UniProtKB - B9DFX7 (HMA8_ARATH)

BLAST

>sp|B9DFX7|HMA8_ARATH Copper-transporting ATPase PAA2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=PAA2 PE=1 SV=1
MASNLLRFPLPPPSSLHIRPSKFLVNRCFPRLRRSRIRRHCSRPFFLVSNSVEISTQSFE
STESSIESVKSITSDTPILLDVSGMMCGGCVARVKSVLMSDDRVASAVVNMLTETAAVKF
KPEVEVTADTAESLAKRLTESGFEAKRRVSGMGVAENVKKWKEMVSKKEDLLVKSRNRVA
FAWTLVALCCGSHTSHILHSLGIHIAHGGIWDLLHNSYVKGGLAVGALLGPGRELLFDGI
KAFGKRSPNMNSLVGLGSMAAFSISLISLVNPELEWDASFFDEPVMLLGFVLLGRSLEER
AKLQASTDMNELLSLISTQSRLVITSSDNNTPVDSVLSSDSICINVSVDDIRVGDSLLVL
PGETFPVDGSVLAGRSVVDESMLTGESLPVFKEEGCSVSAGTINWDGPLRIKASSTGSNS
TISKIVRMVEDAQGNAAPVQRLADAIAGPFVYTIMSLSAMTFAFWYYVGSHIFPDVLLND
IAGPDGDALALSLKLAVDVLVVSCPCALGLATPTAILIGTSLGAKRGYLIRGGDVLERLA
SIDCVALDKTGTLTEGRPVVSGVASLGYEEQEVLKMAAAVEKTATHPIAKAIVNEAESLN
LKTPETRGQLTEPGFGTLAEIDGRFVAVGSLEWVSDRFLKKNDSSDMVKLESLLDHKLSN
TSSTSRYSKTVVYVGREGEGIIGAIAISDCLRQDAEFTVARLQEKGIKTVLLSGDREGAV
ATVAKNVGIKSESTNYSLSPEKKFEFISNLQSSGHRVAMVGDGINDAPSLAQADVGIALK
IEAQENAASNAASVILVRNKLSHVVDALSLAQATMSKVYQNLAWAIAYNVISIPIAAGVL
LPQYDFAMTPSLSGGLMALSSIFVVSNSLLLQLHKSETSKNSL

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History
Entry version 86 (25 Apr 2018)
Sequence version 1 (24 Mar 2009)
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Protein

Copper-transporting ATPase PAA2, chloroplastic

Gene

PAA2

Organism

Arabidopsis thaliana (Mouse-ear cress)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates copper transfer across the chloroplast thylakoid membrane. Required for copper delivery into the thylakoids lumen, which is essential for the function of copper proteins.1 Publication

Catalytic activityⁱ

ATP + H₂O + Cu²⁺(Side 1) = ADP + phosphate + Cu²⁺(Side 2).

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	87	CopperPROSITE-ProRule annotation	1
Metal bindingⁱ	90	CopperPROSITE-ProRule annotation	1
Active siteⁱ	548	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	762	MagnesiumPROSITE-ProRule annotation	1
Metal bindingⁱ	766	MagnesiumPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	761 – 768	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
copper-exporting ATPase activity Source: UniProtKB-EC
copper ion transmembrane transporter activity
Source: TAIR
Inferred from mutant phenotypeⁱ
- 15772282
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

copper ion transport
Source: TAIR
Inferred from mutant phenotypeⁱ
- 15772282

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Copper transport, Ion transport, Transport
Ligand	ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	ARA:AT5G21930-MONOMER MetaCyc:MONOMER-14496
BRENDAⁱ	3.6.3.4 399

Protein family/group databases

TCDBⁱ	3.A.3.5.12 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.5.12 the p-type atpase (p-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Copper-transporting ATPase PAA2, chloroplastic (EC:3.6.3.4) Alternative name(s): Protein HEAVY METAL ATPASE 8
Gene namesⁱ	Name:PAA2 Synonyms:HMA8 Ordered Locus Names:At5g21930 ORF Names:F13M11, T6G21
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT5G21930
TAIRⁱ	locus:504956435 AT5G21930

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	179 – 199	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	209 – 229	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	250 – 270	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	274 – 294	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	445 – 465	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	499 – 519	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	822 – 842	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	846 – 866	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechⁱ

Disruption phenotypeⁱ

High-chlorophyll-fluorescence phenotype.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 65	ChloroplastSequence analysisAdd BLAST		65
ChainⁱPRO_0000416858	66 – 883	Copper-transporting ATPase PAA2, chloroplasticAdd BLAST		818

Proteomic databases

PaxDbⁱ	B9DFX7
PRIDEⁱ	B9DFX7

Expressionⁱ

Tissue specificityⁱ

Expressed in the shoots only and not in the roots.1 Publication

Gene expression databases

ExpressionAtlasⁱ	B9DFX7 baseline and differential

ExpressionAtlasⁱ

B9DFX7 baseline and differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	3702.AT5G21930.1

STRINGⁱ

3702.AT5G21930.1

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	559 – 568	Combined sources	10
Helixⁱ	570 – 580	Combined sources	11
Turnⁱ	581 – 583	Combined sources	3
Helixⁱ	587 – 598	Combined sources	12
Beta strandⁱ	609 – 612	Combined sources	4
Turnⁱ	613 – 615	Combined sources	3
Beta strandⁱ	616 – 621	Combined sources	6
Beta strandⁱ	624 – 629	Combined sources	6
Helixⁱ	631 – 637	Combined sources	7
Helixⁱ	644 – 655	Combined sources	12
Beta strandⁱ	670 – 676	Combined sources	7
Turnⁱ	677 – 679	Combined sources	3
Beta strandⁱ	680 – 688	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	B9DFX7
SMRⁱ	B9DFX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	77 – 147	HMAPROSITE-ProRule annotationAdd BLAST		71

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]Curated

Keywords - Domainⁱ

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0207 Eukaryota COG2217 LUCA
HOGENOMⁱ	HOG000250397
InParanoidⁱ	B9DFX7
KEGG Orthology (KO) More...KOⁱ	K01533
OMAⁱ	ADSEHPV
Database of Orthologous Groups More...OrthoDBⁱ	EOG0936082Z
PhylomeDBⁱ	B9DFX7

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00371 HMA, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006121 HMA_dom IPR036163 HMA_dom_sf IPR027256 P-typ_ATPase_IB IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00403 HMA, 1 hit
SUPFAMⁱ	SSF55008 SSF55008, 1 hit SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 2 hits
TIGRFAMsⁱ	TIGR01525 ATPase-IB_hvy, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit PS50846 HMA_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform ⁱ produced by alternative splicing. Align Add to basket

Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: B9DFX7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNLLRFPL PPPSSLHIRP SKFLVNRCFP RLRRSRIRRH CSRPFFLVSN 
        60         70         80         90        100
SVEISTQSFE STESSIESVK SITSDTPILL DVSGMMCGGC VARVKSVLMS 
       110        120        130        140        150
DDRVASAVVN MLTETAAVKF KPEVEVTADT AESLAKRLTE SGFEAKRRVS 
       160        170        180        190        200
GMGVAENVKK WKEMVSKKED LLVKSRNRVA FAWTLVALCC GSHTSHILHS 
       210        220        230        240        250
LGIHIAHGGI WDLLHNSYVK GGLAVGALLG PGRELLFDGI KAFGKRSPNM 
       260        270        280        290        300
NSLVGLGSMA AFSISLISLV NPELEWDASF FDEPVMLLGF VLLGRSLEER 
       310        320        330        340        350
AKLQASTDMN ELLSLISTQS RLVITSSDNN TPVDSVLSSD SICINVSVDD 
       360        370        380        390        400
IRVGDSLLVL PGETFPVDGS VLAGRSVVDE SMLTGESLPV FKEEGCSVSA 
       410        420        430        440        450
GTINWDGPLR IKASSTGSNS TISKIVRMVE DAQGNAAPVQ RLADAIAGPF 
       460        470        480        490        500
VYTIMSLSAM TFAFWYYVGS HIFPDVLLND IAGPDGDALA LSLKLAVDVL 
       510        520        530        540        550
VVSCPCALGL ATPTAILIGT SLGAKRGYLI RGGDVLERLA SIDCVALDKT 
       560        570        580        590        600
GTLTEGRPVV SGVASLGYEE QEVLKMAAAV EKTATHPIAK AIVNEAESLN 
       610        620        630        640        650
LKTPETRGQL TEPGFGTLAE IDGRFVAVGS LEWVSDRFLK KNDSSDMVKL 
       660        670        680        690        700
ESLLDHKLSN TSSTSRYSKT VVYVGREGEG IIGAIAISDC LRQDAEFTVA 
       710        720        730        740        750
RLQEKGIKTV LLSGDREGAV ATVAKNVGIK SESTNYSLSP EKKFEFISNL 
       760        770        780        790        800
QSSGHRVAMV GDGINDAPSL AQADVGIALK IEAQENAASN AASVILVRNK 
       810        820        830        840        850
LSHVVDALSL AQATMSKVYQ NLAWAIAYNV ISIPIAAGVL LPQYDFAMTP 
       860        870        880 
SLSGGLMALS SIFVVSNSLL LQLHKSETSK NSL

Length:883

Mass (Da):94,260

Last modified:March 24, 2009 - v1

Checksum:ⁱF5E365AB6B7A90C3

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation
	Q9FV71	E2FB_ARATH	Transcription factor E2FB Transcription factor E2FB (E2F transcription factor-1, AtE2F1)	E2FB E2F1, At5g22220, T6G21	469	Annotation score:
	Q9C587	RFC1_ARATH	Replication factor C subunit 1 Replication factor C subunit 1, AtRFC1 (Activator 1 large subunit) (Activator 1 subunit 1)	RFC1 At5g22010, T6G21	956	Annotation score:
	Q84VQ3	CIPKQ_ARATH	CBL-interacting serine/threonine-pr... CBL-interacting serine/threonine-protein kinase 26, EC 2.7.11.1 (SNF1-related kinase 3.26) (SOS2-like protein kinase PKS26)	CIPK26 PKS26, SnRK3.26, At5g21326, F13M11	439	Annotation score:
	O81147	PSA6B_ARATH	Proteasome subunit alpha type-6-B Proteasome subunit alpha type-6-B, EC 3.4.25.1 (20S proteasome subunit alpha A-2) (Proteasome subunit alpha type-1)	PAA2 At2g05840, T6P5.4	246	Annotation score:
	Q9FUJ1	CKX7_ARATH	Cytokinin dehydrogenase 7 Cytokinin dehydrogenase 7, EC 1.5.99.12 (Cytokinin oxidase 7, AtCKX5, AtCKX7, CKO7)	CKX7 CKX5, At5g21482, F13M11	524	Annotation score:
	Q03509	CALM6_ARATH	Calmodulin-6 Calmodulin-6, CaM-6	CAM6 At5g21274, F13M11	149	Annotation score:
	Q8S9D1	PP395_ARATH	Pentatricopeptide repeat-containing... Pentatricopeptide repeat-containing protein At5g21222 (SNF1-like protein kinase AtC401)	ATC401 At5g21222, F13M11	831	Annotation score:
	F4IIA5	F4IIA5_ARATH	Proteasome subunit alpha type Proteasome subunit alpha type, EC 3.4.25.1	PAA2 20S proteasome subunit PAA2, At2g05840, T6P5.4, T6P5_4	220	Annotation score:
	A0A1P8B073	A0A1P8B073_ARATH	Proteasome subunit alpha type Proteasome subunit alpha type, EC 3.4.25.1	PAA2 20S proteasome subunit PAA2, At2g05840, T6P5.4, T6P5_4	205	Annotation score:
	F4K8C8	F4K8C8_ARATH	P-type ATPase of Arabidopsis 2 P-type ATPase of Arabidopsis 2	PAA2 ATHMA8, HEAVY METAL ATPASE 8, HMA8, P-type ATPase of Arabidopsis 2, At5g21930	860	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAO73891 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAC34486 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	312	L → P in AAP55720 (PubMed:15772282).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY297817 mRNA Translation: AAP55720.1 AC140977 Genomic DNA Translation: AAO73891.1 Sequence problems. AL589883 Genomic DNA Translation: CAC34486.1 Sequence problems. CP002688 Genomic DNA Translation: AED92956.1 CP002688 Genomic DNA Translation: AED92957.1 AK316941 mRNA Translation: BAH19644.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001031920.1, NM_001036843.1 [B9DFX7-1] NP_680181.2, NM_147876.5 [B9DFX7-1]
UniGeneⁱ	At.44341

Genome annotation databases

EnsemblPlantsⁱ	AT5G21930.1; AT5G21930.1; AT5G21930 [B9DFX7-1] AT5G21930.2; AT5G21930.2; AT5G21930 [B9DFX7-1]
GeneIDⁱ	832253
Grameneⁱ	AT5G21930.1; AT5G21930.1; AT5G21930 [B9DFX7-1] AT5G21930.2; AT5G21930.2; AT5G21930 [B9DFX7-1]
KEGGⁱ	ath:AT5G21930

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B9DFX7	Uncharacterized protein		Capsella rubella		888	UniRef90_B9DFX7
Uncharacterized protein		ARALL		887
Copper-transporting ATPase PAA2, chloroplastic		NOCCA		886
Uncharacterized protein		EUTSA		886
Uncharacterized protein		BRARP		885
+12

Protein	Similar proteins		Species	Score	Length	Source
B9DFX7	Uncharacterized protein		Capsella rubella		888	UniRef50_B9DFX7
Uncharacterized protein		ARALL		887
Copper-transporting ATPase PAA2, chloroplastic		NOCCA		886
Uncharacterized protein		EUTSA		886
BnaC09g36680D protein		BRANA		885
+156

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY297817 mRNA Translation: AAP55720.1 AC140977 Genomic DNA Translation: AAO73891.1 Sequence problems. AL589883 Genomic DNA Translation: CAC34486.1 Sequence problems. CP002688 Genomic DNA Translation: AED92956.1 CP002688 Genomic DNA Translation: AED92957.1 AK316941 mRNA Translation: BAH19644.1
RefSeqⁱ	NP_001031920.1, NM_001036843.1 [B9DFX7-1] NP_680181.2, NM_147876.5 [B9DFX7-1]
UniGeneⁱ	At.44341

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5LBK	X-ray	1.75	A/B	557-689	[»]
ProteinModelPortalⁱ	B9DFX7
SMRⁱ	B9DFX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	3702.AT5G21930.1

STRINGⁱ

3702.AT5G21930.1

Protein family/group databases

TCDBⁱ	3.A.3.5.12 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.5.12 the p-type atpase (p-atpase) superfamily

Proteomic databases

PaxDbⁱ	B9DFX7
PRIDEⁱ	B9DFX7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT5G21930.1; AT5G21930.1; AT5G21930 [B9DFX7-1] AT5G21930.2; AT5G21930.2; AT5G21930 [B9DFX7-1]
GeneIDⁱ	832253
Grameneⁱ	AT5G21930.1; AT5G21930.1; AT5G21930 [B9DFX7-1] AT5G21930.2; AT5G21930.2; AT5G21930 [B9DFX7-1]
KEGGⁱ	ath:AT5G21930

Organism-specific databases

Araportⁱ	AT5G21930
TAIRⁱ	locus:504956435 AT5G21930

Phylogenomic databases

eggNOGⁱ	KOG0207 Eukaryota COG2217 LUCA
HOGENOMⁱ	HOG000250397
InParanoidⁱ	B9DFX7
KOⁱ	K01533
OMAⁱ	ADSEHPV
OrthoDBⁱ	EOG0936082Z
PhylomeDBⁱ	B9DFX7

Enzyme and pathway databases

BioCycⁱ	ARA:AT5G21930-MONOMER MetaCyc:MONOMER-14496
BRENDAⁱ	3.6.3.4 399

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B9DFX7

PROⁱ

PR:B9DFX7

Gene expression databases

ExpressionAtlasⁱ	B9DFX7 baseline and differential

ExpressionAtlasⁱ

B9DFX7 baseline and differential

Family and domain databases

CDDⁱ	cd00371 HMA, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006121 HMA_dom IPR036163 HMA_dom_sf IPR027256 P-typ_ATPase_IB IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00403 HMA, 1 hit
SUPFAMⁱ	SSF55008 SSF55008, 1 hit SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 2 hits
TIGRFAMsⁱ	TIGR01525 ATPase-IB_hvy, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit PS50846 HMA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMA8_ARATH
Accessionⁱ	B9DFX7Primary (citable) accession number: B9DFX7 Secondary accession number(s): Q7Y051, Q9C594
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2012
	Last sequence update:	March 24, 2009
	Last modified:	April 25, 2018
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9DFX7 (HMA8_ARATH)

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Copper-transporting ATPase PAA2, chloroplastic

PAA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Chloroplast

Chloroplast

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