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Protein

CAP-Gly domain-containing linker protein 3

Gene

Clip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity).By similarity

Miscellaneous

The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5357905 Regulation of TNFR1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 3
Alternative name(s):
Cytoplasmic linker protein 170-related 59 kDa protein
Short name:
CLIP-170-related 59 kDa protein
Short name:
CLIPR-59
Gene namesi
Name:Clip3
Synonyms:Clipr59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923936 Clip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004156701 – 547CAP-Gly domain-containing linker protein 3Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei374PhosphothreonineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Lipidationi534S-palmitoyl cysteineBy similarity1
Lipidationi535S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation by ZDHHC17 regulates association with the plasma membrane.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiB9EHT4
PaxDbiB9EHT4
PeptideAtlasiB9EHT4
PRIDEiB9EHT4

PTM databases

iPTMnetiB9EHT4
PhosphoSitePlusiB9EHT4

Expressioni

Gene expression databases

BgeeiENSMUSG00000013921
ExpressionAtlasiB9EHT4 baseline and differential
GenevisibleiB9EHT4 MM

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1 and AKT2; when AKT1 and AKT2 are phosphorylated and activated, affinity is higher for AKT2 (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218260, 2 interactors
STRINGi10090.ENSMUSP00000014065

Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi406 – 409Combined sources4
Beta strandi420 – 424Combined sources5
Turni425 – 427Combined sources3
Beta strandi428 – 437Combined sources10
Beta strandi439 – 449Combined sources11
Beta strandi451 – 453Combined sources3
Beta strandi456 – 461Combined sources6
Turni471 – 473Combined sources3
Beta strandi474 – 477Combined sources4
Helixi479 – 481Combined sources3
Beta strandi482 – 484Combined sources3

3D structure databases

ProteinModelPortaliB9EHT4
SMRiB9EHT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati117 – 158ANK 1Add BLAST42
Repeati160 – 191ANK 2Add BLAST32
Repeati197 – 229ANK 3Add BLAST33
Domaini314 – 356CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini436 – 478CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni488 – 547GoLDAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 25Poly-Glu10

Domaini

Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).By similarity

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000007206
HOVERGENiHBG057079
InParanoidiB9EHT4
KOiK10423
OMAiICPPKLG
OrthoDBiEOG091G04NK
PhylomeDBiB9EHT4
TreeFamiTF326096

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01302 CAP_GLY, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

Sequencei

Sequence statusi: Complete.

B9EHT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTDPAPMA PPPRGEEEEE EEEDEPVPEA PSPTQERRQK PVVHPSAPAP
60 70 80 90 100
LPKDYAFTFF DPNDPACQEI LFDPKTTIPE LFAIVRQWVP QVQHKIDVIG
110 120 130 140 150
NEILRRGCHV NDRDGLTDMT LLHYACKAGA HGVGDPAAAV RLSQQLLALG
160 170 180 190 200
ADVTLRSRWT NMNALHYAAY FDVPDLVRVL LKGARPRVVN STCSDFNHGS
210 220 230 240 250
ALHIAASNLC LGAAKCLLEH GANPALRNRK GQVPAEVVPD PMDMSLDKAE
260 270 280 290 300
AALVAKELRT LLEEAVPLSC TLPKVTLPNY DNVPGNLMLS ALGLRLGDRV
310 320 330 340 350
LLDGQKTGTL RFCGTTEFAS GQWVGVELDE PEGKNDGSVG GVRYFICPPK
360 370 380 390 400
QGLFASVSKV SKAVDAPPSS VTSTPRTPRM DFSRVTGKGR REHKGKKKSP
410 420 430 440 450
SSPSLGSLQQ REGAKAEVGD QVLVAGQKQG IVRFYGKTDF APGYWYGIEL
460 470 480 490 500
DQPTGKHDGS VFGVRYFTCA PRHGVFAPAS RIQRIGGSTD PPGDSVGAKK
510 520 530 540
VHQVTMTQPK RTFTTVRTPK DIASENSISR LLFCCWFPWM LRAEMQS
Length:547
Mass (Da):59,587
Last modified:March 24, 2009 - v1
Checksum:i851B8B94DA20A1AD
GO

Sequence cautioni

The sequence BAB23857 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149067 Genomic DNA No translation available.
CH466593 Genomic DNA Translation: EDL24034.1
BC056173 mRNA Translation: AAH56173.1
BC138413 mRNA Translation: AAI38414.1
AK005167 mRNA Translation: BAB23857.1 Different initiation.
CCDSiCCDS39880.1
RefSeqiNP_001074583.1, NM_001081114.1
XP_006540473.1, XM_006540410.3
XP_006540474.1, XM_006540411.3
UniGeneiMm.159258

Genome annotation databases

EnsembliENSMUST00000014065; ENSMUSP00000014065; ENSMUSG00000013921
GeneIDi76686
KEGGimmu:76686
UCSCiuc009gea.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCLIP3_MOUSE
AccessioniPrimary (citable) accession number: B9EHT4
Secondary accession number(s): Q7TNI1, Q9DB67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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