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Protein

Shikimate kinase

Gene

aroK

Organism
Burkholderia multivorans CGD1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (BURMUCGD1_1524), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG), Phospho-2-dehydro-3-deoxyheptonate aldolase (BURMUCGD1_5671)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumUniRule annotation1
Binding sitei65SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei111Substrate; via amide nitrogenUniRule annotation1
Binding sitei149ATPUniRule annotation1
Binding sitei168SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 48ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotationSAAS annotation (EC:2.7.1.71UniRule annotationSAAS annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotationImported
ORF Names:BURMUCGD1_3148Imported
OrganismiBurkholderia multivorans CGD1Imported
Taxonomic identifieri513051 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000005493 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB9BA12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H02J5

Family and domain databases

CDDicd00464 SK, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR023000 Shikimate_kinase_CS
PfamiView protein in Pfam
PF01202 SKI, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01128 SHIKIMATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B9BA12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQARQGSRF ASKLRHTPAR LKQRKPLQAR DPHANVFFVG LMGAGKTTVG
60 70 80 90 100
RAVARRLDRT FFDSDHEIEA RTGARIPVIF ELEGEAGFRD REAQMIAELT
110 120 130 140 150
QRENIVLATG GGAVLRAENR ACLKGNGIVV YLRANPHDLW LRTRKDKNRP
160 170 180 190 200
LLQTDDPKAR LEALYEVRDP LYRECADFVI ETGRPSVNGL VNMVLMQLEL
210
AGVVAKPLQA
Length:210
Mass (Da):23,481
Last modified:March 24, 2009 - v1
Checksum:iC0E21A04DC164569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFB01000007 Genomic DNA Translation: EED99375.1

Genome annotation databases

EnsemblBacteriaiEED99375; EED99375; BURMUCGD1_3148

Similar proteinsi

Entry informationi

Entry nameiB9BA12_9BURK
AccessioniPrimary (citable) accession number: B9BA12
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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