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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayi
UPA00098;UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:MLBr01458
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006900 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001936271 – 409Gamma-glutamyl phosphate reductaseAdd BLAST409

Structurei

3D structure databases

ProteinModelPortaliB8ZRN0
SMRiB8ZRN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

KOiK00147
OMAiHGSHHTD
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

B8ZRN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQEVHDAAR RARVAARALA VMPTVAKDHA LRAAATAVTA HTEEILAANA
60 70 80 90 100
EDLQAARATD TLAATLDRLA LDRQRIDQIA GGLRQVAALP DPIGEVLRGY
110 120 130 140 150
TLPNGLQLRQ QRVPLGVVGM IYEGRPNITV DAFGLAFKSG NAALLRGSSS
160 170 180 190 200
AAKSNQALVE VLHAALVSED LPADAVQLLS AADRSTVTHL IQARGLVDVV
210 220 230 240 250
IPRGGANLID AVVRDAQVPI IETGVGNCHV YVHQAADLEV AERILLNSKT
260 270 280 290 300
RRPSVCNAAE TLLIDAAIAD HTMPRLVAAL QGAGVTVHGG LSGDPDKADL
310 320 330 340 350
CREYLSMDIA VAVVDGVDAA IAHINEYGTG HTEAIVTTNM AAAQRFADGV
360 370 380 390 400
DSATVMVNAS TAFTDGGQFG FGAEIGISTQ KLHARGPMGL SEMTSTKWIV

WGDGQIRPA
Length:409
Mass (Da):42,813
Last modified:March 3, 2009 - v1
Checksum:iFFD60877C416DC77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA Translation: CAR71552.1
RefSeqiWP_010908348.1, NC_011896.1

Genome annotation databases

EnsemblBacteriaiCAR71552; CAR71552; MLBr01458
KEGGimlb:MLBr01458

Similar proteinsi

Entry informationi

Entry nameiPROA_MYCLB
AccessioniPrimary (citable) accession number: B8ZRN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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