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Protein

Immunoglobulin lambda-like polypeptide 5

Gene

IGLL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 5
Alternative name(s):
G lambda-1
Germline immunoglobulin lambda 1
Gene namesi
Name:IGLL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000254709.7
HGNCiHGNC:38476 IGLL5
neXtProtiNX_B9A064

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi100423062
OpenTargetsiENSG00000254709

Polymorphism and mutation databases

BioMutaiIGLL5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000040559636 – 214Immunoglobulin lambda-like polypeptide 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiB9A064
PaxDbiB9A064
PRIDEiB9A064
ProteomicsDBi7509
7510 [B9A064-2]

PTM databases

CarbonylDBiB9A064
iPTMnetiB9A064
PhosphoSitePlusiB9A064

Expressioni

Tissue specificityi

Contrary to IGLL1, not expressed in pre-B-cells.2 Publications

Gene expression databases

BgeeiENSG00000254709 Expressed in 82 organ(s), highest expression level in lymph node
ExpressionAtlasiB9A064 baseline and differential
GenevisibleiB9A064 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1148096, 24 interactors
IntActiB9A064, 1 interactor
MINTiB9A064
STRINGi9606.ENSP00000431254

Structurei

3D structure databases

ProteinModelPortaliB9A064
SMRiB9A064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 209Ig-like C1-typeAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 109J region (By similarity to lambda light-chain)Add BLAST12
Regioni110 – 214C region (By similarity to lambda light-chain)Add BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J0XA Eukaryota
ENOG410YZ00 LUCA
GeneTreeiENSGT00730000110696
HOVERGENiHBG108319
InParanoidiB9A064
PhylomeDBiB9A064
TreeFamiTF335549

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: B9A064-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP
60 70 80 90 100
DPGASVGSSR SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG
110 120 130 140 150
TGTKVTVLGQ PKANPTVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW
160 170 180 190 200
KADGSPVKAG VETTKPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE
210
GSTVEKTVAP TECS
Note: No experimental confirmation available.
Length:214
Mass (Da):23,063
Last modified:March 8, 2011 - v2
Checksum:iA29B29F09C063EBC
GO
Isoform 2 (identifier: B9A064-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: LLLQPSPQRADPRCW → SAQGQPHCHSVPALL
     85-214: Missing.

Show »
Length:84
Mass (Da):8,843
Checksum:i668BAC17435C50E8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J231A0A0B4J231_HUMAN
Immunoglobulin lambda-like polypept...
IGLL5
215Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04070970 – 84LLLQP…DPRCW → SAQGQPHCHSVPALL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_04071085 – 214Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA No translation available.
CCDSiCCDS54506.1 [B9A064-1]
RefSeqiNP_001171597.1, NM_001178126.1 [B9A064-1]
UniGeneiHs.449574
Hs.449585
Hs.474325
Hs.535668
Hs.625768
Hs.640434
Hs.659929
Hs.713252
Hs.728722
Hs.728758
Hs.731137

Genome annotation databases

EnsembliENST00000526893; ENSP00000431254; ENSG00000254709 [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709 [B9A064-2]
GeneIDi100423062
KEGGihsa:100423062
UCSCiuc011aiw.3 human [B9A064-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87023 Genomic DNA No translation available.
CCDSiCCDS54506.1 [B9A064-1]
RefSeqiNP_001171597.1, NM_001178126.1 [B9A064-1]
UniGeneiHs.449574
Hs.449585
Hs.474325
Hs.535668
Hs.625768
Hs.640434
Hs.659929
Hs.713252
Hs.728722
Hs.728758
Hs.731137

3D structure databases

ProteinModelPortaliB9A064
SMRiB9A064
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1148096, 24 interactors
IntActiB9A064, 1 interactor
MINTiB9A064
STRINGi9606.ENSP00000431254

PTM databases

CarbonylDBiB9A064
iPTMnetiB9A064
PhosphoSitePlusiB9A064

Polymorphism and mutation databases

BioMutaiIGLL5

Proteomic databases

MaxQBiB9A064
PaxDbiB9A064
PRIDEiB9A064
ProteomicsDBi7509
7510 [B9A064-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526893; ENSP00000431254; ENSG00000254709 [B9A064-1]
ENST00000531372; ENSP00000434368; ENSG00000254709 [B9A064-2]
GeneIDi100423062
KEGGihsa:100423062
UCSCiuc011aiw.3 human [B9A064-1]

Organism-specific databases

CTDi100423062
DisGeNETi100423062
EuPathDBiHostDB:ENSG00000254709.7
GeneCardsiIGLL5
HGNCiHGNC:38476 IGLL5
neXtProtiNX_B9A064
OpenTargetsiENSG00000254709
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XA Eukaryota
ENOG410YZ00 LUCA
GeneTreeiENSGT00730000110696
HOVERGENiHBG108319
InParanoidiB9A064
PhylomeDBiB9A064
TreeFamiTF335549

Miscellaneous databases

ChiTaRSiIGLL5 human
GenomeRNAii100423062
PROiPR:B9A064

Gene expression databases

BgeeiENSG00000254709 Expressed in 82 organ(s), highest expression level in lymph node
ExpressionAtlasiB9A064 baseline and differential
GenevisibleiB9A064 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGLL5_HUMAN
AccessioniPrimary (citable) accession number: B9A064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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