UniProtKB - B9DGD6 (ACS_ARATH)
Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal
ACS
Functioni
Catalyzes the production of acetyl-CoA, an activated form of acetate that can be used for lipid synthesis or for energy generation. May play a limited role in the biosynthesis of lipids.
2 PublicationsCatalytic activityi
- EC:6.2.1.11 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 613 | By similarity | 1 |
GO - Molecular functioni
- acetate-CoA ligase activity Source: TAIR
- AMP binding Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- acetate metabolic process Source: TAIR
- acetyl-CoA biosynthetic process from acetate Source: InterPro
- fatty acid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT5G36880-MONOMER |
BRENDAi | 6.2.1.1, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal (EC:6.2.1.1)Alternative name(s): Acetate--CoA ligase Acetyl-CoA synthetase |
Gene namesi | Name:ACS Ordered Locus Names:At5g36880 ORF Names:F5H8.15 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G36880 |
TAIRi | locus:2149104, AT5G36880 |
Subcellular locationi
Peroxisome
Chloroplast
Chloroplast
- chloroplast Source: TAIR
- chloroplast stroma Source: TAIR
Cytosol
- cytosol Source: TAIR
Peroxisome
- glyoxysome Source: UniProtKB-SubCell
Other locations
- plastid Source: TAIR
Keywords - Cellular componenti
Chloroplast, Glyoxysome, Peroxisome, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 84 | ChloroplastSequence analysisAdd BLAST | 84 | |
ChainiPRO_0000415733 | 85 – 743 | Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomalAdd BLAST | 659 |
Proteomic databases
PaxDbi | B9DGD6 |
PRIDEi | B9DGD6 |
ProteomicsDBi | 244386 [B9DGD6-1] |
PTM databases
iPTMneti | B9DGD6 |
MetOSitei | B9DGD6 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
ExpressionAtlasi | B9DGD6, baseline and differential |
Genevisiblei | B9DGD6, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 18906, 4 interactors |
STRINGi | 3702.AT5G36880.2 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1175, Eukaryota |
InParanoidi | B9DGD6 |
OMAi | DHWWHDL |
OrthoDBi | 288915at2759 |
PhylomeDBi | B9DGD6 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR032387, ACAS_N IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKIGSPSSPI LSVVSSSGSL DPKISGSLGS RILPATQRSS PSENLLLHRK
60 70 80 90 100
MSSNSLRHVE SMSQLPSGAG KISQLNAVVL GESLASEEND LVFPSKEFSG
110 120 130 140 150
QALVSSPQQY MEMHKRSMDD PAAFWSDIAS EFYWKQKWGD QVFSENLDVR
160 170 180 190 200
KGPISIEWFK GGITNICYNC LDKNVEAGLG DKTAIHWEGN ELGVDASLTY
210 220 230 240 250
SELLQRVCQL ANYLKDNGVK KGDAVVIYLP MLMELPIAML ACARIGAVHS
260 270 280 290 300
VVFAGFSADS LAQRIVDCKP NVILTCNAVK RGPKTINLKA IVDAALDQSS
310 320 330 340 350
KDGVSVGICL TYDNSLATTR ENTKWQNGRD VWWQDVISQY PTSCEVEWVD
360 370 380 390 400
AEDPLFLLYT SGSTGKPKGV LHTTGGYMIY TATTFKYAFD YKSTDVYWCT
410 420 430 440 450
ADCGWITGHS YVTYGPMLNG ATVVVFEGAP NYPDPGRCWD IVDKYKVSIF
460 470 480 490 500
YTAPTLVRSL MRDDDKFVTR HSRKSLRVLG SVGEPINPSA WRWFFNVVGD
510 520 530 540 550
SRCPISDTWW QTETGGFMIT PLPGAWPQKP GSATFPFFGV QPVIVDEKGN
560 570 580 590 600
EIEGECSGYL CVKGSWPGAF RTLFGDHERY ETTYFKPFAG YYFSGDGCSR
610 620 630 640 650
DKDGYYWLTG RVDDVINVSG HRIGTAEVES ALVLHPQCAE AAVVGIEHEV
660 670 680 690 700
KGQGIYAFVT LLEGVPYSEE LRKSLVLMVR NQIGAFAAPD RIHWAPGLPK
710 720 730 740
TRSGKIMRRI LRKIASRQLE ELGDTSTLAD PSVVDQLIAL ADV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8BCV2 | A0A1P8BCV2_ARATH | Acetyl-coenzyme A synthetase | ACS acetyl-CoA synthetase, At5g36880 | 610 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 426 | F → L in AAB92552 (PubMed:10859180).Curated | 1 | |
