UniProtKB - B9DI82 (B9DI82_HUMAN)
Protein
Phosphoinositide phospholipase C
Gene
PLCH2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+UniRule annotationARBA annotationEC:3.1.4.11UniRule annotationARBA annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 41 – 52 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
GO - Biological processi
- intracellular signal transduction Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseUniRule annotation, TransducerARBA annotation |
Biological process | Lipid degradationUniRule annotationARBA annotation, Lipid metabolism |
Ligand | CalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoinositide phospholipase CUniRule annotationARBA annotation (EC:3.1.4.11UniRule annotationARBA annotation) |
Gene namesi | Name:PLCH2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149527.17 |
HGNCi | HGNC:29037, PLCH2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149527, Expressed in right hemisphere of cerebellum and 151 other tissues |
ExpressionAtlasi | B9DI82, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 63 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 64 – 100 | EF-handInterPro annotationAdd BLAST | 37 | |
Domaini | 485 – 573 | PI-PLC Y-boxInterPro annotationAdd BLAST | 89 | |
Domaini | 568 – 675 | C2InterPro annotationAdd BLAST | 108 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 336 – 360 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 394 – 479 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 726 – 1053 | DisorderedSequence analysisAdd BLAST | 328 | |
Regioni | 1138 – 1229 | DisorderedSequence analysisAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 355 | AcidicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 394 – 408 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 410 – 427 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 833 – 848 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 962 – 981 | PolarSequence analysisAdd BLAST | 20 |
Phylogenomic databases
GeneTreei | ENSGT00940000158374 |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 2 hits PTHR10336:SF166, PTHR10336:SF166, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50008, PIPLC_Y_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
B9DI82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XARTWVTGLR YLMAGISDED SLARRQRTRD QWLKQTFDEA DKNGDGSLSI
60 70 80 90 100
GEVLQLLHKL NVNLPRQRVK QMFREADTDD HQGTLGFEEF CAFYKMMSTR
110 120 130 140 150
RDLYLLMLTY SNHKDHLDAA SLQRFLQVEQ KMAGVTLESC QDIIEQFEPC
160 170 180 190 200
PENKSKGLLG IDGFTNYTRS PAGDIFNPEH HHVHQDMTQP LSHYFITSSH
210 220 230 240 250
NTYLVGDQLM SQSRVDMYAW VLQAGCRCVE VDCWDGPDGE PIVHHGYTLT
260 270 280 290 300
SKILFKDVIE TINKYAFIKN EYPVILSIEN HCSVIQQKKM AQYLTDILGD
310 320 330 340 350
KLDLSSVSSE DATTLPSPQM LKGKILVKGK KLPANISEDA EEGEVSDEDS
360 370 380 390 400
ADEIDDDCKL LNGDASTNRK RVENTAKRKL DSLIKESKIR DCEDPNNFSV
410 420 430 440 450
STLSPSGKLG RKSKAEEDVE SGEDAGASRR NGRLVVGSFS RRKKKGSKLK
460 470 480 490 500
KAASVEEGDE GQDSPGGQSR GATRQKKTMK LSRALSDLVK YTKSVATHDI
510 520 530 540 550
EMEAASSWQV SSFSETKAHQ ILQQKPAQYL RFNQQQLSRI YPSSYRVDSS
560 570 580 590 600
NYNPQPFWNA GCQMGVFNPN SEDPLPGQLK KQLVLRIISG QQLPKPRDSM
610 620 630 640 650
LGDRGEIIDP FVEVEIIGLP VDCSREQTRV VDDNGFNPTW EETLVFMVHM
660 670 680 690 700
PEIALVRFLV WDHDPIGRDF IGQRTLAFSS MMPGYRHVYL EGMEEASIFV
710 720 730 740 750
HVAVSDISGK VKQALGLKGL FLRGPKPGSL DSHAAGRPPA RPSVSQRILR
760 770 780 790 800
RTASAPTKSQ KPGRRGFPEL VLGTRDTGSK GVADDVVPPG PGPAPEAPAQ
810 820 830 840 850
EGPGSGSPRD TRPLSTQRPL PPLCSLETIA EEPAPGPGPP PPAAVPTSSS
860 870 880 890 900
QGRPPYPTGP GANVASPLED TEEPRDSRPR PCNGEGAGGA YERAPGSQTD
910 920 930 940 950
GRSQPRTLGH LPVIRRVKSE GQVPTEPLGG WRPLAAPFPA PAVYSDATGS
960 970 980 990 1000
DPLWQRLEPC GHRDSVSSSS SMSSSDTVID LSLPSLGLGR SRENLAGAHM
1010 1020 1030 1040 1050
GRLPPRPHSA SAARPDLPPV TKSKSNPNLR ATGQRPPIPD ELQPRSLAPR
1060 1070 1080 1090 1100
MAGLPFRPPW GCLSLVGVQD CPVAAKSKSL GDLTADDFAP SFEGGSRRLS
1110 1120 1130 1140 1150
HSLGLPGGTR RVSGPGVRRD TLTEQLRWLT VFQQAGDITS PTSLGPAGEG
1160 1170 1180 1190 1200
VAGGPGFVRR SSSRSHSRVR AIASRARQAQ ERQQRLQGLG RQGPPEEERG
1210 1220 1230
TPEGACSVGH EGSVDAPAPS KGALGPASAA AENLVLLRL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75038 | PLCH2_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCH2 KIAA0450, PLCL4 | 1,416 | Annotation score: | ||
V9GY64 | V9GY64_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCH2 | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139246 Genomic DNA No translation available. AL513477 Genomic DNA No translation available. AL513531 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000278878; ENSP00000278878; ENSG00000149527 |
UCSCi | uc057bmr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139246 Genomic DNA No translation available. AL513477 Genomic DNA No translation available. AL513531 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B9DI82 |
PRIDEi | B9DI82 |
ProteomicsDBi | 7521 |
Protocols and materials databases
Antibodypediai | 1163, 21 antibodies |
Genome annotation databases
Ensembli | ENST00000278878; ENSP00000278878; ENSG00000149527 |
UCSCi | uc057bmr.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149527.17 |
HGNCi | HGNC:29037, PLCH2 |
OpenTargetsi | ENSG00000149527 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158374 |
Miscellaneous databases
ChiTaRSi | PLCH2, human |
Gene expression databases
Bgeei | ENSG00000149527, Expressed in right hemisphere of cerebellum and 151 other tissues |
ExpressionAtlasi | B9DI82, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 2 hits PTHR10336:SF166, PTHR10336:SF166, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B9DI82_HUMAN | |
Accessioni | B9DI82Primary (citable) accession number: B9DI82 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 24, 2009 |
Last sequence update: | July 24, 2013 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |