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Entry version 70 (18 Sep 2019)
Sequence version 1 (24 Mar 2009)
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Protein

Vesicle-associated protein 2-2

Gene

PVA22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicle trafficking.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-associated protein 2-2
Alternative name(s):
Plant VAP homolog 22
Short name:
AtPVA22
VAMP-associated protein 2-2
Vesicle-associated protein 27-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PVA22
Synonyms:VAP27-2
Ordered Locus Names:At1g08820
ORF Names:F22O13.31
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G08820

The Arabidopsis Information Resource

More...
TAIRi
locus:2025585 AT1G08820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 363CytoplasmicSequence analysisAdd BLAST363
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei364 – 384Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004021741 – 386Vesicle-associated protein 2-2Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei279PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B9DHD7

PRoteomics IDEntifications database

More...
PRIDEi
B9DHD7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B9DHD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B9DHD7 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cowpea mosaic virus (CPMV) NTP-binding protein (NTB).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
22645, 7 interactors

Protein interaction database and analysis system

More...
IntActi
B9DHD7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G08820.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B9DHD7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 125MSPPROSITE-ProRule annotationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili300 – 353Sequence analysisAdd BLAST54

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0439 Eukaryota
COG5066 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000188310

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B9DHD7

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDRYTAN

Database of Orthologous Groups

More...
OrthoDBi
1332028at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B9DHD7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP

The PANTHER Classification System

More...
PANTHERi
PTHR10809 PTHR10809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00635 Motile_Sperm, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49354 SSF49354, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50202 MSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B9DHD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMPLLDIQP RTLQFAVDLK KQTSCVVQLT NTTHHYVAFK VKTTSPKKYC
60 70 80 90 100
VRPNVGVVAP KSTCEFTVIM QAFKEPPPDM VCKDKFLIQS TAVSAETTDE
110 120 130 140 150
DITASMFSKA EGKHIEENKL RVTLVPPSDS PELSPINTPK QGAVFEDSIL
160 170 180 190 200
KDRLYSQSET LAPPQYEGEI VKEPRMVGHD ELKAADNAKE LKTPKMATVD
210 220 230 240 250
FVEDRYTAND LKATKDSYDS SRMAKETGFD PIRSHKDADD GRAIKATTNL
260 270 280 290 300
DAPMKKAMDL PRDQGFTNGI AVDSEPKISK ERDVVQLQKT DGQNVRGLDE
310 320 330 340 350
LKLVKDIEEM KLKVDALESK LKQADSTISK LMEERSISSQ HRQSLQHELA
360 370 380
ELRTKKIVKE VHNGFPLLYV CVVAFIAYVI GHFLRT
Length:386
Mass (Da):43,270
Last modified:March 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC0307DD110E2739
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF99771 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC003981 Genomic DNA Translation: AAF99771.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28352.1
CP002684 Genomic DNA Translation: AEE28353.1
CP002684 Genomic DNA Translation: ANM59286.1
CP002684 Genomic DNA Translation: ANM59287.1
CP002684 Genomic DNA Translation: ANM59288.1
AK317489 mRNA Translation: BAH20154.1
AK317626 mRNA Translation: BAH20288.1
AY074512 mRNA Translation: AAL67126.1
AY364004 mRNA Translation: AAQ63967.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B86220
T00738

NCBI Reference Sequences

More...
RefSeqi
NP_001031004.1, NM_001035927.2
NP_001321655.1, NM_001331792.1
NP_001321656.1, NM_001331793.1
NP_001321657.1, NM_001331791.1
NP_172359.2, NM_100756.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G08820.1; AT1G08820.1; AT1G08820
AT1G08820.2; AT1G08820.2; AT1G08820
AT1G08820.3; AT1G08820.3; AT1G08820
AT1G08820.4; AT1G08820.4; AT1G08820
AT1G08820.5; AT1G08820.5; AT1G08820

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837404

Gramene; a comparative resource for plants

More...
Gramenei
AT1G08820.1; AT1G08820.1; AT1G08820
AT1G08820.2; AT1G08820.2; AT1G08820
AT1G08820.3; AT1G08820.3; AT1G08820
AT1G08820.4; AT1G08820.4; AT1G08820
AT1G08820.5; AT1G08820.5; AT1G08820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G08820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003981 Genomic DNA Translation: AAF99771.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28352.1
CP002684 Genomic DNA Translation: AEE28353.1
CP002684 Genomic DNA Translation: ANM59286.1
CP002684 Genomic DNA Translation: ANM59287.1
CP002684 Genomic DNA Translation: ANM59288.1
AK317489 mRNA Translation: BAH20154.1
AK317626 mRNA Translation: BAH20288.1
AY074512 mRNA Translation: AAL67126.1
AY364004 mRNA Translation: AAQ63967.1
PIRiB86220
T00738
RefSeqiNP_001031004.1, NM_001035927.2
NP_001321655.1, NM_001331792.1
NP_001321656.1, NM_001331793.1
NP_001321657.1, NM_001331791.1
NP_172359.2, NM_100756.2

3D structure databases

SMRiB9DHD7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi22645, 7 interactors
IntActiB9DHD7, 4 interactors
STRINGi3702.AT1G08820.1

PTM databases

iPTMnetiB9DHD7

Proteomic databases

PaxDbiB9DHD7
PRIDEiB9DHD7

Genome annotation databases

EnsemblPlantsiAT1G08820.1; AT1G08820.1; AT1G08820
AT1G08820.2; AT1G08820.2; AT1G08820
AT1G08820.3; AT1G08820.3; AT1G08820
AT1G08820.4; AT1G08820.4; AT1G08820
AT1G08820.5; AT1G08820.5; AT1G08820
GeneIDi837404
GrameneiAT1G08820.1; AT1G08820.1; AT1G08820
AT1G08820.2; AT1G08820.2; AT1G08820
AT1G08820.3; AT1G08820.3; AT1G08820
AT1G08820.4; AT1G08820.4; AT1G08820
AT1G08820.5; AT1G08820.5; AT1G08820
KEGGiath:AT1G08820

Organism-specific databases

AraportiAT1G08820
TAIRilocus:2025585 AT1G08820

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
HOGENOMiHOG000188310
InParanoidiB9DHD7
OMAiEDRYTAN
OrthoDBi1332028at2759
PhylomeDBiB9DHD7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B9DHD7

Gene expression databases

ExpressionAtlasiB9DHD7 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
PANTHERiPTHR10809 PTHR10809, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVAP22_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B9DHD7
Secondary accession number(s): Q6UQE9, Q8VXW8, Q9FRQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: March 24, 2009
Last modified: September 18, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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