Sequence conflicti | 439 | W → R in AAB92552 (PubMed:10859180).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042326 | 1 – 50 | Missing in isoform 2. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036618 mRNA Translation: AAB92552.1 AB025605 Genomic DNA Translation: BAA98066.1 CP002688 Genomic DNA Translation: AED94120.1 CP002688 Genomic DNA Translation: AED94121.1 CP002688 Genomic DNA Translation: ANM69414.1 CP002688 Genomic DNA Translation: ANM69415.1 CP002688 Genomic DNA Translation: ANM69417.1 AY045880 mRNA Translation: AAK76554.1 BT002371 mRNA Translation: AAN86204.1 AK317115 mRNA Translation: BAH19803.1 |
RefSeqi | NP_001031974.2, NM_001036897.3 [B9DGD6-1] NP_001331094.1, NM_001344154.1 [B9DGD6-2] NP_001331095.1, NM_001344156.1 [B9DGD6-2] NP_001331097.1, NM_001344157.1 [B9DGD6-2] NP_198504.1, NM_123046.4 [B9DGD6-2] |
Genome annotation databases
EnsemblPlantsi | AT5G36880.1; AT5G36880.1; AT5G36880 [B9DGD6-2] AT5G36880.2; AT5G36880.2; AT5G36880 [B9DGD6-1] AT5G36880.3; AT5G36880.3; AT5G36880 [B9DGD6-2] AT5G36880.5; AT5G36880.5; AT5G36880 [B9DGD6-2] AT5G36880.6; AT5G36880.6; AT5G36880 [B9DGD6-2] |
GeneIDi | 833655 |
Gramenei | AT5G36880.1; AT5G36880.1; AT5G36880 [B9DGD6-2] AT5G36880.2; AT5G36880.2; AT5G36880 [B9DGD6-1] AT5G36880.3; AT5G36880.3; AT5G36880 [B9DGD6-2] AT5G36880.5; AT5G36880.5; AT5G36880 [B9DGD6-2] AT5G36880.6; AT5G36880.6; AT5G36880 [B9DGD6-2] |
KEGGi | ath:AT5G36880 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036618 mRNA Translation: AAB92552.1 AB025605 Genomic DNA Translation: BAA98066.1 CP002688 Genomic DNA Translation: AED94120.1 CP002688 Genomic DNA Translation: AED94121.1 CP002688 Genomic DNA Translation: ANM69414.1 CP002688 Genomic DNA Translation: ANM69415.1 CP002688 Genomic DNA Translation: ANM69417.1 AY045880 mRNA Translation: AAK76554.1 BT002371 mRNA Translation: AAN86204.1 AK317115 mRNA Translation: BAH19803.1 |
RefSeqi | NP_001031974.2, NM_001036897.3 [B9DGD6-1] NP_001331094.1, NM_001344154.1 [B9DGD6-2] NP_001331095.1, NM_001344156.1 [B9DGD6-2] NP_001331097.1, NM_001344157.1 [B9DGD6-2] NP_198504.1, NM_123046.4 [B9DGD6-2] |
3D structure databases
AlphaFoldDBi | B9DGD6 |
SMRi | B9DGD6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 18906, 4 interactors |
STRINGi | 3702.AT5G36880.2 |
PTM databases
iPTMneti | B9DGD6 |
MetOSitei | B9DGD6 |
Proteomic databases
PaxDbi | B9DGD6 |
PRIDEi | B9DGD6 |
ProteomicsDBi | 244386 [B9DGD6-1] |
Genome annotation databases
EnsemblPlantsi | AT5G36880.1; AT5G36880.1; AT5G36880 [B9DGD6-2] AT5G36880.2; AT5G36880.2; AT5G36880 [B9DGD6-1] AT5G36880.3; AT5G36880.3; AT5G36880 [B9DGD6-2] AT5G36880.5; AT5G36880.5; AT5G36880 [B9DGD6-2] AT5G36880.6; AT5G36880.6; AT5G36880 [B9DGD6-2] |
GeneIDi | 833655 |
Gramenei | AT5G36880.1; AT5G36880.1; AT5G36880 [B9DGD6-2] AT5G36880.2; AT5G36880.2; AT5G36880 [B9DGD6-1] AT5G36880.3; AT5G36880.3; AT5G36880 [B9DGD6-2] AT5G36880.5; AT5G36880.5; AT5G36880 [B9DGD6-2] AT5G36880.6; AT5G36880.6; AT5G36880 [B9DGD6-2] |
KEGGi | ath:AT5G36880 |
Organism-specific databases
Araporti | AT5G36880 |
TAIRi | locus:2149104, AT5G36880 |
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
InParanoidi | B9DGD6 |
OMAi | DHWWHDL |
OrthoDBi | 288915at2759 |
PhylomeDBi | B9DGD6 |
Enzyme and pathway databases
BioCyci | ARA:AT5G36880-MONOMER |
BRENDAi | 6.2.1.1, 399 |
Miscellaneous databases
PROi | PR:B9DGD6 |
Gene expression databases
ExpressionAtlasi | B9DGD6, baseline and differential |
Genevisiblei | B9DGD6, AT |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR011904, Ac_CoA_lig IPR032387, ACAS_N IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR02188, Ac_CoA_lig_AcsA, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACS_ARATH | |
Accessioni | B9DGD6Primary (citable) accession number: B9DGD6 Secondary accession number(s): O49063, Q9LTG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | March 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families