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Entry version 53 (16 Jan 2019)
Sequence version 1 (03 Mar 2009)
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Protein

DNA-directed RNA polymerase subunit

Gene

AFLA_033270

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AFLA_033270Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri332952 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001875 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:AFLA_033270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B8N404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5059.CADAFLAP00002702

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 550RPOLA_NInterPro annotationAdd BLAST307

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000222975

KEGG Orthology (KO)

More...
KOi
K03006

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDGLCGE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
3.30.1360.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722 RNA_pol_asu
IPR000684 RNA_pol_II_repeat_euk
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR007075 RNA_pol_Rpb1_6
IPR007073 RNA_pol_Rpb1_7
IPR038593 RNA_pol_Rpb1_7_sf
IPR038120 Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
PF04992 RNA_pol_Rpb1_6, 1 hit
PF04990 RNA_pol_Rpb1_7, 1 hit
PF05001 RNA_pol_Rpb1_R, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663 RPOLA_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00115 RNA_POL_II_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B8N404-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNVYFPYSK APLRTIKEIQ FGLFSPEEIK RMSVVHVEYP ETMDEQRQRP
60 70 80 90 100
RTKGLNDPRL GTIDRQWNCE TCEEGQKECP GHFGHIELAT PVFHIGFLTK
110 120 130 140 150
IKKLLETVCH NCGKIKANTS DSKFLEALRM RDPKRRFDHI WRLSKDITIC
160 170 180 190 200
EADPPPDEDE PYAKESSKPT RMHGGCGNAQ PTIRKEGITL VGTWKPSKSM
210 220 230 240 250
MDEMDMQQPE KKTITPQMAL NIFRNISHED VRIMGLSNDY ARPEWMVLTV
260 270 280 290 300
LPVPPPPVRP SVLVGGSTSG QRGEDDLTYK LAEIVRANQN VQRCEQEGAP
310 320 330 340 350
EHVVREFESL LQYHVATYMD NDIAGQPKAM QKSNRPVKAI RSRLKGKEGR
360 370 380 390 400
LRQNLMGKRV DFSARTVITG DPNLSLDEVG VPKSIARTLT YPEVVTPYNI
410 420 430 440 450
DKLQQLVSNG PNEHPGARYI VRDNGERIDL RHAKRAGGQQ LLYGWKVERH
460 470 480 490 500
VMDGDVILFN RQPSLHKESM MGHRVRVMPY STFRLNLSVT TPYNADFDGD
510 520 530 540 550
EMNLHVPQSE ESRAELLQLA LVPMNIVSPQ RNGPLMGIVQ DTLCGIYKIC
560 570 580 590 600
RRDTFLTKEQ VMNLMMWVPD WDGVIPPPAI LKPRPRWTGK QIISMALPSG
610 620 630 640 650
LNLLRVDKDN SALSEKFAPL NDGGLLIHGG QLMYGMFSKK TVGASGGGVI
660 670 680 690 700
HTIFNEYGPG TAVAFFNGAQ AIVNYWLLHN GFSIGIGDTI PDAVTIQRIE
710 720 730 740 750
NCVRERKKEV ETITASATDN TLEPLPGMNV RETFESKVSR ALNNARDEAG
760 770 780 790 800
SETEKSLKDL NNAIQMARSG SKGSTINISQ MTAVVGQQSV EGKRIPFGFK
810 820 830 840 850
YRTLPHFTKD DYSPESRGFV ENSYLRGLTP TEFFFHAMAG REGLIDTAVK
860 870 880 890 900
TAETGYIQRK LVKALEEVMV KYDGTVRNSL GDIIQFIYGE DGLDGAHIEN
910 920 930 940 950
QRVDIIKCSD DQFRDRFRID LMDPERSLGP EVLEQANEIA GDVEVQRYLD
960 970 980 990 1000
EEWEQLLKAR AFLRTVAKED EEMMQLPINV QRILEMARTT FRIREGTISD
1010 1020 1030 1040 1050
LHPAEVIPQV QALLDRLLIV RGDDPISQEA QENATLLFKA QLRSRLAFRR
1060 1070 1080 1090 1100
LVTEYSMNKL AFQHVIGAIE SRFAKANAPA GEMVGVLAAQ SIGEPATQMT
1110 1120 1130 1140 1150
LNTFHFAGVS SKNVTLGVPR LKEILNVATN IKTPSMTVYQ EPGRTHDKEG
1160 1170 1180 1190 1200
AKQLRSVVEH TSLRSVTEAT EIYYDPDIQS TVIENDRDMV ESYFIIPEDV
1210 1220 1230 1240 1250
TDDSSRQSKW LLRIILSRPK LLDKGLTVQD VATRIKQAYP KDIAVIFSDN
1260 1270 1280 1290 1300
NADEQVIRIR QIQDHKEDED DDDIEYDVTL KKLEQHLLDT LTLRGVNGVE
1310 1320 1330 1340 1350
RAFINEKSKV RVLEDGSLFT SKVDPLCKEW VLETSGSALG EVLAVPGVDA
1360 1370 1380 1390 1400
TRTYSNQFIE VFEVFGIEAA RTAVLRELTQ VLAFDGSYVN HRHLALLVDV
1410 1420 1430 1440 1450
MTVRGYLTPV TRHGINRADN GALMRCSFEE TVEILLEAAA FGELDDCRGV
1460 1470 1480 1490 1500
SENLILGQMA PAGTGEFDIY LDQNMLNTVV SNNARFGVMG AIGAKDAIIS
1510 1520 1530 1540 1550
DGASTQYDTG SPMQDNAYIG TPDPESNFSP IRQAGAESPG GFTEYQPTGG
1560 1570 1580 1590 1600
FGGGFSPAAT SPAGYSPSSP FSANPTSPGY SPSSSYSPTS PGMAMTSPRF
1610 1620 1630 1640 1650
SMTSPGFSPA SPSFAPTSPA YSPTSPAYGQ ASPTSPSYSP TSPGFSPTSP
1660 1670 1680 1690 1700
NYSPTSPSFS PASPAFSPTS PSYSPTSPAI GGAARHLSPT SPTSPKYTPT
1710 1720 1730 1740
SPGWSPTSPQ TYSPTSPNFA GSPTSPGGPT SPGYSPTSPA FSPS
Length:1,744
Mass (Da):192,664
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A85E5B71302B823
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EQ963473 Genomic DNA Translation: EED56055.1

NCBI Reference Sequences

More...
RefSeqi
XP_002374837.1, XM_002374796.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EED56055; EED56055; AFLA_033270

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7910175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afv:AFLA_033270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963473 Genomic DNA Translation: EED56055.1
RefSeqiXP_002374837.1, XM_002374796.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi5059.CADAFLAP00002702

Proteomic databases

PRIDEiB8N404

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED56055; EED56055; AFLA_033270
GeneIDi7910175
KEGGiafv:AFLA_033270

Organism-specific databases

EuPathDBiFungiDB:AFLA_033270

Phylogenomic databases

HOGENOMiHOG000222975
KOiK03006
OMAiEDGLCGE

Family and domain databases

Gene3Di1.10.132.30, 1 hit
3.30.1360.140, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR000684 RNA_pol_II_repeat_euk
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR007075 RNA_pol_Rpb1_6
IPR007073 RNA_pol_Rpb1_7
IPR038593 RNA_pol_Rpb1_7_sf
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
PF04992 RNA_pol_Rpb1_6, 1 hit
PF04990 RNA_pol_Rpb1_7, 1 hit
PF05001 RNA_pol_Rpb1_R, 12 hits
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
PROSITEiView protein in PROSITE
PS00115 RNA_POL_II_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB8N404_ASPFN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B8N404
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 16, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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