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Protein
Submitted name:

Unconventional myosin-VIIa

Gene

MYO7A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIIaImported
Gene namesi
Name:MYO7AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137474.19
HGNCiHGNC:7606 MYO7A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137474
PharmGKBiPA31411

PTM / Processingi

Proteomic databases

PRIDEiB9A012

Expressioni

Gene expression databases

BgeeiENSG00000137474

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB9A012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96Myosin motorInterPro annotationAdd BLAST96
Domaini372 – 533MyTH4InterPro annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 290Sequence analysisAdd BLAST69

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000090009
HOVERGENiHBG107076

Family and domain databases

Gene3Di1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001609 Myosin_head_motor_dom
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 4 hits
PF00063 Myosin_head, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 4 hits
SM00139 MyTH4, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit

Sequencei

Sequence statusi: Fragment.

B9A012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LFDRHLCVRQ LRYSGMMETI RIRRAGYPIR YSFVEFVERY RVLLPGVKPA
60 70 80 90 100
YKQGDLRGTC QRMAEAVLGT HDDWQIGKTK IFLKDHHDML LEVERDKAIT
110 120 130 140 150
DRVILLQKVI RGFKDRSNFL KLKNAATLIQ RHWRGHNCRK NYGLMRLGFL
160 170 180 190 200
RLQALHRSRK LHQQYRLARQ RIIQFQARCR AYLVRKAFRH RLWAVLTVQA
210 220 230 240 250
YARGMIARRL HQRLRAEYLW RLEAEKMRLA EEEKLRKEMS AKKAKEEAER
260 270 280 290 300
KHQERLAQLA REDAERELKE KEAARRKKEL LEQMERARHE PVNHSDMVDK
310 320 330 340 350
MFGFLGTSGG LPGQEGQAPS GFEDLERGRR EMVEEDLDAA LPLPDEDEED
360 370 380 390 400
LSEYKFAKFA ATYFQGTTTH SYTRRPLKQP LLYHDDEGDQ LAALAVWITI
410 420 430 440 450
LRFMGDLPEP KYHTAMSDGS EKIPVMTKIY ETLGKKTYKR ELQALQGEGE
460 470 480 490 500
AQLPEGQKKS SVRHKLVHLT LKKKSKLTEE VTKRLHDGES TVQGNSMLED
510 520 530
RPTSNLEKLH FIIGNGILRP ALRSVPGGGD TRA
Length:533
Mass (Da):62,185
Last modified:June 20, 2018 - v2
Checksum:iEA13DF352887868E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000752 Genomic DNA No translation available.
AP001855 Genomic DNA No translation available.
KF511157 Genomic DNA No translation available.
UniGeneiHs.370421

Genome annotation databases

EnsembliENST00000409893; ENSP00000386689; ENSG00000137474
UCSCiuc010rsl.3 human

Similar proteinsi

Entry informationi

Entry nameiB9A012_HUMAN
AccessioniPrimary (citable) accession number: B9A012
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: June 20, 2018
Last modified: July 18, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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