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Entry version 67 (29 Sep 2021)
Sequence version 1 (24 Mar 2009)
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Protein
Submitted name:

Collagen, type XII, alpha 1

Gene

COL12A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type XII, alpha 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL12A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500288098624 – 1899Sequence analysisAdd BLAST1876

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B9EJB8

PRoteomics IDEntifications database

More...
PRIDEi
B9EJB8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 207VWFAInterPro annotationAdd BLAST173
Domaini223 – 312Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini313 – 403Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini404 – 494Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini495 – 590Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini591 – 685Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini772 – 862Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini863 – 953Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini954 – 1042Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1043 – 1130Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1159 – 1332VWFAInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1119 – 1148DisorderedSequence analysisAdd BLAST30
Regioni1579 – 1732DisorderedSequence analysisAdd BLAST154
Regioni1765 – 1899DisorderedSequence analysisAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1133 – 1148Pro residuesSequence analysisAdd BLAST16
Compositional biasi1614 – 1633Pro residuesSequence analysisAdd BLAST20
Compositional biasi1660 – 1674Pro residuesSequence analysisAdd BLAST15
Compositional biasi1776 – 1790Pro residuesSequence analysisAdd BLAST15
Compositional biasi1854 – 1872Pro residuesSequence analysisAdd BLAST19
Compositional biasi1884 – 1899Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

CollagenImportedARBA annotation, SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 10 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR001791, Laminin_G
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 4 hits
PF00041, fn3, 10 hits
PF00092, VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 10 hits
SM00210, TSPN, 1 hit
SM00327, VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 6 hits
SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 9 hits
PS50234, VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9EJB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRLPPALA ALGAALLLSS IEAEGMECLT RAEADIVLLV DGSWSIGRAN
60 70 80 90 100
FRTVRSFISR IVEVFDIGPK RVQIALAQYS GDPRTEWQLN AHRDKKSLLQ
110 120 130 140 150
AVANLPYKGG NTLTGMALNF IRQQNFRTQA GMRPRARKIG VLITDGKSQD
160 170 180 190 200
DVEAPSKKLK DEGVELFAIG IKNADEVELK MIATDPDDTH AYNVADFESL
210 220 230 240 250
SRIVDDLTIN LCNSVKGPGD LEAPSNLVIS ERTHRSFRVS WTPPSDSVDR
260 270 280 290 300
YKVEYYPVSG GKRQEFYVSR METSTVLKDL KPETEYVVNV YSVVEDEYSE
310 320 330 340 350
PLKGTEKTLP VPVVSLNIYD VGPTTMHVQW QPVGGATGYI LSYKPVKDTE
360 370 380 390 400
PTRPKEVRLG PTVNDMQLTD LVPNTEYAVT VQAVLHDLTS EPVTVREVTL
410 420 430 440 450
PLPRPQDLKL RDVTHSTMNV FWEPVPGKVR KYIVRYKTPE EDVKEVEVDR
460 470 480 490 500
SETSTSLKDL FSQTLYTVSV SAVHDEGESP PVTAQETTRP VPAPTNLKIT
510 520 530 540 550
EVTSEGFRGT WDHGASDVSL YRITWAPFGS SDKMETILNG DENTLVFENL
560 570 580 590 600
NPNTIYEVSI TAIYPDESES DDLIGSERTL PILTTQAPKS GPRNLQVYNA
610 620 630 640 650
TSNSLTVKWD PASGRVQKYR ITYQPSTGEG NEQTTTIGGR QNSVVLQKLK
660 670 680 690 700
PDTPYTITVS SLYPDGEGGR MTGRGKTKPL NTVRNLRVYD PSTSTLNVRW
710 720 730 740 750
DHAEGNPRQY KLFYAPAAGG PEELVPIPGN TNYAILRNLQ PDTSYTVTVV
760 770 780 790 800
PVYTEGDGGR TSDTGRTLMR GLARNVQVYN PTPNSLDVRW DPAPGPVLQY
810 820 830 840 850
RVVYSPVDGT RPSESIVVPG NTRMVHLERL IPDTLYSVNL VALYSDGEGN
860 870 880 890 900
PSPAQGRTLP RSGPRNLRVF GETTNSLSVA WDHADGPVQQ YRIIYSPTVG
910 920 930 940 950
DPIDEYTTVP GRRNNVILQP LQPDTPYKIT VIAVYEDGDG GHLTGNGRTV
960 970 980 990 1000
GLLPPQNIHI SDEWYTRFRV SWDPSPSPVL GYKIVYKPVG SNEPMEAFVG
1010 1020 1030 1040 1050
EMTSYTLHNL NPSTTYDVNV YAQYDSGLSV PLTDQGTTLY LNVTDLKTYQ
1060 1070 1080 1090 1100
IGWDTFCVKW SPHRAATSYR LKLSPADGTR GQEITVRGSE TSHCFTGLSP
1110 1120 1130 1140 1150
DTDYGVTVFV QTPNLEGPGV SVKEHTTVKP TEAPTEPPTP PPPPTIPPAR
1160 1170 1180 1190 1200
DVCKGAKADI VFLTDASWSI GDDNFNKVVK FIFNTVGGFD EISPAGIQVS
1210 1220 1230 1240 1250
FVQYSDEVKS EFKLNTYNDK ALALGALQNI RYRGGNTRTG KALTFIKEKV
1260 1270 1280 1290 1300
LTWESGMRKN VPKVLVVVTD GRSQDEVKKA ALVIQQSGFS VFVVGVADVD
1310 1320 1330 1340 1350
YNELANIASK PSERHVFIVD DFESFEKIED NLITFVCETA TSSCPLIYLD
1360 1370 1380 1390 1400
GYTSPGFKML EAYNLTEKNF ASVQGVSLES GSFPSYSAYR IQKNAFVNQP
1410 1420 1430 1440 1450
TADLHPNGLP PSYTIILLFR LLPETPSDPF AIWQITDRDY KPQVGVIADP
1460 1470 1480 1490 1500
SSKTLSFFNK DTRGEVQTVT FDTEEVKTLF YGSFHKVHIV VTSKSVKIYI
1510 1520 1530 1540 1550
DCYEIIEKDI KEAGNITTDG YEILGKLLKG ERKSAAFQIQ SFDIVCSPVW
1560 1570 1580 1590 1600
TSRDRCCDIP SRRDEGKCPA FPNSCTCTQD SVGPPGPPGP AGGPGAKGPR
1610 1620 1630 1640 1650
GERGISGAIG PPGPRGDIGP PGPQGPPGPQ GPNGLSIPGE QGRQGMKGDA
1660 1670 1680 1690 1700
GEPGLPGRTG TPGLPGPPGP MGPPGDRGFT GKDGAMGPRG PPGPPGSPGS
1710 1720 1730 1740 1750
PGVTGPSGKP GKPGDHGRPG PSGLKGEKGD RGDIASQNMM RAVARQVCEQ
1760 1770 1780 1790 1800
LISGQMNRFN QMLNQIPNDY QSSRNQPGPP GPPGPPGSAG ARGEPGPGGR
1810 1820 1830 1840 1850
PGFPGTPGMQ GPPGERGLPG EKGERGTGSS GPRGLPGPQG PQGESRTGPP
1860 1870 1880 1890
GSTGSRGPPG PPGRPGNSGI RGPPGPPGYC DSSQCASIPY NGQSYPGSG
Length:1,899
Mass (Da):205,552
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED4B9F5437E3BB25
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC146868 mRNA Translation: AAI46869.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146868 mRNA Translation: AAI46869.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB9EJB8
PRIDEiB9EJB8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL12A1, human

Family and domain databases

CDDicd00063, FN3, 10 hits
Gene3Di2.60.40.10, 10 hits
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR001791, Laminin_G
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF01391, Collagen, 4 hits
PF00041, fn3, 10 hits
PF00092, VWA, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 10 hits
SM00210, TSPN, 1 hit
SM00327, VWA, 2 hits
SUPFAMiSSF49265, SSF49265, 6 hits
SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 9 hits
PS50234, VWFA, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB9EJB8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9EJB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 29, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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