UniProtKB - B9EJG8 (T150C_HUMAN)
Protein
Transmembrane protein 150C
Gene
TMEM150C
Organism
Homo sapiens (Human)
Status
Functioni
Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.By similarity
Miscellaneous
Tentonin comes from the Greek "tentono" meaning to stretch.By similarity
GO - Molecular functioni
- mechanosensitive ion channel activity Source: Ensembl
GO - Biological processi
- cellular response to mechanical stimulus Source: UniProtKB
- proprioception Source: UniProtKB
- regulation of autophagy Source: GO_Central
Protein family/group databases
TCDBi | 8.A.113.1.1 the tentonin or tmem150 (tmem150) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 150C |
Gene namesi | Name:TMEM150C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000249242.7 |
HGNCi | HGNC:37263 TMEM150C |
neXtProti | NX_B9EJG8 |
Subcellular locationi
Lysosome
- Lysosome membrane 1 Publication; Multi-pass membrane protein Curated
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530).1 Publication
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicCurated | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 64 | ExtracellularCuratedAdd BLAST | 34 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 97 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 130 | ExtracellularCuratedAdd BLAST | 12 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 168 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 169 – 189 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 190 – 192 | ExtracellularCurated | 3 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 249 | CytoplasmicBy similarityAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, Lysosome, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000249242 |
PharmGKBi | PA165664735 |
Polymorphism and mutation databases
BioMutai | TMEM150C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395032 | 1 – 249 | Transmembrane protein 150CAdd BLAST | 249 |
Proteomic databases
PaxDbi | B9EJG8 |
PRIDEi | B9EJG8 |
ProteomicsDBi | 7533 7534 [B9EJG8-2] |
PTM databases
iPTMneti | B9EJG8 |
PhosphoSitePlusi | B9EJG8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000249242 Expressed in 207 organ(s), highest expression level in corpus epididymis |
ExpressionAtlasi | B9EJG8 baseline and differential |
Genevisiblei | B9EJG8 HS |
Organism-specific databases
HPAi | HPA052921 |
Family & Domainsi
Sequence similaritiesi
Belongs to the DRAM/TMEM150 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4320 Eukaryota ENOG4111KNB LUCA |
GeneTreei | ENSGT00940000154324 |
HOGENOMi | HOG000273877 |
HOVERGENi | HBG062574 |
InParanoidi | B9EJG8 |
KOi | K21846 |
OMAi | PPYISIA |
OrthoDBi | 1199230at2759 |
PhylomeDBi | B9EJG8 |
TreeFami | TF314508 |
Family and domain databases
InterProi | View protein in InterPro IPR019402 Frag1/DRAM/Sfk1 |
Pfami | View protein in Pfam PF10277 Frag1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: B9EJG8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDGKKCSVWM FLPLVFTLFT SAGLWIVYFI AVEDDKILPL NSAERKPGVK
60 70 80 90 100
HAPYISIAGD DPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN
110 120 130 140 150
ISGLVALCLA SFGMTLLGNF QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL
160 170 180 190 200
TLKVNIKNEG RRVGIPRVIL SASITLCVVL YFILMAQSIH MYAARVQWGL
210 220 230 240
VMCFLSYFGT FAVEFRHYRY EIVCSEYQEN FLSFSESLSE ASEYQTDQV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RDW6 | D6RDW6_HUMAN | Transmembrane protein 150C | TMEM150C | 67 | Annotation score: | ||
D6RAQ9 | D6RAQ9_HUMAN | Transmembrane protein 150C | TMEM150C | 120 | Annotation score: |
Sequence cautioni
The sequence BAH12581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | K → R in BAH13412 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 101 | I → V in BAH13178 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039350 | 142 – 210 | Missing in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297434 mRNA Translation: BAH12581.1 Different initiation. AK297512 mRNA Translation: BAH12599.1 AK299942 mRNA Translation: BAH13178.1 AK301116 mRNA Translation: BAH13412.1 AC067942 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05896.1 BC147019 mRNA Translation: AAI47020.1 BC147027 mRNA Translation: AAI47028.1 |
CCDSi | CCDS47087.1 [B9EJG8-1] |
RefSeqi | NP_001073975.1, NM_001080506.1 [B9EJG8-1] |
UniGenei | Hs.507676 Hs.733551 |
Genome annotation databases
Ensembli | ENST00000449862; ENSP00000403438; ENSG00000249242 [B9EJG8-1] ENST00000515780; ENSP00000420919; ENSG00000249242 [B9EJG8-1] |
GeneIDi | 441027 |
KEGGi | hsa:441027 |
UCSCi | uc003hmy.2 human [B9EJG8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297434 mRNA Translation: BAH12581.1 Different initiation. AK297512 mRNA Translation: BAH12599.1 AK299942 mRNA Translation: BAH13178.1 AK301116 mRNA Translation: BAH13412.1 AC067942 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05896.1 BC147019 mRNA Translation: AAI47020.1 BC147027 mRNA Translation: AAI47028.1 |
CCDSi | CCDS47087.1 [B9EJG8-1] |
RefSeqi | NP_001073975.1, NM_001080506.1 [B9EJG8-1] |
UniGenei | Hs.507676 Hs.733551 |
3D structure databases
ProteinModelPortali | B9EJG8 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000403438 |
Protein family/group databases
TCDBi | 8.A.113.1.1 the tentonin or tmem150 (tmem150) family |
PTM databases
iPTMneti | B9EJG8 |
PhosphoSitePlusi | B9EJG8 |
Polymorphism and mutation databases
BioMutai | TMEM150C |
Proteomic databases
PaxDbi | B9EJG8 |
PRIDEi | B9EJG8 |
ProteomicsDBi | 7533 7534 [B9EJG8-2] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000449862; ENSP00000403438; ENSG00000249242 [B9EJG8-1] ENST00000515780; ENSP00000420919; ENSG00000249242 [B9EJG8-1] |
GeneIDi | 441027 |
KEGGi | hsa:441027 |
UCSCi | uc003hmy.2 human [B9EJG8-1] |
Organism-specific databases
CTDi | 441027 |
EuPathDBi | HostDB:ENSG00000249242.7 |
GeneCardsi | TMEM150C |
HGNCi | HGNC:37263 TMEM150C |
HPAi | HPA052921 |
neXtProti | NX_B9EJG8 |
OpenTargetsi | ENSG00000249242 |
PharmGKBi | PA165664735 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4320 Eukaryota ENOG4111KNB LUCA |
GeneTreei | ENSGT00940000154324 |
HOGENOMi | HOG000273877 |
HOVERGENi | HBG062574 |
InParanoidi | B9EJG8 |
KOi | K21846 |
OMAi | PPYISIA |
OrthoDBi | 1199230at2759 |
PhylomeDBi | B9EJG8 |
TreeFami | TF314508 |
Miscellaneous databases
ChiTaRSi | TMEM150C human |
GenomeRNAii | 441027 |
PROi | PR:B9EJG8 |
Gene expression databases
Bgeei | ENSG00000249242 Expressed in 207 organ(s), highest expression level in corpus epididymis |
ExpressionAtlasi | B9EJG8 baseline and differential |
Genevisiblei | B9EJG8 HS |
Family and domain databases
InterProi | View protein in InterPro IPR019402 Frag1/DRAM/Sfk1 |
Pfami | View protein in Pfam PF10277 Frag1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | T150C_HUMAN | |
Accessioni | B9EJG8Primary (citable) accession number: B9EJG8 Secondary accession number(s): B7Z4J5 B7Z6X6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | March 24, 2009 | |
Last modified: | February 13, 2019 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM