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UniProtKB - B9EJA2 (CTTB2_MOUSE)

Entry version 95 (25 May 2022)
Sequence version 2 (01 May 2013)
Previous versions | rss
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Protein

Cortactin-binding protein 2

Gene

Cttnbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cttnbp2
Synonyms:Kiaa1758
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1353467, Cttnbp2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000000416

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi540P → A: Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-543. 1 Publication1
Mutagenesisi543P → A: Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-540. 1 Publication1
Mutagenesisi599P → A: Reduced CTTN-binding; when associated with A-602. 1 Publication1
Mutagenesisi602P → A: Reduced CTTN-binding; when associated with A-599. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004221721 – 1648Cortactin-binding protein 2Add BLAST1648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei495Asymmetric dimethylarginineCombined sources1
Modified residuei1510PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		B9EJA2

PeptideAtlas

More...PeptideAtlasi		B9EJA2

PRoteomics IDEntifications database

More...PRIDEi		B9EJA2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		279291 [B9EJA2-1]
279292 [B9EJA2-2]
279293 [B9EJA2-3]
279294 [B9EJA2-4]
279295 [B9EJA2-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		B9EJA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		B9EJA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is predominantly expressed in brain (at protein level). In the brain, expressed at high levels in hypothalamus and striatum and at lower levels in cerebellum and cortex.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000000416, Expressed in Ammon's horn and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B9EJA2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B9EJA2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTTN/cortactin SH3 domain.

Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons (By similarity). Activation of glutamate receptors weakens the interaction with STRN and STRN4 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		205963, 27 interactors

Protein interaction database and analysis system

More...IntActi		B9EJA2, 4 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000088089

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		B9EJA2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		B9EJA2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B9EJA2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati699 – 729ANK 1Add BLAST31
Repeati733 – 762ANK 2Add BLAST30
Repeati766 – 795ANK 3Add BLAST30
Repeati799 – 828ANK 4Add BLAST30
Repeati832 – 861ANK 5Add BLAST30
Repeati901 – 931ANK 6Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni200 – 250DisorderedSequence analysisAdd BLAST51
Regioni322 – 439DisorderedSequence analysisAdd BLAST118
Regioni451 – 476DisorderedSequence analysisAdd BLAST26
Regioni492 – 608DisorderedSequence analysisAdd BLAST117
Regioni1438 – 1492DisorderedSequence analysisAdd BLAST55
Regioni1522 – 1648DisorderedSequence analysisAdd BLAST127

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 274Sequence analysisAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi200 – 216Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi229 – 250Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi331 – 345Polar residuesSequence analysisAdd BLAST15
Compositional biasi360 – 433Polar residuesSequence analysisAdd BLAST74
Compositional biasi452 – 476Polar residuesSequence analysisAdd BLAST25
Compositional biasi536 – 554Pro residuesSequence analysisAdd BLAST19
Compositional biasi576 – 597Polar residuesSequence analysisAdd BLAST22
Compositional biasi1474 – 1492Polar residuesSequence analysisAdd BLAST19
Compositional biasi1532 – 1547Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1548 – 1592Polar residuesSequence analysisAdd BLAST45
Compositional biasi1603 – 1631Polar residuesSequence analysisAdd BLAST29
Compositional biasi1632 – 1648Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWG2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_028813_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B9EJA2

Identification of Orthologs from Complete Genome Data

More...OMAi		MCPVEAL

Database of Orthologous Groups

More...OrthoDBi		264951at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		B9EJA2

TreeFam database of animal gene trees

More...TreeFami		TF325130

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF09727, CortBP2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B9EJA2-1) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-L

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDSASCEP DLSRTPGDTE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG 
        60         70         80         90        100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGPGDKEK 
       110        120        130        140        150
PVCTNPLSIL EAVMAHCRKM QERMSAQLVA AESRQKKLEM EKLQLQALEQ 
       160        170        180        190        200
EHKKLAAHLE EERGKNKHVV LMLVKECKQL SGKVVEEAQK LEEVMAQLEE 
       210        220        230        240        250
EKKKTSELEE QLSAEKQRSS GMEAQLEKQL SEFDTEREQL RAKLSREEAH 
       260        270        280        290        300
TTDLKEEIDK MKKMMEQMKK GSDGKPGLSL PRKTKDKRLA SISVATEGPV 
       310        320        330        340        350
TRSVACQTDV VTESTDPVKK LPLTVPIKPS TGSPLVPTNT KGNVGPSALL 
       360        370        380        390        400
IRPGIDRQSS HSDLGPSPPT ALPSSANRIE ENGPSTGNAP DLSNSTPSTP 
       410        420        430        440        450
SSTAPAAAQT PGTAPQNHSQ APTVHSLHSP CANTHPGLNP RIQAARFRFQ 
       460        470        480        490        500
GNANDPDQNG NNTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ 
       510        520        530        540        550
AGASSRLGVS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP PIPPKKPGLS 
       560        570        580        590        600
QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 
       610        620        630        640        650
LPPKPSIDLT VAPAGCPVSA LATSQVGAWP AGTPGLNQPA CSDSSLVIPA 
       660        670        680        690        700
TVAFCSSINP VSASSRSPGA SDSLLVAASG WSPSLTPLLM SGGPAPLAGR 
       710        720        730        740        750
PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV 
       760        770        780        790        800
RLLLNAEARV DAADKNGFTP LCVAAAQGHF ECIELLTAYN ANINHSAAGG 
       810        820        830        840        850
QTPLYLACKN GNKECIKLLL EAGTDRSIKT RDGWTPIHAA VDTGNVDSLK 
       860        870        880        890        900
LLMYHRVRAH GNSLSSEEPK SGLFSLNGGE SPTGPSKPVV PADLINHADK 
       910        920        930        940        950
EGWTAAHIAA SKGFKNCLEV LCRHGGLEPE RRDKCNRTVH DVATDDCKHL 
       960        970        980        990       1000
LENLNALKIP LRISVGEIQP SNDVSDDFEC EHTICTLNIR KQTSWEDFSK 
      1010       1020       1030       1040       1050
AVSQALTNHF QAISSDGWWS LEDGTFNNAT DSCIGLGTSS IRSIMLGSMP 
      1060       1070       1080       1090       1100
WSTGQSFSQS PWDFLKKKKV EQVLALLSGP QEGCLSSVTY ASMIPLQMLQ 
      1110       1120       1130       1140       1150
NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKYRQMAA GFPCEIVRAE 
      1160       1170       1180       1190       1200
VDSGFSKEQL VDVFIRNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 
      1210       1220       1230       1240       1250
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLVGTIAK ACLQGSDLLV 
      1260       1270       1280       1290       1300
QQHFRWVQLR WDCEPIQGLL QRFLRRKVVS KFRGQLPAPC DPVCKIVDWA 
      1310       1320       1330       1340       1350
LSVWRQLNSC LARLGTPEAL LGPKYFLSCP VVPGHAQATV KWMSKLWNAV 
      1360       1370       1380       1390       1400
IAPRVQEAIL SRASMNKQPG TGQTASKKYP SQGQQAVVRA ALSILLNKAV 
      1410       1420       1430       1440       1450
LHGCPLPRAE LDQQIADFKG GSFPLSIVSS YSKKKVESGA WRKVNTSPRK 
      1460       1470       1480       1490       1500
KPGHFSSPTW NKPDPKREGM RNKTIPHLNT NRNSSLSKQQ SLENDLSVTL 
      1510       1520       1530       1540       1550
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRD DLRKFDSSRT 
      1560       1570       1580       1590       1600
NPGTSAPLNL RTPVPQKEAS PPSSRQTAEC SNSKSKTEMG VSSVKSFLPV 
      1610       1620       1630       1640 
PRSKVAQCSQ NTKRNSSSSN TRQLEINNNS KEENWTLDKH EQVEKPNK
Length:1,648
Mass (Da):178,774
Last modified:May 1, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C7016DB9E61D7E0
GO
Isoform 2 (identifier: B9EJA2-2) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     626-630: VGAWP → AGHPP
     631-1648: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:630
Mass (Da):67,549
Checksum:iDAB904B4C2086805
GO
Isoform 3 (identifier: B9EJA2-3) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-intron

The sequence of this isoform differs from the canonical sequence as follows:
     681-710: WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQ → KGIEVFYPFVKNVPYSLTSLNFFYVVLKRF
     711-1648: Missing.

Note: Due to intron retention.Curated
Show »
Length:710
Mass (Da):75,900
Checksum:i9418424395611C6B
GO
Isoform 4 (identifier: B9EJA2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1568-1648: EASPPSSRQT...KHEQVEKPNK → KQSRSVFPEH...IGLPTPPTTT

Note: May be due to competing acceptor splice site.Curated
Show »
Length:1,623
Mass (Da):176,483
Checksum:i098F1010FBE909F1
GO
Isoform 5 (identifier: B9EJA2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-680: VGAWPAGTPGLNQPACSDSSLVIPATVAFCSSINPVSASSRSPGASDSLLVAASG → KIQKVKCTREEPSC

