Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal peptidase complex catalytic subunit sec11

Gene

sec11

Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit sec11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:sec11
ORF Names:TSTA_031580
OrganismiTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
Taxonomic identifieri441959 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:TSTA_031580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini40 – 191LumenalSequence analysisAdd BLAST152

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123671 – 191Signal peptidase complex catalytic subunit sec11Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiB8M5K5

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Protein-protein interaction databases

STRINGi441959.XP_002480333.1

Structurei

3D structure databases

SMRiB8M5K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
InParanoidiB8M5K5
OMAiMMWKGLG
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit

Sequencei

Sequence statusi: Complete.

B8M5K5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSALGGNLS NARQSIAQVL NFALVLSTAF MLWKGVSIVS NSSSPIVVVL
60 70 80 90 100
SGSMEPAFQR GDLLFLWNRG ERAEVGEIVV YNVRGKDIPI VHRVVRSYTE
110 120 130 140 150
EDKKLKAKKT KAGLPYVAPQ KLLTKGDNNL ADDTELYARG QEFLDRKEDI
160 170 180 190
VGSVRGYIPG VGYVTIMLSE HPWLKTVLLG VMGLMVVFQR E
Length:191
Mass (Da):21,110
Last modified:March 3, 2009 - v1
Checksum:i32D23773221156C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA Translation: EED19899.1
RefSeqiXP_002480333.1, XM_002480288.1

Genome annotation databases

EnsemblFungiiEED19899; EED19899; TSTA_031580
GeneIDi8107769

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ962654 Genomic DNA Translation: EED19899.1
RefSeqiXP_002480333.1, XM_002480288.1

3D structure databases

SMRiB8M5K5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441959.XP_002480333.1

Protein family/group databases

MEROPSiS26.010

Proteomic databases

PRIDEiB8M5K5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED19899; EED19899; TSTA_031580
GeneIDi8107769

Organism-specific databases

EuPathDBiFungiDB:TSTA_031580

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
InParanoidiB8M5K5
OMAiMMWKGLG
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_TALSN
AccessioniPrimary (citable) accession number: B8M5K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again