UniProtKB - B8ZZZ4 (B8ZZZ4_HUMAN)
Protein
T-cell surface glycoprotein CD8 alpha chain
Gene
CD8A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD8 alpha chainARBA annotation |
Gene namesi | Name:CD8AImported ORF Names:hCG_34192Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1706, CD8A |
VEuPathDBi | HostDB:ENSG00000153563.15 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 146 – 169 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5014085789 | 22 – 198 | T-cell surface glycoprotein CD8 alpha chainSequence analysisAdd BLAST | 177 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | B8ZZZ4 |
ProteomicsDBi | 7468 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153563, Expressed in thymus and 175 other tissues |
ExpressionAtlasi | B8ZZZ4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 117 | Ig-likeInterPro annotationAdd BLAST | 97 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156588 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015468, CD8_asu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR10441, PTHR10441, 2 hits |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B8ZZZ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP
60 70 80 90 100
TSGCSWLFQP RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL
110 120 130 140 150
TLSDFRRENE GYYFCSALSN SIMYFSHFVP VFLPVHTRGL DFACDIYIWA
160 170 180 190
PLAGTCGVLL LSLVITLYCN HRNRRRVCKC PRPVVKSGDK PSLSARYV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP01732 | CD8A_HUMAN | T-cell surface glycoprotein CD8 alp... | CD8A MAL | 235 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC064848 Genomic DNA No translation available. AC112696 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99441.1 |
Genome annotation databases
Ensembli | ENST00000409781; ENSP00000387314; ENSG00000153563 |
UCSCi | uc061lns.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC064848 Genomic DNA No translation available. AC112696 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99441.1 |
3D structure databases
SMRi | B8ZZZ4 |
ModBasei | Search... |
Proteomic databases
PRIDEi | B8ZZZ4 |
ProteomicsDBi | 7468 |
Protocols and materials databases
Antibodypediai | 3495, 5073 antibodies |
Genome annotation databases
Ensembli | ENST00000409781; ENSP00000387314; ENSG00000153563 |
UCSCi | uc061lns.1, human |
Organism-specific databases
HGNCi | HGNC:1706, CD8A |
OpenTargetsi | ENSG00000153563 |
VEuPathDBi | HostDB:ENSG00000153563.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156588 |
Miscellaneous databases
ChiTaRSi | CD8A, human |
Gene expression databases
Bgeei | ENSG00000153563, Expressed in thymus and 175 other tissues |
ExpressionAtlasi | B8ZZZ4, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015468, CD8_asu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR10441, PTHR10441, 2 hits |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B8ZZZ4_HUMAN | |
Accessioni | B8ZZZ4Primary (citable) accession number: B8ZZZ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |