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Entry version 49 (11 Dec 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Large T antigen

Gene

LT-Ag

Organism
Merkel cell polyomavirus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi316 – 430T-ag OBDPROSITE-ProRule annotationAdd BLAST115

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation, HydrolaseSAAS annotation
Biological processDNA replicationSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Large T antigenImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LT-AgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMerkel cell polyomavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri493803 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesPolyomaviridaeAlphapolyomavirus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 430T-ag OBDInterPro annotationAdd BLAST115
Domaini437 – 528T-ag D1-typeInterPro annotationAdd BLAST92
Domaini567 – 727SF3 helicaseInterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 311DisorderedSequence analysisAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 159PolarSequence analysisAdd BLAST49
Compositional biasi161 – 175PolyampholyteSequence analysisAdd BLAST15
Compositional biasi176 – 208PolarSequence analysisAdd BLAST33
Compositional biasi226 – 240Pro-richSequence analysisAdd BLAST15
Compositional biasi241 – 272PolarSequence analysisAdd BLAST32
Compositional biasi282 – 304PolarSequence analysisAdd BLAST23

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014015 Helicase_SF3_DNA-vir
IPR036869 J_dom_sf
IPR010932 Lg_T_Ag_Polyomavir_C
IPR027417 P-loop_NTPase
IPR003133 T_Ag_DNA-bd
IPR017910 Znf_lg_T-Ag_D1-typ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06431 Polyoma_lg_T_C, 1 hit
PF02217 T_Ag_DNA_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51206 SF3_HELICASE_1, 1 hit
PS51287 T_AG_OBD, 1 hit
PS51341 ZF_LTAG_D1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8ZX42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLVLNRKER EALCKLLEIA PNCYGNIPLM KAAFKRSCLK HHPDKGGNPV
60 70 80 90 100
IMMELNTLWS KFQQNIHKLR SDFSMFDEVD EAPIYGTTKF KEWWRSGGFS
110 120 130 140 150
FGKAYEYGPN PHGTNSRSRK PSSNASRGAP SGSSPPHSQS SSSGYGSFSA
160 170 180 190 200
SQASDSQSRG PDIPPEHHEE PTSSSGSSSR EETTNSGRES STPNGTSVPR
210 220 230 240 250
NSSRTDGTWE DLFCDESLSS PEPPSSSEEP EEPPSSRSSP RQPPSSSAEE
260 270 280 290 300
ASSSQFTDEE YRSSSFTTPK TPPPFSRKRK FGGSRSSASS ASSASFTSTP
310 320 330 340 350
PKPKKNRETP VPTDFPIDLS DYLSHAVYSN KTVSCFAIYT TSDKAIELYD
360 370 380 390 400
KIEKFKVDFK SRHACELGCI LLFITLSKHR VSAIKNFCST FCTISFLICK
410 420 430 440 450
GVNKMPEMYN NLCKPPYKLL QEDKPLLNYE FQEKEKEASC NWNLVAEFAC
460 470 480 490 500
EYELDDHFII LAHYLDFAKP FPCQKCENRS RLKPHKAHEA HHSNAKLFYE
510 520 530 540 550
SKSQKTICQQ AADTVLAKRR LEMLEMTRTE TLCKKFKKHL ERLRDLDTID
560 570 580 590 600
LLYYMGGVAW YCCLFEEFEK KLQKIIQLLT ENIPKYRNIW FKGPINSGKT
610 620 630 640 650
SFAAALIDLL EGKALNINCP SDKLPFELGC ALDKFMVVFE DVKGQNSLNK
660 670 680 690 700
DLQPGQGINN LDNLRDHLDG AVAVSLEKKH ANKKHQIFPP CIVTANDYFI
710 720 730 740 750
PKTLIARFSY TLHFSPKANL RDSLDQNMEI RKRRILQSGT TLLLCLIWCL
760 770 780 790 800
PDTTFKPCLQ EEIKNWKQIL QSEISYGKFC QMIENVEAGQ DPLLNILIEE
810
EGPEETEETQ DSGTFSQ
Length:817
Mass (Da):92,281
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CBF20070C0C2EF9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FM955586 Genomic DNA Translation: CAW30976.1
FM955592 Genomic DNA Translation: CAW30988.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM955586 Genomic DNA Translation: CAW30976.1
FM955592 Genomic DNA Translation: CAW30988.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR014015 Helicase_SF3_DNA-vir
IPR036869 J_dom_sf
IPR010932 Lg_T_Ag_Polyomavir_C
IPR027417 P-loop_NTPase
IPR003133 T_Ag_DNA-bd
IPR017910 Znf_lg_T-Ag_D1-typ
PfamiView protein in Pfam
PF06431 Polyoma_lg_T_C, 1 hit
PF02217 T_Ag_DNA_bind, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51206 SF3_HELICASE_1, 1 hit
PS51287 T_AG_OBD, 1 hit
PS51341 ZF_LTAG_D1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8ZX42_9POLY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8ZX42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 11, 2019
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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