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Protein
Submitted name:

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_a

Gene

MPP6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_aImported
Gene namesi
Name:MPP6Imported
ORF Names:hCG_38837Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105926.15
HGNCiHGNC:18167 MPP6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105926

PTM / Processingi

Proteomic databases

EPDiB8ZZG1
MaxQBiB8ZZG1
PRIDEiB8ZZG1

Expressioni

Gene expression databases

BgeeiENSG00000105926 Expressed in 136 organ(s), highest expression level in testis

Structurei

3D structure databases

SMRiB8ZZG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 97PDZInterPro annotationAdd BLAST80
Domaini103 – 172SH3InterPro annotationAdd BLAST70
Domaini226 – 413Guanylate kinase-likeInterPro annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili398 – 418Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858

Family and domain databases

CDDicd12038 SH3_MPP6, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR035603 MPP6_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

B8ZZG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNSSINNQL LPVDAIRILG IHKRAGEPLG VTFRVENNDL VIARILHGGM
60 70 80 90 100
IDRQGLLHVG DIIKEVNGHE VGNNPKELQE LLKNISGSVT LKILPSYRDT
110 120 130 140 150
ITPQQVFVKC HFDYNPYNDN LIPCKEAGLK FSKGEILQIV NREDPNWWQA
160 170 180 190 200
SHVKEGGSAG LIPSQFLEEK RKAFVRRDWD NSGPFCGTIS SKKKKKMMYL
210 220 230 240 250
TTRNAEFDRH EIQIYEEVAK MPPFQRKTLV LIGAQGVGRR SLKNRFIVLN
260 270 280 290 300
PTRFGTTVPF TSRKPREDEK DGQAYKFVSR SEMEADIKAG KYLEHGEYEG
310 320 330 340 350
NLYGTKIDSI LEVVQTGRTC ILDVNPQALK VLRTSEFMPY VVFIAAPELE
360 370 380 390 400
TLRAMHKAVV DAGITTKLLT DSDLKKTVDE SARIQRAYNH YFDLIIINDN
410 420
LDKAFEKLQT AIEKLRMEPQ WVPISWVY
Length:428
Mass (Da):48,758
Last modified:March 3, 2009 - v1
Checksum:i66B10865BACE56A6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NZW5MPP6_HUMAN
MAGUK p55 subfamily member 6
MPP6 VAM1
540Annotation score:
C9JGI8C9JGI8_HUMAN
MAGUK p55 subfamily member 6
MPP6
217Annotation score:
C9J4Q3C9J4Q3_HUMAN
MAGUK p55 subfamily member 6
MPP6
307Annotation score:
F8WCD2F8WCD2_HUMAN
MAGUK p55 subfamily member 6
MPP6
41Annotation score:
R4GNA8R4GNA8_HUMAN
MAGUK p55 subfamily member 6
MPP6
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003093 Genomic DNA No translation available.
AC005084 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93808.1
RefSeqiXP_005249832.1, XM_005249775.4
UniGeneiHs.533355
Hs.563501
Hs.594275

Genome annotation databases

EnsembliENST00000409761; ENSP00000386262; ENSG00000105926
GeneIDi51678
UCSCiuc064ccd.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003093 Genomic DNA No translation available.
AC005084 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93808.1
RefSeqiXP_005249832.1, XM_005249775.4
UniGeneiHs.533355
Hs.563501
Hs.594275

3D structure databases

SMRiB8ZZG1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB8ZZG1
MaxQBiB8ZZG1
PRIDEiB8ZZG1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409761; ENSP00000386262; ENSG00000105926
GeneIDi51678
UCSCiuc064ccd.1 human

Organism-specific databases

CTDi51678
EuPathDBiHostDB:ENSG00000105926.15
HGNCiHGNC:18167 MPP6
OpenTargetsiENSG00000105926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858

Miscellaneous databases

ChiTaRSiMPP6 human
GenomeRNAii51678

Gene expression databases

BgeeiENSG00000105926 Expressed in 136 organ(s), highest expression level in testis

Family and domain databases

CDDicd12038 SH3_MPP6, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR035603 MPP6_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB8ZZG1_HUMAN
AccessioniPrimary (citable) accession number: B8ZZG1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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