Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - B9EJA2 (CTTB2_MOUSE)

Protein

Cortactin-binding protein 2

Gene

Cttnbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
Gene namesi
Name:Cttnbp2
Synonyms:Kiaa1758
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1353467 Cttnbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi540P → A: Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-543. 1 Publication1
Mutagenesisi543P → A: Almost complete loss of CTTN-binding and loss of regulation of spine density; when associated with A-540. 1 Publication1
Mutagenesisi599P → A: Reduced CTTN-binding; when associated with A-602. 1 Publication1
Mutagenesisi602P → A: Reduced CTTN-binding; when associated with A-599. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004221721 – 1648Cortactin-binding protein 2Add BLAST1648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei495Asymmetric dimethylarginineCombined sources1
Modified residuei1510PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiB9EJA2
PeptideAtlasiB9EJA2
PRIDEiB9EJA2

PTM databases

iPTMnetiB9EJA2
PhosphoSitePlusiB9EJA2

Expressioni

Tissue specificityi

Isoform 2 is predominantly expressed in brain (at protein level). In the brain, expressed at high levels in hypothalamus and striatum and at lower levels in cerebellum and cortex.2 Publications

Gene expression databases

BgeeiENSMUSG00000000416 Expressed in 210 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiB9EJA2 baseline and differential
GenevisibleiB9EJA2 MM

Interactioni

Subunit structurei

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons (By similarity). Activation of glutamate receptors weakens the interaction with STRN and STRN4 (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi205963, 4 interactors
IntActiB9EJA2, 3 interactors
STRINGi10090.ENSMUSP00000088089

Structurei

3D structure databases

SMRiB9EJA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati699 – 729ANK 1Add BLAST31
Repeati733 – 762ANK 2Add BLAST30
Repeati766 – 795ANK 3Add BLAST30
Repeati799 – 828ANK 4Add BLAST30
Repeati832 – 861ANK 5Add BLAST30
Repeati901 – 931ANK 6Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 274Sequence analysisAdd BLAST156

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IGN3 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150884
HOGENOMiHOG000112055
HOVERGENiHBG072413
InParanoidiB9EJA2
OMAiKMSIDKP
OrthoDBiEOG091G0CSA
TreeFamiTF325130

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF09727 CortBP2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B9EJA2-1) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDSASCEP DLSRTPGDTE GATAEAAKKE FDVDTLSKSE LRMLLSVMEG 
        60         70         80         90        100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGPGDKEK 
       110        120        130        140        150
PVCTNPLSIL EAVMAHCRKM QERMSAQLVA AESRQKKLEM EKLQLQALEQ 
       160        170        180        190        200
EHKKLAAHLE EERGKNKHVV LMLVKECKQL SGKVVEEAQK LEEVMAQLEE 
       210        220        230        240        250
EKKKTSELEE QLSAEKQRSS GMEAQLEKQL SEFDTEREQL RAKLSREEAH 
       260        270        280        290        300
TTDLKEEIDK MKKMMEQMKK GSDGKPGLSL PRKTKDKRLA SISVATEGPV 
       310        320        330        340        350
TRSVACQTDV VTESTDPVKK LPLTVPIKPS TGSPLVPTNT KGNVGPSALL 
       360        370        380        390        400
IRPGIDRQSS HSDLGPSPPT ALPSSANRIE ENGPSTGNAP DLSNSTPSTP 
       410        420        430        440        450
SSTAPAAAQT PGTAPQNHSQ APTVHSLHSP CANTHPGLNP RIQAARFRFQ 
       460        470        480        490        500
GNANDPDQNG NNTQSPPSRD VSPTSRDNLV AKQLARNTVT QALSRFTSPQ 
       510        520        530        540        550
AGASSRLGVS PGGDAGTCPP VGRTGLKTPG AARVDRGNPP PIPPKKPGLS 
       560        570        580        590        600
QTPSPPHPQL RASNAGAKVD NKIVASPPST LPQGTKVVNE ENVPKSSSPQ 
       610        620        630        640        650
LPPKPSIDLT VAPAGCPVSA LATSQVGAWP AGTPGLNQPA CSDSSLVIPA 
       660        670        680        690        700
TVAFCSSINP VSASSRSPGA SDSLLVAASG WSPSLTPLLM SGGPAPLAGR 
       710        720        730        740        750
PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV 
       760        770        780        790        800
RLLLNAEARV DAADKNGFTP LCVAAAQGHF ECIELLTAYN ANINHSAAGG 
       810        820        830        840        850
QTPLYLACKN GNKECIKLLL EAGTDRSIKT RDGWTPIHAA VDTGNVDSLK 
       860        870        880        890        900
LLMYHRVRAH GNSLSSEEPK SGLFSLNGGE SPTGPSKPVV PADLINHADK 
       910        920        930        940        950
EGWTAAHIAA SKGFKNCLEV LCRHGGLEPE RRDKCNRTVH DVATDDCKHL 
       960        970        980        990       1000
LENLNALKIP LRISVGEIQP SNDVSDDFEC EHTICTLNIR KQTSWEDFSK 
      1010       1020       1030       1040       1050
AVSQALTNHF QAISSDGWWS LEDGTFNNAT DSCIGLGTSS IRSIMLGSMP 
      1060       1070       1080       1090       1100
WSTGQSFSQS PWDFLKKKKV EQVLALLSGP QEGCLSSVTY ASMIPLQMLQ 
      1110       1120       1130       1140       1150
NYLRLVEQYH NVIFHGPEGS LQDYIANQLA LCMKYRQMAA GFPCEIVRAE 
      1160       1170       1180       1190       1200
VDSGFSKEQL VDVFIRNACL IPVKQFPVKK KIIVILENLE KSSLSELLGD 
      1210       1220       1230       1240       1250
FLAPLENRST ESPCTFQKGN GTSECYYFHE NCFLVGTIAK ACLQGSDLLV 
      1260       1270       1280       1290       1300
QQHFRWVQLR WDCEPIQGLL QRFLRRKVVS KFRGQLPAPC DPVCKIVDWA 
      1310       1320       1330       1340       1350
LSVWRQLNSC LARLGTPEAL LGPKYFLSCP VVPGHAQATV KWMSKLWNAV 
      1360       1370       1380       1390       1400
IAPRVQEAIL SRASMNKQPG TGQTASKKYP SQGQQAVVRA ALSILLNKAV 
      1410       1420       1430       1440       1450
LHGCPLPRAE LDQQIADFKG GSFPLSIVSS YSKKKVESGA WRKVNTSPRK 
      1460       1470       1480       1490       1500
KPGHFSSPTW NKPDPKREGM RNKTIPHLNT NRNSSLSKQQ SLENDLSVTL 
      1510       1520       1530       1540       1550
TLDHRLSLGS DDEADLVKEL QSMCSSKSES DISKIADSRD DLRKFDSSRT 
      1560       1570       1580       1590       1600
NPGTSAPLNL RTPVPQKEAS PPSSRQTAEC SNSKSKTEMG VSSVKSFLPV 
      1610       1620       1630       1640 
PRSKVAQCSQ NTKRNSSSSN TRQLEINNNS KEENWTLDKH EQVEKPNK
Length:1,648
Mass (Da):178,774
Last modified:May 1, 2013 - v2
Checksum:i7C7016DB9E61D7E0
GO
Isoform 2 (identifier: B9EJA2-2) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     626-630: VGAWP → AGHPP
     631-1648: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:630
Mass (Da):67,549
Checksum:iDAB904B4C2086805
GO
Isoform 3 (identifier: B9EJA2-3) [UniParc]FASTAAdd to basket
Also known as: CTTNBP2-intron

The sequence of this isoform differs from the canonical sequence as follows:
     681-710: WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQ → KGIEVFYPFVKNVPYSLTSLNFFYVVLKRF
     711-1648: Missing.

Note: Due to intron retention.
Show »
Length:710
Mass (Da):75,900
Checksum:i9418424395611C6B
GO
Isoform 4 (identifier: B9EJA2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1568-1648: EASPPSSRQT...KHEQVEKPNK → KQSRSVFPEH...IGLPTPPTTT

Note: May be due to competing acceptor splice site. No experimental confirmation available.
Show »
Length:1,623
Mass (Da):176,483
Checksum:i098F1010FBE909F1
GO
Isoform 5 (identifier: B9EJA2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-680: VGAWPAGTPGLNQPACSDSSLVIPATVAFCSSINPVSASSRSPGASDSLLVAASG → KIQKVKCTREEPSC

Note: No experimental confirmation available.
Show »
Length:1,607
Mass (Da):175,193
Checksum:iF1CDBDB0188294FB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q1W8F6Q1W8_MOUSE
Cortactin-binding protein 2
Cttnbp2
1,139Annotation score:
D3Z1E3D3Z1E3_MOUSE
Cortactin-binding protein 2
Cttnbp2
160Annotation score:
D3Z551D3Z551_MOUSE
Cortactin-binding protein 2
Cttnbp2
94Annotation score:
F6XSM7F6XSM7_MOUSE
Cortactin-binding protein 2
Cttnbp2
193Annotation score:

Sequence cautioni

The sequence BAD32532 differs from that shown. Erroneous CDS prediction and frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti521V → F in AK028980 (PubMed:16141072).Curated1
Sequence conflicti661V → F in AK028980 (PubMed:16141072).Curated1
Sequence conflicti1619S → SSS in AAI41408 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046473626 – 680VGAWP…VAASG → KIQKVKCTREEPSC in isoform 5. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_046474626 – 630VGAWP → AGHPP in isoform 2. 1 Publication5
Alternative sequenceiVSP_046475631 – 1648Missing in isoform 2. 1 PublicationAdd BLAST1018
Alternative sequenceiVSP_046476681 – 710WSPSL…QAAAQ → KGIEVFYPFVKNVPYSLTSL NFFYVVLKRF in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_046477711 – 1648Missing in isoform 3. 1 PublicationAdd BLAST938
Alternative sequenceiVSP_0464781568 – 1648EASPP…EKPNK → KQSRSVFPEHQKKQQQQQYK ATRNQQQLQRRELDLRQTRT SRKTKQIGLPTPPTTT in isoform 4. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028980 mRNA No translation available.
AK032356 mRNA Translation: BAC27832.1
AK078315 mRNA Translation: BAC37216.1
AC027654 Genomic DNA No translation available.
AC158663 Genomic DNA No translation available.
CH466533 Genomic DNA Translation: EDL13863.1
BC068156 mRNA No translation available.
BQ769661 mRNA No translation available.
BC141407 mRNA Translation: AAI41408.1
CB526439 mRNA No translation available.
AK173254 mRNA Translation: BAD32532.1 Sequence problems.
CCDSiCCDS39432.1 [B9EJA2-1]
RefSeqiNP_525024.1, NM_080285.1 [B9EJA2-1]
XP_006505167.1, XM_006505104.2 [B9EJA2-5]
UniGeneiMm.224189

Genome annotation databases

EnsembliENSMUST00000090601; ENSMUSP00000088089; ENSMUSG00000000416 [B9EJA2-1]
ENSMUST00000148602; ENSMUSP00000118432; ENSMUSG00000000416 [B9EJA2-2]
GeneIDi30785
KEGGimmu:30785
UCSCiuc009bak.1 mouse [B9EJA2-1]
uc009ban.1 mouse [B9EJA2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028980 mRNA No translation available.
AK032356 mRNA Translation: BAC27832.1
AK078315 mRNA Translation: BAC37216.1
AC027654 Genomic DNA No translation available.
AC158663 Genomic DNA No translation available.
CH466533 Genomic DNA Translation: EDL13863.1
BC068156 mRNA No translation available.
BQ769661 mRNA No translation available.
BC141407 mRNA Translation: AAI41408.1
CB526439 mRNA No translation available.
AK173254 mRNA Translation: BAD32532.1 Sequence problems.
CCDSiCCDS39432.1 [B9EJA2-1]
RefSeqiNP_525024.1, NM_080285.1 [B9EJA2-1]
XP_006505167.1, XM_006505104.2 [B9EJA2-5]
UniGeneiMm.224189

3D structure databases

SMRiB9EJA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205963, 4 interactors
IntActiB9EJA2, 3 interactors
STRINGi10090.ENSMUSP00000088089

PTM databases

iPTMnetiB9EJA2
PhosphoSitePlusiB9EJA2

Proteomic databases

PaxDbiB9EJA2
PeptideAtlasiB9EJA2
PRIDEiB9EJA2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090601; ENSMUSP00000088089; ENSMUSG00000000416 [B9EJA2-1]
ENSMUST00000148602; ENSMUSP00000118432; ENSMUSG00000000416 [B9EJA2-2]
GeneIDi30785
KEGGimmu:30785
UCSCiuc009bak.1 mouse [B9EJA2-1]
uc009ban.1 mouse [B9EJA2-3]

Organism-specific databases

CTDi83992
MGIiMGI:1353467 Cttnbp2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGN3 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150884
HOGENOMiHOG000112055
HOVERGENiHBG072413
InParanoidiB9EJA2
OMAiKMSIDKP
OrthoDBiEOG091G0CSA
TreeFamiTF325130

Miscellaneous databases

ChiTaRSiCttnbp2 mouse
PROiPR:B9EJA2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000416 Expressed in 210 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiB9EJA2 baseline and differential
GenevisibleiB9EJA2 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF09727 CortBP2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCTTB2_MOUSE
AccessioniPrimary (citable) accession number: B9EJA2
Secondary accession number(s): G3X9L7
, Q69ZB2, Q8BVG1, Q8C044
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2013
Last modified: November 7, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again