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Entry version 74 (31 Jul 2019)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

JNK-interacting leucine zipper protein long form

Gene

Spag9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
JNK-interacting leucine zipper protein long formImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spag9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918084 Spag9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
B8X349

PeptideAtlas

More...
PeptideAtlasi
B8X349

PRoteomics IDEntifications database

More...
PRIDEi
B8X349

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B8X349 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 95RH1InterPro annotationAdd BLAST89
Domaini486 – 590RH2InterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni208 – 294DisorderedSequence analysisAdd BLAST87
Regioni308 – 327DisorderedSequence analysisAdd BLAST20
Regioni459 – 486DisorderedSequence analysisAdd BLAST28
Regioni549 – 586DisorderedSequence analysisAdd BLAST38
Regioni839 – 869DisorderedSequence analysisAdd BLAST31
Regioni1238 – 1266DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili75 – 102Sequence analysisAdd BLAST28
Coiled coili107 – 162Sequence analysisAdd BLAST56
Coiled coili494 – 514Sequence analysisAdd BLAST21
Coiled coili713 – 740Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi222 – 241PolarSequence analysisAdd BLAST20
Compositional biasi249 – 275PolarSequence analysisAdd BLAST27
Compositional biasi565 – 586PolarSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077 Eukaryota
ENOG410XQ19 LUCA

Database of Orthologous Groups

More...
OrthoDBi
324912at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886 PTHR13886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8X349-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELEDGVVYQ EEPGGSGAVM SERVSGLAGS IYREFERLIG RYDEEVVKEL
60 70 80 90 100
MPLVVAVLEN LDSVFAQDQE HQVELELLRD DNEQLITQYE REKALRKHAE
110 120 130 140 150
EKFIEFEDSQ EQEKKDLQTR VESLESQTRQ LELKAKNYAD QISRLEEREA
160 170 180 190 200
ELKKEYNALH QRHTEMIHNY MEHLERTKLH QLSGSDQLEA TAHSRIRKER
210 220 230 240 250
PISLGIFPLP AGDGLLTPDT QKGGETPGSE QWKFQELSQP RSHTSLKDEL
260 270 280 290 300
SDISQGGSKA TTPASTANSD VSAIPPDTPS KEDNEGFVKG TDTSNKSEIS
310 320 330 340 350
KHIEVQVAQE TRNVSTESGE NEEKSEVQAI IESTPELDMD KDLSGYKGSS
360 370 380 390 400
TPTKGIENKA FDRNTESLFE ELSSAGSGLI GDVDEGADLL GMGREVENLI
410 420 430 440 450
LENTQLLETK NALNVVKNDL IAKVDELTCE KDVLQGELEA VKQAKLKLED
460 470 480 490 500
KNRELEEELR KARAEAEDAR QKAKDDDDSD IPTAQRKRFT RVEMARVLME
510 520 530 540 550
RNQYKERLME LQEAVRWTEM IRASRENPAM QEKKRSSIWQ FFSRLFSSSS
560 570 580 590 600
NATKKPEPPV NLKYNAPTSH VTPSVKKRSS TLSQLPGDKS KAFDFLSEET
610 620 630 640 650
EASLASRREQ KREQYRQVKA HVQKEDGRVQ AFGWSLPQKY KQVANGQGET
660 670 680 690 700
KMKNLPVPVY LRPLDEKDAS MKLWCAVGVN LSGGKTRDGG SVVGASVFYK
710 720 730 740 750
DIAGLDTEGS KQRSASQSSL DKLDQELKEQ QKEFKNQEEL SSQVWICTST
760 770 780 790 800
HSTTKVIIID AVQPGNILDS FTVCNSHVLC IASVPGARET DYPAGEELSE
810 820 830 840 850
SGQVDKASLC GSMTSNSSAE MDSLLGGITV VGCSTEGLTG AATSPSTNGA
860 870 880 890 900
SPVIEKPPEM ETENSEVDEN IPTAEEATEA TEGNAGSTED TVDISQPGVY
910 920 930 940 950
TEHVFTDPLG VQIPEDLSPV FQSSNDSDVY KDQISVLPNE QDLAREEAQK
960 970 980 990 1000
MSSLLPTMWL GAQNGCLYVH SSVAQWRKCL HSIKLKDSIL SIVHVKGIVL
1010 1020 1030 1040 1050
VALADGTLAI FHRGVDGQWD LSNYHLLDLG RPHHSIRCMT VVHDKVWCGY
1060 1070 1080 1090 1100
RNKIYVVQPK AMKIEKSFDA HPRKESQVRQ LAWVGDGVWV SIRLDSTLRL
1110 1120 1130 1140 1150
YHAHTYQHLQ DVDIEPYVSK MLGTGKLGFS FVRITALMVS CNRLWVGTGN
1160 1170 1180 1190 1200
GVIISIPLTE TVILHQGRLL GLRANKTSGT PGNRPGSVIR VYGDENSDKV
1210 1220 1230 1240 1250
TPGTFIPYCS MAHAQLCFHG HRDAVKFFVA VPGQVISPQS SSGGADLTAD
1260 1270 1280 1290 1300
KAGSSAQEPS SQTPLKSMLV ISGGEGYIDF RMGDEGGESE LLGEDLPLEP
1310 1320
SVTKAERSHL IVWQVMCGNE
Length:1,320
Mass (Da):146,131
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FBEC413AAF74DF2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FJ042496 mRNA Translation: ACL13004.1

NCBI Reference Sequences

More...
RefSeqi
NP_001186133.1, NM_001199204.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
70834

UCSC genome browser

More...
UCSCi
uc011ycs.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ042496 mRNA Translation: ACL13004.1
RefSeqiNP_001186133.1, NM_001199204.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiB8X349
PeptideAtlasiB8X349
PRIDEiB8X349

Genome annotation databases

GeneIDi70834
UCSCiuc011ycs.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9043
MGIiMGI:1918084 Spag9

Phylogenomic databases

eggNOGiKOG2077 Eukaryota
ENOG410XQ19 LUCA
OrthoDBi324912at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spag9 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiB8X349 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13886 PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8X349_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8X349
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 31, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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