MYO7A

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

actin filament binding Source: InterPro
ATP binding Source: UniProtKB-UniRule
microtubule binding Source: InterPro
microtubule motor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule-based movement Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation

Molecular function

Actin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Unconventional myosin-VIIaImported
Gene namesⁱ	Name:MYO7AImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137474.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7606 MYO7A

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000137474
PharmGKBⁱ	PA31411

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	B9A012

PRIDEⁱ

B9A012

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137474

Bgeeⁱ

ENSG00000137474

Interactionⁱ

GO - Molecular functionⁱ

actin filament binding Source: InterPro
microtubule binding Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	B9A012
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 96	Myosin motorInterPro annotationAdd BLAST		96
Domainⁱ	372 – 533	MyTH4InterPro annotationAdd BLAST		162

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	222 – 290	Sequence analysisAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4229 Eukaryota COG5022 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140810
HOGENOMⁱ	HOG000090009
HOVERGENⁱ	HBG107076

Family and domain databases

Gene3Dⁱ	1.25.40.530, 1 hit
InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR001609 Myosin_head_motor_dom IPR000857 MyTH4_dom IPR038185 MyTH4_dom_sf IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612 IQ, 4 hits PF00063 Myosin_head, 1 hit
SMARTⁱ	View protein in SMART SM00015 IQ, 4 hits SM00139 MyTH4, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 3 hits PS51456 MYOSIN_MOTOR, 1 hit PS51016 MYTH4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

B9A012-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
LFDRHLCVRQ LRYSGMMETI RIRRAGYPIR YSFVEFVERY RVLLPGVKPA 
        60         70         80         90        100
YKQGDLRGTC QRMAEAVLGT HDDWQIGKTK IFLKDHHDML LEVERDKAIT 
       110        120        130        140        150
DRVILLQKVI RGFKDRSNFL KLKNAATLIQ RHWRGHNCRK NYGLMRLGFL 
       160        170        180        190        200
RLQALHRSRK LHQQYRLARQ RIIQFQARCR AYLVRKAFRH RLWAVLTVQA 
       210        220        230        240        250
YARGMIARRL HQRLRAEYLW RLEAEKMRLA EEEKLRKEMS AKKAKEEAER 
       260        270        280        290        300
KHQERLAQLA REDAERELKE KEAARRKKEL LEQMERARHE PVNHSDMVDK 
       310        320        330        340        350
MFGFLGTSGG LPGQEGQAPS GFEDLERGRR EMVEEDLDAA LPLPDEDEED 
       360        370        380        390        400
LSEYKFAKFA ATYFQGTTTH SYTRRPLKQP LLYHDDEGDQ LAALAVWITI 
       410        420        430        440        450
LRFMGDLPEP KYHTAMSDGS EKIPVMTKIY ETLGKKTYKR ELQALQGEGE 
       460        470        480        490        500
AQLPEGQKKS SVRHKLVHLT LKKKSKLTEE VTKRLHDGES TVQGNSMLED 
       510        520        530 
RPTSNLEKLH FIIGNGILRP ALRSVPGGGD TRA

Length:533

Mass (Da):62,185

Last modified:June 20, 2018 - v2

Checksum:ⁱEA13DF352887868E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP000752 Genomic DNA No translation available. AP001855 Genomic DNA No translation available. KF511157 Genomic DNA No translation available.
UniGeneⁱ	Hs.370421

Genome annotation databases

Ensemblⁱ	ENST00000409893; ENSP00000386689; ENSG00000137474
UCSC genome browser More...UCSCⁱ	uc010rsl.3 human

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
B9A012	UPI000529AB15		COLST		548
Myosin-VIIa-like (Fragment)		Tropilaelaps mercedesae		555
Myosin VIIA, putative (Fragment)		FUNHE		642

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP000752 Genomic DNA No translation available. AP001855 Genomic DNA No translation available. KF511157 Genomic DNA No translation available.
UniGeneⁱ	Hs.370421

3D structure databases

SMRⁱ	B9A012
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	B9A012

PRIDEⁱ

B9A012

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4647
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000409893; ENSP00000386689; ENSG00000137474
UCSC genome browser More...UCSCⁱ	uc010rsl.3 human

Organism-specific databases

CTDⁱ	4647
EuPathDBⁱ	HostDB:ENSG00000137474.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7606 MYO7A
Open Targets More...OpenTargetsⁱ	ENSG00000137474
PharmGKBⁱ	PA31411
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4229 Eukaryota COG5022 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140810
HOGENOMⁱ	HOG000090009
HOVERGENⁱ	HBG107076

Miscellaneous databases

ChiTaRSⁱ	MYO7A human
GenomeRNAiⁱ	4647

Gene expression databases

Bgeeⁱ	ENSG00000137474

Bgeeⁱ

ENSG00000137474

Family and domain databases

Gene3Dⁱ	1.25.40.530, 1 hit
InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR001609 Myosin_head_motor_dom IPR000857 MyTH4_dom IPR038185 MyTH4_dom_sf IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612 IQ, 4 hits PF00063 Myosin_head, 1 hit
SMARTⁱ	View protein in SMART SM00015 IQ, 4 hits SM00139 MyTH4, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 3 hits PS51456 MYOSIN_MOTOR, 1 hit PS51016 MYTH4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B9A012_HUMAN
Accessionⁱ	B9A012Primary (citable) accession number: B9A012
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 3, 2009
	Last sequence update:	June 20, 2018
	Last modified:	July 18, 2018
	This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9A012 (B9A012_HUMAN)

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Unconventional myosin-VIIa

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