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Entry version 12 (07 Nov 2018)
Sequence version 1 (09 Jul 2014)
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Protein

Protocadherin-like protein

Gene
N/A
Organism
Acropora millepora (Staghorn coral)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcropora millepora (Staghorn coral)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45264 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaAstrocoeniinaAcroporidaeAcropora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 4258ExtracellularSequence analysisAdd BLAST4236
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4259 – 4279HelicalSequence analysisAdd BLAST21
Topological domaini4280 – 4467CytoplasmicSequence analysisAdd BLAST188

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042955223 – 4467Protocadherin-like proteinSequence analysisAdd BLAST4445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3555 ↔ 3567Sequence analysis
Disulfide bondi3561 ↔ 3577Sequence analysis
Disulfide bondi3579 ↔ 3588Sequence analysis
Disulfide bondi3762 ↔ 3788Sequence analysis
Disulfide bondi3794 ↔ 3803Sequence analysis
Disulfide bondi3797 ↔ 3812Sequence analysis
Disulfide bondi3814 ↔ 3823Sequence analysis
Disulfide bondi4207 ↔ 4218Sequence analysis
Disulfide bondi4212 ↔ 4226Sequence analysis
Disulfide bondi4228 ↔ 4237Sequence analysis

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Component of the acid-insoluble organic matrix of the aragonitic skeleton (at protein level).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B8V7Q1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 128Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini129 – 238Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini239 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini459 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST108
Domaini567 – 664Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Domaini665 – 764Cadherin 7PROSITE-ProRule annotationAdd BLAST100
Domaini765 – 884Cadherin 8PROSITE-ProRule annotationAdd BLAST120
Domaini885 – 994Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1092 – 1197Cadherin 10PROSITE-ProRule annotationAdd BLAST106
Domaini1290 – 1395Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1396 – 1499Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1495 – 1597Cadherin 13PROSITE-ProRule annotationAdd BLAST103
Domaini1601 – 1701Cadherin 14PROSITE-ProRule annotationAdd BLAST101
Domaini1793 – 1891Cadherin 15PROSITE-ProRule annotationAdd BLAST99
Domaini1892 – 1992Cadherin 16PROSITE-ProRule annotationAdd BLAST101
Domaini1993 – 2100Cadherin 17PROSITE-ProRule annotationAdd BLAST108
Domaini2101 – 2202Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2203 – 2312Cadherin 19PROSITE-ProRule annotationAdd BLAST110
Domaini2313 – 2423Cadherin 20PROSITE-ProRule annotationAdd BLAST111
Domaini2425 – 2529Cadherin 21PROSITE-ProRule annotationAdd BLAST105
Domaini2530 – 2639Cadherin 22PROSITE-ProRule annotationAdd BLAST110
Domaini2640 – 2746Cadherin 23PROSITE-ProRule annotationAdd BLAST107
Domaini2747 – 2849Cadherin 24PROSITE-ProRule annotationAdd BLAST103
Domaini2850 – 2954Cadherin 25PROSITE-ProRule annotationAdd BLAST105
Domaini2955 – 3062Cadherin 26PROSITE-ProRule annotationAdd BLAST108
Domaini3063 – 3170Cadherin 27PROSITE-ProRule annotationAdd BLAST108
Domaini3173 – 3288Cadherin 28PROSITE-ProRule annotationAdd BLAST116
Domaini3551 – 3589EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini3590 – 3788Laminin G-like 1PROSITE-ProRule annotationAdd BLAST199
Domaini3790 – 3824EGF-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini3842 – 4096Laminin G-like 2PROSITE-ProRule annotationAdd BLAST255
Domaini4206 – 4238EGF-like 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 23 hits
PF01049 Cadherin_C, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 31 hits
SM00181 EGF, 2 hits
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 30 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 9 hits
PS50268 CADHERIN_2, 31 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

B8V7Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGINAIVGF LLCFCLLHRI NTAVQFKQEI LEEGKSAGYV VLSLPLPPSN
60 70 80 90 100
EIYTFFQAQD SGSRDALLLF QISESGVIKT TKPITYEIGQ KNYYDLVAIR
110 120 130 140 150
RQRGEKVGGI PTSIRIVIKD TNNFSPTFPQ HLYYGRVKER SPDNTVVMGL
160 170 180 190 200
ENCFAEDRDT GGIQSYSISS GNDKGYFKTS MTTVNDRKFL VLKTTNVPIL
210 220 230 240 250
IDTTPEINLT VRAYDGANSA TTGITVKIID ENDNSPVFEK KSYATTVNED
260 270 280 290 300
TPLLTSVLRV RATDKDLGTN GGVYYYLNGA QYFSVDAITG VIKVVRQLPD
310 320 330 340 350
QPRIVLDVKA TDRGTPSKTA SVQVTIDING IPDYPPPDSS NPGVNTVPVF
360 370 380 390 400
QEESYTASVR EDFPINAALL VIHAIDRDPP GRNRQIRYSL SSSGTFEIDQ
410 420 430 440 450
FSGVVKLVGR LNYDSKKQYN LFVRATDQAL TPLVASASLK VTVQEVDKNR
460 470 480 490 500
NTPVFSPANP QQRMVSIKEN MPASTQVGSL ITATDADGNQ GPDGQIAYSI
510 520 530 540 550
FSGSGLPYFQ INKDTGRLET VIRLDRERQS QYDLIVEARD KALYPLFSHV
560 570 580 590 600
YLMINIDPEE DNNPDFSKVV YTANVPEKAP RDTFVTVIHA TDRDGASVSY
610 620 630 640 650
SIQNAGSAFA IRAETGVIVT ARVLDASIGD TDFTLFVTAS AGTKKSESQI
660 670 680 690 700
NVTIVSKQDS PPTFKNAPYS VTVPENLGKI DNLLCIAAYG VRGTAVSYSI
710 720 730 740 750
ASAAVGKFAV DIDSGRFSAT SSFDYEQVLG GEYPVQVQAS TSPQQVATAG
760 770 780 790 800
ITVRVTDDKD PPTFSRSSYT FDIDENTPGG TTILPKNADG SSGGLLISDE
810 820 830 840 850
DTAITQFDCT IENVPGNVFD HFRVVNPDNS VRECKLVTVR GFNFVENPSF
860 870 880 890 900
QFEVRATDRN YRNMFASAQV KVVIKDTNNH SPEFSQTSYW ASVGRDYPTG
910 920 930 940 950
NSILKVTATD QDSGSFGEIT YELLNTQDRS RFSLDSNTGV LSFPNSLPAR
960 970 980 990 1000
RYQLRVQASD RAQKSNEIRR TEVDVFVTVY LPGTGIIVFD PPLFPKAIRE
1010 1020 1030 1040 1050
DITINTQVKL VSTRGASNIK YSIVGGNTNN AFRIGSNNGQ ILVQKALDRE
1060 1070 1080 1090 1100
TQSKYTLVIR AEESTSNVAT EANFIISVTD VNDNPPRITF MEAQPKNIAI
1110 1120 1130 1140 1150
EDFSPPGSPV IRVIATDPDT GAAAAIKYSI TIGTPFSINE DNGLITAARE
1160 1170 1180 1190 1200
IRKTERSTWD LTVTARDSGT PSRNSAPYRL RIHVTDGLQA PQLQPRFSVN
1210 1220 1230 1240 1250
VNENEQVGNV VKDISPVQKN PNFKYSILSG NRDDAFCINH AGMISVAKPL
1260 1270 1280 1290 1300
DREKVNSYIL RVSASVGNKI SNSTVSVTIA DQNDDAPQFS RTVYTFEVRE
1310 1320 1330 1340 1350
DLPQGREVGR VFAIDRDDGT NGQVSYSLLY TVDVNSKFTV DGATGAVVTG
1360 1370 1380 1390 1400
SVLDFEEIRQ HILYVKAEDK GRPLRTSIAK VIVNVKDVND RSPKFSADSY
1410 1420 1430 1440 1450
VTKVSLDEVI GTQVLLVSAT DLDSGDNSVV VYNITAGNEE GAFEIDPDTG
1460 1470 1480 1490 1500
AIKVKKSLTT VSASKFSLRV EAKDKGNPPR MTPTTVQLNI FLPDGPPKFV
1510 1520 1530 1540 1550
VKPVVEERFE GIAANGRVMV VKAATSEALT YEIISGNEDG LFRIEPTTGE
1560 1570 1580 1590 1600
IKVTRVLDYE EASEHRLVVR VMDTRDRSDR VTVILKVKNI NDNEPQFPGE
1610 1620 1630 1640 1650
SNGFVERKVE DDFQIGDAAA RLSAYDKDAG DSISYQLSAN ALPLFSIDNE
1660 1670 1680 1690 1700
GFLIAKKPRS EIQSPVKFEL VAKDNGVPQR QTTVQVRLVF VSYRGDQQPV
1710 1720 1730 1740 1750
RVYVREDKEV GSVIARVPRF FPGGTLSIIF PQKANFTVDN SGRIRMTTAF
1760 1770 1780 1790 1800
DFEQSQFYRL TVREQEPAPG RRTNDIDVEI NVVDVNDNKP KFTMIDFFGR
1810 1820 1830 1840 1850
VNTNSRPGTS AYQLKAEDKD GGLSGTVGYQ MLSRDVPFGI NPISGVVETD
1860 1870 1880 1890 1900
ATLQDRGGYN ITVFPFDFGV PREFGAAVSL DIKTVNFKPQ FSESAYRFQV
1910 1920 1930 1940 1950
FENAPPGVIV GEVNATSLSG ARLGFSVPLG DPSKKFEVHN SGEIRLNSRL
1960 1970 1980 1990 2000
DHEKQSIYNL KVRATELIPG GYSNEVEVQV TVTNANEYYP KFEPNLYFKV
2010 2020 2030 2040 2050
VNENVAAGQS VLRVTAIDKD CGTTSKCEAG LLKFSVEGTS LFKIDPRTGD
2060 2070 2080 2090 2100
VSVGSTPLDY EKQREHVFTV VVEDFGEKIY KSRGFVTIDV RNTDDEKPQF
2110 2120 2130 2140 2150
LESDYTISIA EDAETGRPLA AILARDADGD PVKYSITSGD SGGIFQINPT
2160 2170 2180 2190 2200
TGVLSLKSSI KGNPRTQYTL QVKASNSAQD SRFDEVRVVV NIEDSNDNRP
2210 2220 2230 2240 2250
VFTDCPPEVP VEENKPRGHR VYQVVAQDTK DRGRNKEIEY FLVTGGERLF
2260 2270 2280 2290 2300
EIDNTTGVIK TLTSLDRETK DQHTLIIMAE DGGHGRNSAE RLLSYCILDV
2310 2320 2330 2340 2350
KVVDQNDNFP FFLTRTYYAS VWQGAPVNTE VLTVRAADMD TRVNANIDNS
2360 2370 2380 2390 2400
EVQYQLVNAD DKFQVELATG VIKTKATLVS FVGKVQLQIR AINKQPMAIS
2410 2420 2430 2440 2450
EERPRTSTTT VEINVEKDKP PAFAPSAVYK SAINEDVKIG KEVQQILAIS
2460 2470 2480 2490 2500
QVDRKNKIVY SFVKSNPEGE QKFQIDPATG NITTASTLDY EQVKEYRLQF
2510 2520 2530 2540 2550
RATDIATNLY ATCVVIISLI DVNDDTPTFK LEEYTARVPE NAAVDFNVIT
2560 2570 2580 2590 2600
IEADDRDTAL SGQVGYTLEV SDSSEGQFFA INGQTGVMIT KKSFDREDPK
2610 2620 2630 2640 2650
HIPKYNVFAV ATDKGVPPLA AKVTISVAIV DQNDQPPIFP KPSYEVSVQE
2660 2670 2680 2690 2700
DAGIGTSVGE FTATDADIGD NARLDYFISS GDASHIFKME SVYGDNNFGI
2710 2720 2730 2740 2750
LILAGKLDFE TKKTYNISIT ATDRKDSATV PVVVNVLDTN DNIPKFDNLI
2760 2770 2780 2790 2800
YEAIIPENSP PGQRVETVSA TDLDSPKIQN DLRYSLDADG QKNFAVDAVS
2810 2820 2830 2840 2850
GLITTANQRL DREVNPVVTF TAFAFDGKHR GEALIRVTLR DVNDNSPYFP
2860 2870 2880 2890 2900
NPPYVGYVEE NLDPGASVMV IQAFDLDSGI DGEIVYSLDD SSNNKFKIDR
2910 2920 2930 2940 2950
ISGLVTTVET MEKETAVNSF TIVVKATDKG SPALSGTVTA TIRVSDGNDQ
2960 2970 2980 2990 3000
APVFNPREYR QKVPEDSPPG FLVTQVKATD QDEGYNAELE FTITAGNDPY
3010 3020 3030 3040 3050
QFYIDPKTGE ILVSGMLDFD HGKKSYNLTV MVSDRGVPPK QAAKPAFVYI
3060 3070 3080 3090 3100
TIVDSNDNPP VFVPAEYSIK VTEGTKPGDT VQLVTAVDQD TGTNALFTFG
3110 3120 3130 3140 3150
IADGDDADMF GIRPDPKNSS IGFIYTVLQL DRETVPQYNL TVTATDTGGL
3160 3170 3180 3190 3200
QGVAVVRITV LDTNDNGPWF QPRYYEGSIT VTSDSNSQQE ITTVKVFDPD
3210 3220 3230 3240 3250
EPSNGPPFSF SIESTKPATD ATRFGLRKDP KEPQTANEVY SIGAFTRQVP
3260 3270 3280 3290 3300
EWELTIKAID SGKPVAMFNS TLVFVWVVDD KNLNEPFDGA LTIIVNAYDD
3310 3320 3330 3340 3350
KFAGGIIGKA YYQDVDYMGD ENTYSMSEQE YFTLGELTGD ISAAANIPVG
3360 3370 3380 3390 3400
