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Protein
Submitted name:

Large T antigen

Gene

LT-Ag

Organism
Merkel cell polyomavirus
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi316 – 430T-ag OBDPROSITE-ProRule annotationAdd BLAST115

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation, HydrolaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Large T antigenImported
Gene namesi
Name:LT-AgImported
OrganismiMerkel cell polyomavirusImported
Taxonomic identifieri493803 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridae

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 430T-ag OBDInterPro annotationAdd BLAST115
Domaini437 – 528T-ag D1-typeInterPro annotationAdd BLAST92
Domaini567 – 727SF3 helicaseInterPro annotationAdd BLAST161

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR014015 Helicase_SF3_DNA-vir
IPR036869 J_dom_sf
IPR010932 Lg_T_Ag_Polyomavir_C
IPR027417 P-loop_NTPase
IPR003133 T_Ag_DNA-bd
IPR017910 Znf_lg_T-Ag_D1-typ
PfamiView protein in Pfam
PF06431 Polyoma_lg_T_C, 1 hit
PF02217 T_Ag_DNA_bind, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51206 SF3_HELICASE_1, 1 hit
PS51287 T_AG_OBD, 1 hit
PS51341 ZF_LTAG_D1, 1 hit

Sequencei

Sequence statusi: Complete.

B8ZX42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLVLNRKER EALCKLLEIA PNCYGNIPLM KAAFKRSCLK HHPDKGGNPV
60 70 80 90 100
IMMELNTLWS KFQQNIHKLR SDFSMFDEVD EAPIYGTTKF KEWWRSGGFS
110 120 130 140 150
FGKAYEYGPN PHGTNSRSRK PSSNASRGAP SGSSPPHSQS SSSGYGSFSA
160 170 180 190 200
SQASDSQSRG PDIPPEHHEE PTSSSGSSSR EETTNSGRES STPNGTSVPR
210 220 230 240 250
NSSRTDGTWE DLFCDESLSS PEPPSSSEEP EEPPSSRSSP RQPPSSSAEE
260 270 280 290 300
ASSSQFTDEE YRSSSFTTPK TPPPFSRKRK FGGSRSSASS ASSASFTSTP
310 320 330 340 350
PKPKKNRETP VPTDFPIDLS DYLSHAVYSN KTVSCFAIYT TSDKAIELYD
360 370 380 390 400
KIEKFKVDFK SRHACELGCI LLFITLSKHR VSAIKNFCST FCTISFLICK
410 420 430 440 450
GVNKMPEMYN NLCKPPYKLL QEDKPLLNYE FQEKEKEASC NWNLVAEFAC
460 470 480 490 500
EYELDDHFII LAHYLDFAKP FPCQKCENRS RLKPHKAHEA HHSNAKLFYE
510 520 530 540 550
SKSQKTICQQ AADTVLAKRR LEMLEMTRTE TLCKKFKKHL ERLRDLDTID
560 570 580 590 600
LLYYMGGVAW YCCLFEEFEK KLQKIIQLLT ENIPKYRNIW FKGPINSGKT
610 620 630 640 650
SFAAALIDLL EGKALNINCP SDKLPFELGC ALDKFMVVFE DVKGQNSLNK
660 670 680 690 700
DLQPGQGINN LDNLRDHLDG AVAVSLEKKH ANKKHQIFPP CIVTANDYFI
710 720 730 740 750
PKTLIARFSY TLHFSPKANL RDSLDQNMEI RKRRILQSGT TLLLCLIWCL
760 770 780 790 800
PDTTFKPCLQ EEIKNWKQIL QSEISYGKFC QMIENVEAGQ DPLLNILIEE
810
EGPEETEETQ DSGTFSQ
Length:817
Mass (Da):92,281
Last modified:March 3, 2009 - v1
Checksum:i0CBF20070C0C2EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM955586 Genomic DNA Translation: CAW30976.1
FM955592 Genomic DNA Translation: CAW30988.1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM955586 Genomic DNA Translation: CAW30976.1
FM955592 Genomic DNA Translation: CAW30988.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR014015 Helicase_SF3_DNA-vir
IPR036869 J_dom_sf
IPR010932 Lg_T_Ag_Polyomavir_C
IPR027417 P-loop_NTPase
IPR003133 T_Ag_DNA-bd
IPR017910 Znf_lg_T-Ag_D1-typ
PfamiView protein in Pfam
PF06431 Polyoma_lg_T_C, 1 hit
PF02217 T_Ag_DNA_bind, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51206 SF3_HELICASE_1, 1 hit
PS51287 T_AG_OBD, 1 hit
PS51341 ZF_LTAG_D1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB8ZX42_9POLY
AccessioniPrimary (citable) accession number: B8ZX42
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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