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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene

hemL1

Organism
Macrococcus caseolyticus (strain JCSC5402)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase 2 (hemL2), Glutamate-1-semialdehyde 2,1-aminomutase 1 (hemL1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSA 1UniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1UniRule annotation
Short name:
GSA-AT 1UniRule annotation
Gene namesi
Name:hemL1UniRule annotation
Ordered Locus Names:MCCL_1301
OrganismiMacrococcus caseolyticus (strain JCSC5402)
Taxonomic identifieri458233 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeMacrococcus
Proteomesi
  • UP000001383 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823401 – 427Glutamate-1-semialdehyde 2,1-aminomutase 1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB9E740

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi458233.MCCL_1301

Structurei

3D structure databases

ProteinModelPortaliB9E740
SMRiB9E740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B9E740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSKSKQAF KEAVNLMPGG VNSPVRAFKS VDMDPIFMER GKGSKIYDID
60 70 80 90 100
GNEYIDYVLS WGPLILGHAN DTVTGALNKA VLNGTSFGAP TELENKMAEL
110 120 130 140 150
VIERVPSIEM VRMVSSGTEA TLAALRLARG FTGKNKILKF IGCYHGHSDS
160 170 180 190 200
LLIKAGSGVA TLGLPDSPGV PKGTAENTIT VHYNDLDAVK LAFEQFGDDI
210 220 230 240 250
AGVIVEPVAG NMGVVPPVEG FLEGLREITT EHGALLIFDE VMTGFRVGYN
260 270 280 290 300
CAQGYFGVIP DLTCLGKVIG GGLPVGAFGG RKDIMEHIAP SGPVYQAGTL
310 320 330 340 350
SGNPLAMTGG YYTLSQLTPE SYEYFNHLGD MLEAGLTDVF AKHNVPITIN
360 370 380 390 400
RAGSMIGFFL NEEKVTNFEI ASKSDLKLFA AMYKEMANNG VFLPPSQFEG
410 420
MFLSTEHTEE DIQKTINAFD NSLTVIL
Length:427
Mass (Da):45,893
Last modified:March 24, 2009 - v1
Checksum:i6393B1BB9E748849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009484 Genomic DNA Translation: BAH18008.1
RefSeqiWP_012657206.1, NC_011999.1

Genome annotation databases

EnsemblBacteriaiBAH18008; BAH18008; MCCL_1301
KEGGimcl:MCCL_1301

Similar proteinsi

Entry informationi

Entry nameiGSA1_MACCJ
AccessioniPrimary (citable) accession number: B9E740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 24, 2009
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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