LYKFEIEVLE QRLRPNTNTF KTVTSSVSVI VQSVPRAAIL QSVAVQILAY
3410 3420 3430 3440 3450
RRPALFVADI YTNFRQKLAG IFGVQEADIL IFSVQRAPSK RVPLADVFGV
3460 3470 3480 3490 3500
EIQLAVRSSG SSFMDKMDVV RGIVEGKAEL EALSLKIGDI GIDVCAAERQ
3510 3520 3530 3540 3550
DVGVCNNKVE ASSAFTVVSG DIGQIEPSKS SLTVVSIDIT LKAVYTSILP
3560 3570 3580 3590 3600
PDINCTTGTP CLHGGTCHNA VPKGIICECG RDYLGPECQS TTRTFRGNSY
3610 3620 3630 3640 3650
LWLDKLASYE RSSISLQFMT GSANGLLLYQ GPLYNGANNG LPDSIALYLV
3660 3670 3680 3690 3700
DGFAKLVIAL GPHPMTPLEL YMNKGDRLDD RTWHTVQVIR ERKKVVLRID
3710 3720 3730 3740 3750
KCSYSKIVED YGQIVEDRSS CEIKGEIWGS AIYLNGFGPL QIGGVENSIS
3760 3770 3780 3790 3800
DMKINFTGFS GCIRNIYNNG RMYDLFNPLK EVNTELGCRL NNQCPNCNGR
3810 3820 3830 3840 3850
GYCEPFWNYA ICVCDLGFGG ANCDSRTQAN WYRANSFTQY RVKQVKRKRR
3860 3870 3880 3890 3900
ELVPAPVSMA NEFYTNIALQ VRVSPNSSNV VIFLASNSLG TEFNRIDVKN
3910 3920 3930 3940 3950
HVLRYAFRLG DRMKILKIPQ LNVTDDKYHT VIVKREGNRA SLQIDYRGKV
3960 3970 3980 3990 4000
EGTTGGLHKL LNMGGGSFFT GGLPNITEVR VVEAFVNSGG NAVLRTAEGN
4010 4020 4030 4040 4050
IISSGMGSAY TGIGSYMSNV ITVNNFGGVD VSYGVSGAPH VQRTIKTKSS
4060 4070 4080 4090 4100
IFTGSSGVIT RISVSRGHSV EFMNSRFFTR KTKQKQKVII SSSGGSVSGG
4110 4120 4130 4140 4150
SGGASGGSGG ASGSGGSVGV SGGGGASVGG SILGSSASMD TKGNLRSYGS
4160 4170 4180 4190 4200
GFGTWTIAGA GPNEAGDVQV IGDFGGCTAS NSYNGLDLDS HPTIEARRQN
4210 4220 4230 4240 4250
VEFPCPCGSN FCRHGGTCVS ADPPYCLCPV GWSGPVCESI VKDPRPGQRP
4260 4270 4280 4290 4300
SSRWANPAVI ACILVILLAI LVIIGAVLLK RRPQPAVVAV VEDGHVHDNV
4310 4320 4330 4340 4350
RPYHDEGAGE EDNFGYDIST LMKYTYVENG VAGTGGVGHG KFKNGGSSGE
4360 4370 4380 4390 4400
EEFTATETKP LLQGAMPDDD LHFKTTTITK RKVVHPDSID VKQFIDTRAS
4410 4420 4430 4440 4450
EADGEYILSI DELHIYRYEG DDSDVDDLSE LGDSDEEPDE EEEQEFAFLQ
4460
DWGKKFDNLN RIFNEDE
Length:4,467
Mass (Da):488,589
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i424AB248C66E6C08
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JT011093 mRNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JT011093 mRNA No translation available.

3D structure databases

SMRiB8V7Q1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR013320 ConA-like_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 23 hits
PF01049 Cadherin_C, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 31 hits
SM00181 EGF, 2 hits
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 30 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 9 hits
PS50268 CADHERIN_2, 31 hits
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDL_ACRMI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8V7Q1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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