UniProtKB - B9A012 (B9A012_HUMAN)
Protein
Submitted name:
Unconventional myosin-VIIa
Gene
MYO7A
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ATP binding Source: InterPro
- motor activity Source: InterPro
Keywordsi
Molecular function | Actin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Unconventional myosin-VIIaImported |
Gene namesi | Name:MYO7AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7606, MYO7A |
VEuPathDBi | HostDB:ENSG00000137474.19 |
Subcellular locationi
Cytoskeleton
- myosin complex Source: UniProtKB-KW
Cytosol
- cytosol Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000137474, Expressed in right adrenal gland and 165 other tissues |
ExpressionAtlasi | B9A012, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 96 | Myosin motorInterPro annotationAdd BLAST | 96 | |
Domaini | 372 – 533 | MyTH4InterPro annotationAdd BLAST | 162 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 222 – 290 | Sequence analysisAdd BLAST | 69 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155350 |
HOGENOMi | CLU_000192_7_3_1 |
OrthoDBi | 527681at2759 |
Family and domain databases
Gene3Di | 1.25.40.530, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR001609, Myosin_head_motor_dom IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 4 hits PF00063, Myosin_head, 1 hit |
SMARTi | View protein in SMART SM00015, IQ, 4 hits SM00139, MyTH4, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50096, IQ, 3 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
B9A012-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LFDRHLCVRQ LRYSGMMETI RIRRAGYPIR YSFVEFVERY RVLLPGVKPA
60 70 80 90 100
YKQGDLRGTC QRMAEAVLGT HDDWQIGKTK IFLKDHHDML LEVERDKAIT
110 120 130 140 150
DRVILLQKVI RGFKDRSNFL KLKNAATLIQ RHWRGHNCRK NYGLMRLGFL
160 170 180 190 200
RLQALHRSRK LHQQYRLARQ RIIQFQARCR AYLVRKAFRH RLWAVLTVQA
210 220 230 240 250
YARGMIARRL HQRLRAEYLW RLEAEKMRLA EEEKLRKEMS AKKAKEEAER
260 270 280 290 300
KHQERLAQLA REDAERELKE KEAARRKKEL LEQMERARHE PVNHSDMVDK
310 320 330 340 350
MFGFLGTSGG LPGQEGQAPS GFEDLERGRR EMVEEDLDAA LPLPDEDEED
360 370 380 390 400
LSEYKFAKFA ATYFQGTTTH SYTRRPLKQP LLYHDDEGDQ LAALAVWITI
410 420 430 440 450
LRFMGDLPEP KYHTAMSDGS EKIPVMTKIY ETLGKKTYKR ELQALQGEGE
460 470 480 490 500
AQLPEGQKKS SVRHKLVHLT LKKKSKLTEE VTKRLHDGES TVQGNSMLED
510 520 530
RPTSNLEKLH FIIGNGILRP ALRSVPGGGD TRA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13402 | MYO7A_HUMAN | Unconventional myosin-VIIa | MYO7A USH1B | 2,215 | Annotation score: | ||
A0A087WT71 | A0A087WT71_HUMAN | Unconventional myosin-VIIa | MYO7A | 1,198 | Annotation score: | ||
H7C4D8 | H7C4D8_HUMAN | Unconventional myosin-VIIa | MYO7A | 1,357 | Annotation score: | ||
A0A590UJR8 | A0A590UJR8_HUMAN | Unconventional myosin-VIIa | MYO7A | 100 | Annotation score: | ||
A0A590UJ94 | A0A590UJ94_HUMAN | Unconventional myosin-VIIa | MYO7A | 1,076 | Annotation score: | ||
A0A590UJG0 | A0A590UJG0_HUMAN | Unconventional myosin-VIIa | MYO7A | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000752 Genomic DNA No translation available. AP001855 Genomic DNA No translation available. KF511157 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000409893; ENSP00000386689; ENSG00000137474 |
UCSCi | uc010rsl.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000752 Genomic DNA No translation available. AP001855 Genomic DNA No translation available. KF511157 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B9A012 |
PRIDEi | B9A012 |
ProteomicsDBi | 7478 |
Protocols and materials databases
Antibodypediai | 31226, 182 antibodies |
DNASUi | 4647 |
Genome annotation databases
Ensembli | ENST00000409893; ENSP00000386689; ENSG00000137474 |
UCSCi | uc010rsl.3, human |
Organism-specific databases
HGNCi | HGNC:7606, MYO7A |
OpenTargetsi | ENSG00000137474 |
PharmGKBi | PA31411 |
VEuPathDBi | HostDB:ENSG00000137474.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155350 |
HOGENOMi | CLU_000192_7_3_1 |
OrthoDBi | 527681at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4647, 6 hits in 874 CRISPR screens |
ChiTaRSi | MYO7A, human |
GenomeRNAii | 4647 |
Gene expression databases
Bgeei | ENSG00000137474, Expressed in right adrenal gland and 165 other tissues |
ExpressionAtlasi | B9A012, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.530, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR001609, Myosin_head_motor_dom IPR000857, MyTH4_dom IPR038185, MyTH4_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00612, IQ, 4 hits PF00063, Myosin_head, 1 hit |
SMARTi | View protein in SMART SM00015, IQ, 4 hits SM00139, MyTH4, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50096, IQ, 3 hits PS51456, MYOSIN_MOTOR, 1 hit PS51016, MYTH4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B9A012_HUMAN | |
Accessioni | B9A012Primary (citable) accession number: B9A012 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | June 20, 2018 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |