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Protein

Hadrucalcin

Gene
N/A
Organism
Hadrurus gertschi (Scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates both skeletal ryanodine receptors (RYR1) and cardiac ryanodine receptors (RYR2) by inducing a long-lasting subconductance state, rapidly permeating the external membrane of cardiomyocytes and inducing calcium release from intracellular stores. Acts synergistically with caffeine.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Ryanodine-sensitive calcium-release channel impairing toxin, Toxin

Protein family/group databases

TCDBi8.B.16.1.3 the maurocalcine family

Names & Taxonomyi

Protein namesi
Recommended name:
HadrucalcinImported
Short name:
HdCa1 Publication
OrganismiHadrurus gertschi (Scorpion)
Taxonomic identifieri380989 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaIuroideaHadrurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000038367128 – 39Sequence analysis1 PublicationAdd BLAST12
PeptideiPRO_500043351240 – 74Hadrucalcin1 PublicationAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi51 ↔ 62By similarity
Disulfide bondi57 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliB8QG00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the scorpion calcine family.Sequence analysis

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR012632 Scorpion_calcine
PfamiView protein in Pfam
PF08099 Toxin_27, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD874489 Scorpion_calcine, 1 hit
PROSITEiView protein in PROSITE
PS60028 SCORPION_CALCINE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8QG00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTSSLTIIF IAVIITIICL NIHDIEAREI EFNAGRVVRS EKDCIKHLQR
60 70
CRENKDCCSK KCSRRGTNPE KRCR
Length:74
Mass (Da):8,593
Last modified:March 3, 2009 - v1
Checksum:i12D5F2B54C1640A2
GO

Mass spectrometryi

Molecular mass is 4190.5 Da from positions 40 - 74. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU496812 mRNA Translation: ACC99422.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU496812 mRNA Translation: ACC99422.1

3D structure databases

ProteinModelPortaliB8QG00
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.16.1.3 the maurocalcine family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012632 Scorpion_calcine
PfamiView protein in Pfam
PF08099 Toxin_27, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD874489 Scorpion_calcine, 1 hit
PROSITEiView protein in PROSITE
PS60028 SCORPION_CALCINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCXC_HADGE
AccessioniPrimary (citable) accession number: B8QG00
Secondary accession number(s): P85499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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