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Protein
Submitted name:

RUN and TBC1 domain-containing protein 3

Gene

RUTBC3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
RUN and TBC1 domain-containing protein 3Imported
Gene namesi
Name:RUTBC3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000100359.20

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403194

PTM / Processingi

Proteomic databases

PRIDEiB9A6J5

Expressioni

Gene expression databases

BgeeiENSG00000100359 Expressed in 222 organ(s), highest expression level in body of stomach
ExpressionAtlasiB9A6J5 baseline and differential
GenevisibleiB9A6J5 HS

Structurei

3D structure databases

ProteinModelPortaliB9A6J5
SMRiB9A6J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 305Rab-GAP TBCInterPro annotationAdd BLAST192
Domaini480 – 539SH3InterPro annotationAdd BLAST60
Domaini555 – 718RUNInterPro annotationAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili418 – 438Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2222 Eukaryota
COG5210 LUCA
HOVERGENiHBG108484
KOiK20176
OMAiNSPGWVQ
OrthoDBiEOG091G02H8
PhylomeDBiB9A6J5

Family and domain databases

CDDicd11813 SH3_SGSM3, 1 hit
InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR035833 SGSM3_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF02759 RUN, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF47923 SSF47923, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

B9A6J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSHTPACG PFSALTPSIW PQEILAKYTQ KEESAEQPEF YYDEFGFRVY
60 70 80 90 100
KEEGDEPGSS LLANSPLMED APQRLRWQAH LEFTHNHDVG DLTWDKIAVS
110 120 130 140 150
LPRSEKLRSL VLAGIPHGMR PQLWMRLSGA LQKKRNSELS YREIVKNSSN
160 170 180 190 200
DETIAAKQIE KDLLRTMPSN ACFASMGSIG VPRLRRVLRA LAWLYPEIGY
210 220 230 240 250
CQGTGMVAAC LLLFLEEEDA FWMMSAIIED LLPASYFSTT LLGVQTDQRV
260 270 280 290 300
LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVD IKLLLRIWDL
310 320 330 340 350
FFYEGSRVLF QLTLGMLHLK EEELIQSENS ASIFNTLSDI PSQMEDAELL
360 370 380 390 400
LGVAMRLAGS LTDVAVETQR RKHLAYLIAD QGQLLGAGTL TNLSQVVRRR
410 420 430 440 450
TQRRKSTITA LLFGEDDLEA LKAKNIKQTE LVADLREAIL RVARHFQCTD
460 470 480 490 500
PKNCSVELTP DYSMESHQRD HENYVACSRS HRRRAKALLD FERHDDDELG
510 520 530 540 550
FRKNDIITIV SQKDEHCWVG ELNGLRGWFP AKFVEVLDER SKEYSIAGDD
560 570 580 590 600
SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV
610 620 630 640 650
ERDFASVYSR LVLCKTFRLD EDGKVLTPEE LLYRAVQSVN VTHDAVHAQM
660 670 680 690 700
DVKLRSLICV GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK
710 720 730 740
CELRVLCCFA FSLSQDWELP AKREAQQPLK EGVRDMLVKH HLFSWDVDG
Length:749
Mass (Da):85,354
Last modified:March 24, 2009 - v1
Checksum:i3DA4F7961EF79056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449880 mRNA Translation: BAH16623.1
RefSeqiNP_056520.2, NM_015705.5
UniGeneiHs.474914

Genome annotation databases

GeneIDi27352
KEGGihsa:27352

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449880 mRNA Translation: BAH16623.1
RefSeqiNP_056520.2, NM_015705.5
UniGeneiHs.474914

3D structure databases

ProteinModelPortaliB9A6J5
SMRiB9A6J5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB9A6J5

Protocols and materials databases

DNASUi27352
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27352
KEGGihsa:27352

Organism-specific databases

CTDi27352
EuPathDBiHostDB:ENSG00000100359.20
PharmGKBiPA162403194

Phylogenomic databases

eggNOGiKOG2222 Eukaryota
COG5210 LUCA
HOVERGENiHBG108484
KOiK20176
OMAiNSPGWVQ
OrthoDBiEOG091G02H8
PhylomeDBiB9A6J5

Miscellaneous databases

ChiTaRSiSGSM3 human
GenomeRNAii27352

Gene expression databases

BgeeiENSG00000100359 Expressed in 222 organ(s), highest expression level in body of stomach
ExpressionAtlasiB9A6J5 baseline and differential
GenevisibleiB9A6J5 HS

Family and domain databases

CDDicd11813 SH3_SGSM3, 1 hit
InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR035833 SGSM3_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF02759 RUN, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF47923 SSF47923, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB9A6J5_HUMAN
AccessioniPrimary (citable) accession number: B9A6J5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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