 207 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B9EJG8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B9EJG8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA052921

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000403438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		B9EJG8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DRAM/TMEM150 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4320 Eukaryota
ENOG4111KNB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000273877

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG062574

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B9EJG8

KEGG Orthology (KO)

More...KOi		K21846

Identification of Orthologs from Complete Genome Data

More...OMAi		PPYISIA

Database of Orthologous Groups

More...OrthoDBi		1199230at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		B9EJG8

TreeFam database of animal gene trees

More...TreeFami		TF314508

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019402 Frag1/DRAM/Sfk1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10277 Frag1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B9EJG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGKKCSVWM FLPLVFTLFT SAGLWIVYFI AVEDDKILPL NSAERKPGVK 
        60         70         80         90        100
HAPYISIAGD DPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN 
       110        120        130        140        150
ISGLVALCLA SFGMTLLGNF QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL 
       160        170        180        190        200
TLKVNIKNEG RRVGIPRVIL SASITLCVVL YFILMAQSIH MYAARVQWGL 
       210        220        230        240 
VMCFLSYFGT FAVEFRHYRY EIVCSEYQEN FLSFSESLSE ASEYQTDQV
Length:249
Mass (Da):27,887
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4729E0B10C954B4
GO
Isoform 2 (identifier: B9EJG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-210: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,111
Checksum:i65920852A2CDDC80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDW6D6RDW6_HUMAN
Transmembrane protein 150C
TMEM150C
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAQ9D6RAQ9_HUMAN
Transmembrane protein 150C
TMEM150C
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAH12581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46K → R in BAH13412 (PubMed:14702039).Curated1
Sequence conflicti101I → V in BAH13178 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039350142 – 210Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK297434 mRNA Translation: BAH12581.1 Different initiation.
AK297512 mRNA Translation: BAH12599.1
AK299942 mRNA Translation: BAH13178.1
AK301116 mRNA Translation: BAH13412.1
AC067942 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05896.1
BC147019 mRNA Translation: AAI47020.1
BC147027 mRNA Translation: AAI47028.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47087.1 [B9EJG8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001073975.1, NM_001080506.1 [B9EJG8-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.507676
Hs.733551

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000449862; ENSP00000403438; ENSG00000249242 [B9EJG8-1]
ENST00000515780; ENSP00000420919; ENSG00000249242 [B9EJG8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		441027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:441027

UCSC genome browser

More...UCSCi		uc003hmy.2 human [B9EJG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297434 mRNA Translation: BAH12581.1 Different initiation.
AK297512 mRNA Translation: BAH12599.1
AK299942 mRNA Translation: BAH13178.1
AK301116 mRNA Translation: BAH13412.1
AC067942 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05896.1
BC147019 mRNA Translation: AAI47020.1
BC147027 mRNA Translation: AAI47028.1
CCDSiCCDS47087.1 [B9EJG8-1]
RefSeqiNP_001073975.1, NM_001080506.1 [B9EJG8-1]
UniGeneiHs.507676
Hs.733551

3D structure databases

ProteinModelPortaliB9EJG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000403438

Protein family/group databases

TCDBi8.A.113.1.1 the tentonin or tmem150 (tmem150) family

PTM databases

iPTMnetiB9EJG8
PhosphoSitePlusiB9EJG8

Polymorphism and mutation databases

BioMutaiTMEM150C

Proteomic databases

PaxDbiB9EJG8
PRIDEiB9EJG8
ProteomicsDBi7533
7534 [B9EJG8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449862; ENSP00000403438; ENSG00000249242 [B9EJG8-1]
ENST00000515780; ENSP00000420919; ENSG00000249242 [B9EJG8-1]
GeneIDi441027
KEGGihsa:441027
UCSCiuc003hmy.2 human [B9EJG8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		441027
EuPathDBiHostDB:ENSG00000249242.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM150C
HGNCiHGNC:37263 TMEM150C
HPAiHPA052921
neXtProtiNX_B9EJG8
OpenTargetsiENSG00000249242
PharmGKBiPA165664735

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4320 Eukaryota
ENOG4111KNB LUCA
GeneTreeiENSGT00940000154324
HOGENOMiHOG000273877
HOVERGENiHBG062574
InParanoidiB9EJG8
KOiK21846
OMAiPPYISIA
OrthoDBi1199230at2759
PhylomeDBiB9EJG8
TreeFamiTF314508

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM150C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		441027

Protein Ontology

More...PROi		PR:B9EJG8

Gene expression databases

BgeeiENSG00000249242 Expressed in 207 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiB9EJG8 baseline and differential
GenevisibleiB9EJG8 HS

Family and domain databases

InterProiView protein in InterPro
IPR019402 Frag1/DRAM/Sfk1
PfamiView protein in Pfam
PF10277 Frag1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT150C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9EJG8
Secondary accession number(s): B7Z4J5
, B7Z4L3, B7Z692, B7Z6X6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 24, 2009
Last modified: February 13, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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