Show »
Length:1,607
Mass (Da):175,193
Checksum:iF1CDBDB0188294FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q1W8F6Q1W8_MOUSE
Cortactin-binding protein 2
Cttnbp2
1,139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1E3D3Z1E3_MOUSE
Cortactin-binding protein 2
Cttnbp2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z551D3Z551_MOUSE
Cortactin-binding protein 2
Cttnbp2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XSM7F6XSM7_MOUSE
Cortactin-binding protein 2
Cttnbp2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32532 differs from that shown. Erroneous CDS prediction and frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti521V → F in AK028980 (PubMed:16141072).Curated1
Sequence conflicti661V → F in AK028980 (PubMed:16141072).Curated1
Sequence conflicti1619S → SSS in AAI41408 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046473626 – 680VGAWP…VAASG → KIQKVKCTREEPSC in isoform 5. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_046474626 – 630VGAWP → AGHPP in isoform 2. 1 Publication5
Alternative sequenceiVSP_046475631 – 1648Missing in isoform 2. 1 PublicationAdd BLAST1018
Alternative sequenceiVSP_046476681 – 710WSPSL…QAAAQ → KGIEVFYPFVKNVPYSLTSL NFFYVVLKRF in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_046477711 – 1648Missing in isoform 3. 1 PublicationAdd BLAST938
Alternative sequenceiVSP_0464781568 – 1648EASPP…EKPNK → KQSRSVFPEHQKKQQQQQYK ATRNQQQLQRRELDLRQTRT SRKTKQIGLPTPPTTT in isoform 4. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK028980 mRNA No translation available.
AK032356 mRNA Translation: BAC27832.1
AK078315 mRNA Translation: BAC37216.1
AC027654 Genomic DNA No translation available.
AC158663 Genomic DNA No translation available.
CH466533 Genomic DNA Translation: EDL13863.1
BC068156 mRNA No translation available.
BQ769661 mRNA No translation available.
BC141407 mRNA Translation: AAI41408.1
CB526439 mRNA No translation available.
AK173254 mRNA Translation: BAD32532.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39432.1 [B9EJA2-1]

NCBI Reference Sequences

More...RefSeqi		NP_525024.1, NM_080285.1 [B9EJA2-1]
XP_006505167.1, XM_006505104.2 [B9EJA2-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000090601; ENSMUSP00000088089; ENSMUSG00000000416 [B9EJA2-1]
ENSMUST00000148602; ENSMUSP00000118432; ENSMUSG00000000416 [B9EJA2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		30785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:30785

UCSC genome browser

More...UCSCi		uc009bak.1, mouse [B9EJA2-1]
uc009ban.1, mouse [B9EJA2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028980 mRNA No translation available.
AK032356 mRNA Translation: BAC27832.1
AK078315 mRNA Translation: BAC37216.1
AC027654 Genomic DNA No translation available.
AC158663 Genomic DNA No translation available.
CH466533 Genomic DNA Translation: EDL13863.1
BC068156 mRNA No translation available.
BQ769661 mRNA No translation available.
BC141407 mRNA Translation: AAI41408.1
CB526439 mRNA No translation available.
AK173254 mRNA Translation: BAD32532.1 Sequence problems.
CCDSiCCDS39432.1 [B9EJA2-1]
RefSeqiNP_525024.1, NM_080285.1 [B9EJA2-1]
XP_006505167.1, XM_006505104.2 [B9EJA2-5]

3D structure databases

AlphaFoldDBiB9EJA2
SMRiB9EJA2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205963, 27 interactors
IntActiB9EJA2, 4 interactors
STRINGi10090.ENSMUSP00000088089

PTM databases

iPTMnetiB9EJA2
PhosphoSitePlusiB9EJA2

Proteomic databases

PaxDbiB9EJA2
PeptideAtlasiB9EJA2
PRIDEiB9EJA2
ProteomicsDBi279291 [B9EJA2-1]
279292 [B9EJA2-2]
279293 [B9EJA2-3]
279294 [B9EJA2-4]
279295 [B9EJA2-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3970, 93 antibodies from 19 providers

Genome annotation databases

EnsembliENSMUST00000090601; ENSMUSP00000088089; ENSMUSG00000000416 [B9EJA2-1]
ENSMUST00000148602; ENSMUSP00000118432; ENSMUSG00000000416 [B9EJA2-2]
GeneIDi30785
KEGGimmu:30785
UCSCiuc009bak.1, mouse [B9EJA2-1]
uc009ban.1, mouse [B9EJA2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83992
MGIiMGI:1353467, Cttnbp2
VEuPathDBiHostDB:ENSMUSG00000000416

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502QWG2, Eukaryota
GeneTreeiENSGT00940000158293
HOGENOMiCLU_028813_1_0_1
InParanoidiB9EJA2
OMAiMCPVEAL
OrthoDBi264951at2759
PhylomeDBiB9EJA2
TreeFamiTF325130

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		30785, 1 hit in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cttnbp2, mouse

Protein Ontology

More...PROi		PR:B9EJA2
RNActiB9EJA2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000000416, Expressed in Ammon's horn and 233 other tissues
ExpressionAtlasiB9EJA2, baseline and differential
GenevisibleiB9EJA2, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR019131, Cortactin-binding_p2_N
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF09727, CortBP2, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTTB2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9EJA2
Secondary accession number(s): G3X9L7
, Q69ZB2, Q8BVG1, Q8C044
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2013
Last modified: May 25, 2022
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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