We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - B9EHK7 (B9EHK7_MOUSE)
Protein
Submitted name:
Homeo box A1
Gene
Hoxa1
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 230 – 289 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeo box A1ImportedSubmitted name: Homeobox protein Hox-A1Imported |
Gene namesi | Name:Hoxa1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96170, Hoxa1 |
VEuPathDBi | HostDB:ENSMUSG00000029844 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000029844, Expressed in primitive streak and 162 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 228 – 288 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 62 – 84 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 284 – 336 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 62 – 77 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 314 – 336 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157315 |
HOGENOMi | CLU_058839_1_1_1 |
OMAi | QCGPLMY |
OrthoDBi | 1216870at2759 |
TreeFami | TF317730 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
B9EHK7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNARMNSFL EYPILGSGDS GTCSARAYPS DHGITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLVGRGVQ ISSPHHHHHH HHHHHPQTAT YQTSGNLGIS YSHSSCGPSY
110 120 130 140 150
GAQNFSAPYG PYGLNQEADV SGGYPPCAPA VYSGNLSTPM VQHHHHHQGY
160 170 180 190 200
AGGTVGSPQY IHHSYGQEQQ TLALATYNNS LSPLHASHQE ACRSPASETS
210 220 230 240 250
SPAQTFDWMK VKRNPPKTGK VGEYGYVGQP NAVRTNFTTK QLTELEKEFH
260 270 280 290 300
FNKYLTRARR VEIAASLQLN ETQVKIWFQN RRMKQKKREK EGLLPISPAT
310 320 330
PPGSDEKTEE SSEKSSPSPS APSPASSTSD TLTTSH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09022 | HXA1_MOUSE | Homeobox protein Hox-A1 | Hoxa1 Era-1, Hox-1.6, Hoxa-1 | 331 | Annotation score: | ||
D3Z4E1 | D3Z4E1_MOUSE | Homeobox protein Hox-A1 | Hoxa1 | 138 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138097 mRNA Translation: AAI38098.1 |
RefSeqi | NP_034579.3, NM_010449.4 XP_006505670.1, XM_006505607.2 |
Genome annotation databases
Ensembli | ENSMUST00000000964; ENSMUSP00000000964; ENSMUSG00000029844 |
GeneIDi | 15394 |
UCSCi | uc009bxy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138097 mRNA Translation: AAI38098.1 |
RefSeqi | NP_034579.3, NM_010449.4 XP_006505670.1, XM_006505607.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B9EHK7, 3 interactors |
Proteomic databases
ProteomicsDBi | 330321 |
Protocols and materials databases
Antibodypediai | 1429, 352 antibodies from 31 providers |
DNASUi | 15394 |
Genome annotation databases
Ensembli | ENSMUST00000000964; ENSMUSP00000000964; ENSMUSG00000029844 |
GeneIDi | 15394 |
UCSCi | uc009bxy.1, mouse |
Organism-specific databases
CTDi | 3198 |
MGIi | MGI:96170, Hoxa1 |
VEuPathDBi | HostDB:ENSMUSG00000029844 |
Phylogenomic databases
GeneTreei | ENSGT00940000157315 |
HOGENOMi | CLU_058839_1_1_1 |
OMAi | QCGPLMY |
OrthoDBi | 1216870at2759 |
TreeFami | TF317730 |
Miscellaneous databases
BioGRID-ORCSi | 15394, 0 hits in 65 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029844, Expressed in primitive streak and 162 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B9EHK7_MOUSE | |
Accessioni | B9EHK7Primary (citable) accession number: B9EHK7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 24, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | January 19, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |