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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei577ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MCCL_1435
OrganismiMacrococcus caseolyticus (strain JCSC5402)
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeMacrococcus
Proteomesi
  • UP000001383 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001992131 – 802Leucine--tRNA ligaseAdd BLAST802

Interactioni

Protein-protein interaction databases

STRINGi458233.MCCL_1435

Structurei

3D structure databases

ProteinModelPortaliB9E7H4
SMRiB9E7H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 50"HIGH" regionAdd BLAST12
Motifi574 – 578"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B9E7H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFNHQTIEK KWQKYWLDNH TFKTTEDKDK NFYALDMFPY PSGAGLHVGH
60 70 80 90 100
PEGYTATDII SRFKRMQGYN VLHPMGWDAF GLPAEQYAID TGNDPAEFTE
110 120 130 140 150
KNIATFKRQI QELGFSYDWE REINTTDPEY YKWTQWIFIQ LYKKGLAYVD
160 170 180 190 200
EVAVNWCPAL GTVLSNEEVI DGVSERGGHP VIRKPMRQWV LKITEYADRL
210 220 230 240 250
LEDLEELDWP ESLKDMQRNW IGRSEGAEVA FEVENLDHSF KVFTTRPDTI
260 270 280 290 300
YGATYAVLSP EHELVAAITS EEQAEAVKAY QEQAARKSDL ERTDLAKDKT
310 320 330 340 350
GVFTGSYAIN PFNGERMPIW ISDYVLASYG TGAIMAVPAH DERDFEFAKQ
360 370 380 390 400
FGLDIKPVIE GGDNTSAYTG DGAHINSGEL DGLNKEEGIR RAIELLEAKG
410 420 430 440 450
IGEKKVSYKL RDWLFSRQRY WGEPIPVITW EDGSMTTVPE EELPLMLPKT
460 470 480 490 500
EHIKPSGTGE SPLANIDEFV NVTDPVTGMK GRRETNTMPQ WAGSCWYYLR
510 520 530 540 550
YIDPKNSDMI ADPELLKKWL PVDLYIGGAE HAVLHLLYAR FWHKVLYDLG
560 570 580 590 600
VVHTKEPFQK LFNQGMILGE GNEKMSKSKG NVVNPDDVVA SHGADTLRLY
610 620 630 640 650
EMFMGPLDAS IAWSTNGLDG ARRFLDRVYR LLVNEDGTLS EKITEQPVGS
660 670 680 690 700
MEKVYHQTVK KVTDDYETLG FNTAISQMMV FINEGYKSEQ LNIDHIRGFV
710 720 730 740 750
KLLNPIAPHI TEELWEKLGG TESITYEAWP VYDESKLVDS EVEIVIQVNG
760 770 780 790 800
KLKQKATIAK DMDKSEMETF ALSLEAVQTA IEGKTVRKVI AVPNKLVNIV

AN
Length:802
Mass (Da):91,101
Last modified:March 24, 2009 - v1
Checksum:i456BBFFEAA2D2A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA Translation: BAH18142.1
RefSeqiWP_012657340.1, NC_011999.1

Genome annotation databases

EnsemblBacteriaiBAH18142; BAH18142; MCCL_1435
KEGGimcl:MCCL_1435

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA Translation: BAH18142.1
RefSeqiWP_012657340.1, NC_011999.1

3D structure databases

ProteinModelPortaliB9E7H4
SMRiB9E7H4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi458233.MCCL_1435

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH18142; BAH18142; MCCL_1435
KEGGimcl:MCCL_1435

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_MACCJ
AccessioniPrimary (citable) accession number: B9E7H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 10, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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